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Detailed Phytochemical Composition, Cyto-/Hepatotoxicity, and Antioxidant/Anti-Inflammatory Profile of Moroccan Spices: A Study on Coriander, Caraway, and Mystical Cumin

2024Journal article Open access
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dc.contributor.authorBouzaid, Hiba
dc.contributor.authorEspírito Santo, Liliana
dc.contributor.authorFerreira, Diana M.
dc.contributor.authorMachado, Susana
dc.contributor.authorCosta, Anabela S.G.
dc.contributor.authorDias, Maria Inês
dc.contributor.authorCalhelha, Ricardo C.
dc.contributor.authorBarros, Lillian
dc.contributor.authorChater, Oumaima
dc.contributor.authorRodi, Youssef Kandri
dc.contributor.authorErrachidi, Faouzi
dc.contributor.authorChahdi, Fouad Ouazzani
dc.contributor.authorOliveira, Beatriz
dc.contributor.authorAlves, Rita C.
dc.date.accessioned2024-10-08T13:53:26Z
dc.date.available2024-10-08T13:53:26Z
dc.date.issued2024
dc.description.abstractCoriander, caraway, and mystical cumin are famous for their aromatic properties and widely used in Moroccan cuisine. The nutritional/phytochemical composition of their seeds (used for food flavoring and preservation) were compared. Their antioxidant, anti-inflammatory, cytotoxic and hepatotoxic effects were also explored. The fat content was similar among the samples (13%), with monounsaturated fatty acids being predominant. The coriander and mystical cumin seeds were extremely rich in C18:1n9c (81 and 85%, respectively) while, in the caraway, C18:1n12 (25%) was found together with C18:1n9c (32%). The caraway seeds also presented a higher proportion of C18:2n6c (34%) than the other seeds (13 and 8%, correspondingly). γ-Tocotrienol was the major vitamin E form in all the samples. The caraway seeds contained double the amount of protein (~18%) compared to the other seeds (~8%) but, qualitatively, the amino acid profiles among all seeds were similar. The seeds were also rich in dietary fiber (40–53%); however, differences were found in their fiber profiles. Caraway showed the highest antioxidant profile and anti-inflammatory activity and an LC-DAD-ESI/MSn analysis revealed great differences in the phenolic profiles of the samples. Cytotoxicity (NCI-H460, AGS, MCF-7, and CaCo2) and hepatotoxicity (RAW264.7) were not observed. In sum, besides their flavoring/preservation properties, these seeds are also relevant source of bioactive compounds with health-promoting activities.pt_PT
dc.description.sponsorshipThe authors acknowledge FCT/MCTES (Portugal) for the national funds received through the projects UIDB/50006/2020 (DOI 10.54499/UIDB/50006/2020), UIDP/50006/2020 (DOI 10.54499/UIDP/50006/2020), and LA/P/0008/2020 (DOI 10.54499/LA/P/0008/2020). The authors are also grateful for the financial support from the national funds FCT/MCTES to CIMO (UIDB/00690/2020 and UIDP/00690/2020) and SusTEC (LA/P/0007/2020); national funding by FCT, P.I., through the institutional scientific employment program contract for L. Barros, and M.I. Dias and R. Calhelha contracts. R. C. Alves (ref. CEECIND/01120/2017; DOI 10.54499/CEECIND/01120/ 2017/CP1427/CT0001) thanks the FCT for funding through the Scientific Employment Stimulus—Individual Call. L. Espírito Santo is grateful to LAQV—Tecnologias e Processos —UIDB/50006/2020 for her grant REQUIMTE 2023-49.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationBouzaid, Hiba; Espírito Santo, Liliana; Ferreira, Diana M.; Machado, Susana; Costa, Anabela S. G.; Dias, Maria Inês; Calhelha, Ricardo C.; Barros, Lillian; Chater, Oumaima; Rodi, Youssef Kandri; Errachidi, Faouzi; Chahdi, Fouad Ouazzani; Oliveira, Maria Beatriz P. P.; Alves, Rita C. (2024). Detailed Phytochemical Composition, Cyto-/Hepatotoxicity, and Antioxidant/Anti-Inflammatory Profile of Moroccan Spices: A Study on Coriander, Caraway, and Mystical Cumin. Molecules. ISSN 1420-3049. 29:15, p. 1-23pt_PT
dc.identifier.doi10.3390/molecules29153485pt_PT
dc.identifier.issn1420-3049
dc.identifier.urihttp://hdl.handle.net/10198/30376
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
dc.relationAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
dc.relationAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
dc.relationMountain Research Center
dc.relationMountain Research Center
dc.relationAssociate Laboratory for Sustainability and Tecnology in Mountain Regions
dc.relationNot Available
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectCarum carvi L.pt_PT
dc.subjectCoriandrum sativum L.pt_PT
dc.subjectAmmodaucus leucotrichus Cross. & Dur.pt_PT
dc.subjectNutritional profilept_PT
dc.subjectPhenolic screeningpt_PT
dc.subjectCell-based assayspt_PT
dc.titleDetailed Phytochemical Composition, Cyto-/Hepatotoxicity, and Antioxidant/Anti-Inflammatory Profile of Moroccan Spices: A Study on Coriander, Caraway, and Mystical Cuminpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
oaire.awardTitleAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
oaire.awardTitleAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
oaire.awardTitleMountain Research Center
oaire.awardTitleMountain Research Center
oaire.awardTitleAssociate Laboratory for Sustainability and Tecnology in Mountain Regions
oaire.awardTitleNot Available
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F50006%2F2020/PT
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oaire.awardURIinfo:eu-repo/grantAgreement/FCT/CEEC IND 2017/CEECIND%2F01120%2F2017%2FCP1427%2FCT0001/PT
oaire.citation.issue15pt_PT
oaire.citation.startPage3485pt_PT
oaire.citation.titleMoleculespt_PT
oaire.citation.volume29pt_PT
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oaire.fundingStreamCEEC IND 2017
person.familyNameDias
person.familyNameCalhelha
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person.givenNameMaria Inês
person.givenNameRicardo C.
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project.funder.identifierhttp://doi.org/10.13039/501100001871
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project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
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