Publication
Chiral separation of Ketoprofen enantiomers by preparative and simulated moving bed chromatography
| dc.contributor.author | Ribeiro, António E. | |
| dc.contributor.author | Gomes, Pedro Sá | |
| dc.contributor.author | Pais, Luís S. | |
| dc.contributor.author | Rodrigues, Alírio | |
| dc.date.accessioned | 2012-03-01T10:55:49Z | |
| dc.date.available | 2012-03-01T10:55:49Z | |
| dc.date.issued | 2011 | |
| dc.description.abstract | The pharmaceutical industry is now directed to the market of more safety and efficient drugs, based on single enantiomers. Ketoprofen, still used as a racemic pharmaceutical drug, belongs to the profens class, one of the most representative of the non-steroidal anti-inflammatory drugs. This work presents the chiral separation of ketoprofen enantiomers by simulated moving bed technology, using a laboratory scale unit (the FlexSMB-LSRE1) with six columns, packed with the Chiralpak AD1 stationary phase (20 lm). A comparative study between a mobile phase composed of a traditional high hydrocarbon content (10%ethanol=90%n-hexane=0- .01%TFA) and a strong polar organic composition (100%ethanol= 0.01%TFA) is presented. The study includes the measurement of the adsorption isotherms, elution, and frontal chromatography experiments, carried out on a SMB column for both compositions. The results obtained allowed the prediction and optimization of the SMB operation. Using pure ethanol as solvent and a racemic feed concentration of 40 g=L, purities above 98.6% on both outlet streams were obtained, with a productivity of 3.84 gfeed=(Lbed.hr) and a solvent consumption of 0.78Lsolvent=gfeed. The results obtained in the experimental separation of ketoprofen enantiomers by SMB chromatography indicates that pure ethanol presents better performances than the classic high hydrocarbon content composition. | por |
| dc.identifier.citation | Ribeiro, António E.; Gomes, Pedro Sá; Pais, Luís S.; Rodrigues, Alírio E. (2011): Chiral separation of ketoprofen enantiomers by preparative and simulated moving bed chromatography. Separation Science and Technology. ISSN 0149-6395. 46:11, p. 1726-1739 | por |
| dc.identifier.doi | 10.1080/01496395.2011.582070 | |
| dc.identifier.issn | 0149-6395 | |
| dc.identifier.uri | http://hdl.handle.net/10198/6674 | |
| dc.language.iso | eng | por |
| dc.peerreviewed | yes | por |
| dc.publisher | Taylor & Francis | por |
| dc.subject | Letoprofen | por |
| dc.subject | Preparative chiral separation | por |
| dc.subject | Simulated moving bed chromatography | por |
| dc.subject | Solvent composition | por |
| dc.title | Chiral separation of Ketoprofen enantiomers by preparative and simulated moving bed chromatography | por |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT/POCI/POCI%2FEQU%2F59738%2F2004/PT | |
| oaire.citation.endPage | 1739 | por |
| oaire.citation.startPage | 1726 | por |
| oaire.citation.title | Separation Science and Technology | por |
| oaire.fundingStream | POCI | |
| person.familyName | Ribeiro | |
| person.familyName | Pais | |
| person.givenName | António E. | |
| person.givenName | Luís S. | |
| person.identifier.ciencia-id | 3211-D5B0-870D | |
| person.identifier.ciencia-id | 421E-0CCD-A84F | |
| person.identifier.orcid | 0000-0003-4569-7887 | |
| person.identifier.orcid | 0000-0002-3000-2862 | |
| person.identifier.scopus-author-id | 23390701300 | |
| person.identifier.scopus-author-id | 6603930478 | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| rcaap.rights | restrictedAccess | por |
| rcaap.type | article | por |
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