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The health-benefits and phytochemical profile of Salvia apiana and Salvia farinacea var. Victoria blue decoctions

2019Journal article Open access
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dc.contributor.authorAfonso, Andrea Luísa Fernandes
dc.contributor.authorPereira, Olívia R.
dc.contributor.authorFernandes, Ângela
dc.contributor.authorCalhelha, Ricardo C.
dc.contributor.authorSilva, Artur
dc.contributor.authorFerreira, Isabel C.F.R.
dc.contributor.authorCardoso, Susana M.
dc.date.accessioned2019-07-30T11:17:46Z
dc.date.available2019-07-30T11:17:46Z
dc.date.issued2019
dc.description.abstractSalvia apiana and Salvia farinacea var. Victoria Blue decoctions were screened for diverse bioactivities, including the ability to counteract oxidative and inflammatory events, as well as to act as cytotoxic and antimicrobial agents. Both extracts showed good activities and that of S. apiana origin was particularly effective regarding the ability to prevent lipid peroxidation and to prevent nitric oxide (NO ) production in lipopolysaccharide (LPS)-activated murine macrophage RAW 264.7 cell line (EC50 = 50 µg/mL). Moreover, it displayed high cytotoxic capacity against hepatocellular carcinoma HepG2, cervical carcinoma HeLa, and breast carcinoma cells MCF-7, but comparatively low effects in porcine liver primary cells, which highlights its selectivity (GI50 = 41–60 µg/mL vs. 362 µg/mL, respectively). Further, it exhibited inhibitory and lethal potential against a panel of Gram-positive and Gram-negative bacteria. It is possible that the bioactive properties of the two Salvia extracts are associated to their phenolic components and, in the particular case of S. apiana, to its richness in phenolic terpenes, namely in rosmanol, hydroxycarnosic acid and a derivative of sageone, which were found in the extract.pt_PT
dc.description.sponsorshipFoundation for Science and Technology (FCT), the European Union, the National Strategic Reference Framework (QREN), the European Regional Development Fund (FEDER), and Operational Programme Competitiveness Factors (COMPETE), for funding the Organic Chemistry Research Unit (QOPNA) (FCT UID/QUI/00062/2019) and Mountain Research Center (CIMO) (UID/AGR/00690/2019), through national funds and where applicable co-financed by the FEDER, within the PT2020 Partnership Agreement. A. Fernandes and R. Calhelha thank the national funding by FCT, P.I., through the institutional scientific employment program-contract. Project AgroForWealth (CENTRO-01-0145-FEDER-000001), funded by Centro2020, through FEDER and PT2020, financed the research contract of Susana M. Cardoso.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationAfonso, Andrea F.; Pereira, Olívia R.; Fernandes, Ângela; Calhelha, Ricardo C.; Silva, Artur; Ferreira, Isabel C.F.R.; Cardoso, Susana M. (2019). The health-benefits and phytochemical profile of Salvia apiana and Salvia farinacea var. Victoria blue decoctions. Antioxidants. ISSN 2076-3921. 8:8, p. 1-14pt_PT
dc.identifier.doi10.3390/antiox8080241pt_PT
dc.identifier.issn2076-3921
dc.identifier.urihttp://hdl.handle.net/10198/19458
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationOrganic Chemistry, Natural Products and Food Stuffs
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectSagept_PT
dc.subjectBioactivitypt_PT
dc.subjectAntioxidantspt_PT
dc.subjectAnti-inflammatorypt_PT
dc.subjectCytotoxicitypt_PT
dc.subjectAntibacterialpt_PT
dc.subjectPhenolic compoundspt_PT
dc.subjectTerpenespt_PT
dc.titleThe health-benefits and phytochemical profile of Salvia apiana and Salvia farinacea var. Victoria blue decoctionspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleOrganic Chemistry, Natural Products and Food Stuffs
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FQUI%2F00062%2F2019/PT
oaire.citation.conferencePlaceBasel, Switzerlandpt_PT
oaire.citation.endPage14pt_PT
oaire.citation.issue8pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleAntioxidantspt_PT
oaire.citation.volume8pt_PT
oaire.fundingStream6817 - DCRRNI ID
person.familyNameAfonso
person.familyNamePereira
person.familyNameFernandes
person.familyNameCalhelha
person.familyNameFerreira
person.givenNameAndrea Luísa Fernandes
person.givenNameOlívia R.
person.givenNameÂngela
person.givenNameRicardo C.
person.givenNameIsabel C.F.R.
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person.identifier.ciencia-id2015-0434-AE7C
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person.identifier.ciencia-id9418-CF95-9919
person.identifier.orcid0000-0002-8858-1617
person.identifier.orcid0000-0002-6275-3134
person.identifier.orcid0000-0002-0157-9873
person.identifier.orcid0000-0002-6801-4578
person.identifier.orcid0000-0003-4910-4882
person.identifier.ridH-1049-2014
person.identifier.ridJ-2172-2014
person.identifier.ridE-8500-2013
person.identifier.scopus-author-id36766901000
person.identifier.scopus-author-id52264387000
person.identifier.scopus-author-id6507978333
person.identifier.scopus-author-id36868826600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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