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Advisor(s)
Abstract(s)
The pharmaceutical industry is now directed to the market of
more safety and efficient drugs, based on single enantiomers. Ketoprofen,
still used as a racemic pharmaceutical drug, belongs to the
profens class, one of the most representative of the non-steroidal
anti-inflammatory drugs. This work presents the chiral separation
of ketoprofen enantiomers by simulated moving bed technology,
using a laboratory scale unit (the FlexSMB-LSRE1) with six columns,
packed with the Chiralpak AD1 stationary phase (20 lm).
A comparative study between a mobile phase composed of a traditional
high hydrocarbon content (10%ethanol=90%n-hexane=0-
.01%TFA) and a strong polar organic composition (100%ethanol=
0.01%TFA) is presented. The study includes the measurement of
the adsorption isotherms, elution, and frontal chromatography
experiments, carried out on a SMB column for both compositions.
The results obtained allowed the prediction and optimization of
the SMB operation. Using pure ethanol as solvent and a racemic
feed concentration of 40 g=L, purities above 98.6% on both outlet
streams were obtained, with a productivity of 3.84 gfeed=(Lbed.hr)
and a solvent consumption of 0.78Lsolvent=gfeed. The results obtained
in the experimental separation of ketoprofen enantiomers by
SMB chromatography indicates that pure ethanol presents
better performances than the classic high hydrocarbon content
composition.
Description
Keywords
Letoprofen Preparative chiral separation Simulated moving bed chromatography Solvent composition
Citation
Ribeiro, António E.; Gomes, Pedro Sá; Pais, Luís S.; Rodrigues, Alírio E. (2011): Chiral separation of ketoprofen enantiomers by preparative and simulated moving bed chromatography. Separation Science and Technology. ISSN 0149-6395. 46:11, p. 1726-1739
Publisher
Taylor & Francis