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Study of the antioxidant, antimicrobial and anti-inflammatory activities of two Euphorbia species

2022Conference object Open access
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dc.contributor.authorPerez Vazquez, Ana
dc.contributor.authorAlvarez, Paula Barciela
dc.contributor.authorSilva, Tayse Ferreira
dc.contributor.authorRodrigues, Daniele Bobrowski
dc.contributor.authorMandim, Filipa
dc.contributor.authorPires, Tânia C.S.
dc.contributor.authorCarpena Rodríguez, María
dc.contributor.authorSimal-Gandara, Jesus
dc.contributor.authorBarros, Lillian
dc.contributor.authorPrieto Lage, Miguel A.
dc.date.accessioned2023-03-17T14:14:17Z
dc.date.available2023-03-17T14:14:17Z
dc.date.issued2022
dc.description.abstractIn this research, a study of the antioxidant, antimicrobial and anti-inflammatory activities of two Euphorbia species (Euphorbia hirta and Euphorbia jolkinii) was developed. Euphorbia species belong to the Euphorbiaceae family, being commonly found in America and tropical Africa. Euphorbia species have been traditionally used in folk medicine to treat gonorrhea, migraines, intestinal parasites, warts, and skin diseases [1]. Since there is more data available of Euphorbia hirta, the aim of this study was to provide a comparison between E. hirta and E. jokinii regarding their antioxidant, antimicrobial and anti-inflammatory activities. For the cellular antioxidant activity, murine macrophage cells RAW 264.7 were used following the procedure described by Wolf & Lui (2007). E. hirta showed better inhibition percentage results than E. jolkinii, being 2,000 μg/mL, the maximum concentration tested for both samples. Extracts of both Euphorbia species were used to determine their antimicrobial activity. Gram-negative and Gram-positive food and clinical bacteria were tested for this assay. Moreover, Streptomycin, Methicillin and Ampicillin were used as controllers to compare both MIC and MBC results. For the food bacteria, E. jolkinii had better MIC results than E. hirta when Gram-negative bacteria were tested, although it was lower than controllers. MBC results for both Euphorbia species were similar and lower than the controllers. When Gram-positive clinical bacteria were tested, similar MIC results between both extracts were obtained. However, when L. monocytogenes and S. aureus were tested, E. jolkinii showed better MIC results. Antifungal activity was also assessed using ketoconazole as control and Aspergillus brasiliensis and Aspergillus fumigatus as fungi. Unsatisfactory results were obtained for both Euphorbia species for both fungi. AGS, CaCo2, MCF-7, NCl-H460, PLP2 and RAW 264.7 cell lines were used for the anti-inflammatory assay. Ellipticine was used as control in all the cell lines except in RAW 264.7, where dexamethasone was used. Results showed lower anti-inflammatory activity of the 2 extracts compared to the controllers in all cell lines, being E. jolkinii the one with lower GI50. Considering the obtained results, although E. hirta has been widely studied, E. jolkinii showed better antimicrobial and anti-inflammatory activities, being a suitable option for the pharmacological industry.pt_PT
dc.description.sponsorshipThe research leading to these results was supported by MICINN supporting the Ramón y Cajal grant for M.A. Prieto (RYC-2017-22891); by Xunta de Galicia for supporting the program EXCELENCIAED431F 2020/12 and the pre-doctoral grant of M. Carpena (ED481A 2021/313). The authors are grateful to the Foundation for Science and Technology (FCT,Portugal) for financial support through national funds FCT/MCTES (PIDDAC) to CIMO (UIDB/00690/2020 and UIDP/00690/2020) and SusTEC (LA/P/0007/2021).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationPerez Vazquez, Ana; Alvarez, Paula Barciela; Silva, Tayse Ferreira; Rodrigues, Daniele B.; Mandim, Filipa; Pires, Tânia C.S.; Carpena Rodríguez, María; Simal-Gandara, Jesus; Barros, Lillian; Prieto Lage, Miguel A. (2022). Study of the antioxidant, antimicrobial and anti-inflammatory activities of two Euphorbia species. In XXVI Encontro Galego-Portugues de Química: Book of Abstracts. Santiago de Compostelapt_PT
dc.identifier.isbn978-84-09-45895-0
dc.identifier.urihttp://hdl.handle.net/10198/27812
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherUniversidade de Santiago de Compostelapt_PT
dc.relationLA/P/0007/2021pt_PT
dc.relationMountain Research Center
dc.relationMountain Research Center
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectEuphorbiapt_PT
dc.subjectResearch Subject Categories::MEDICINE::Morphology, cell biology, pathologypt_PT
dc.titleStudy of the antioxidant, antimicrobial and anti-inflammatory activities of two Euphorbia speciespt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.awardTitleMountain Research Center
oaire.awardTitleMountain Research Center
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00690%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F00690%2F2020/PT
oaire.citation.conferencePlaceSantiago de Compostelapt_PT
oaire.citation.endPage354pt_PT
oaire.citation.startPage354pt_PT
oaire.citation.titleXXVI Encontro Galego-Portugues de Química: Book of Abstractspt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
person.familyNameRodrigues
person.familyNameMandim
person.familyNamePires
person.familyNameBarros
person.familyNamePrieto Lage
person.givenNameDaniele Bobrowski
person.givenNameFilipa
person.givenNameTânia C.S.P.
person.givenNameLillian
person.givenNameMiguel A.
person.identifier2118829
person.identifier469085
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person.identifier.ciencia-id9616-35CB-D001
person.identifier.ciencia-id221E-1E00-AB74
person.identifier.orcid0000-0003-0260-5751
person.identifier.orcid0000-0002-6494-2326
person.identifier.orcid0000-0002-3954-3833
person.identifier.orcid0000-0002-9050-5189
person.identifier.orcid0000-0002-3513-0054
person.identifier.ridQ-2842-2018
person.identifier.ridJ-3600-2013
person.identifier.ridG-4516-2011
person.identifier.scopus-author-id57057440000
person.identifier.scopus-author-id35236343600
person.identifier.scopus-author-id35937495700
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typeconferenceObjectpt_PT
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