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Microscale flow dynamics of red blood cells in microchannels: an experimental and numerical analysis

2011Conference object Open access
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dc.contributor.authorLima, Rui A.
dc.contributor.authorFernandes, Carla S.
dc.contributor.authorDias, Ricardo P.
dc.contributor.authorIshikawa, Takuji
dc.contributor.authorImai, Yohsuke
dc.contributor.authorYamaguchi, Takami
dc.date.accessioned2014-09-04T14:46:49Z
dc.date.available2014-09-04T14:46:49Z
dc.date.issued2011
dc.description.abstractThe blood flow dynamics in microcirculation depends strongly on the microvascular networks composed with short irregular vessel segments which are linked by numerous bifurcations. This paper presents the application of a confocal micro-PTV system to track RBCs through a rectangular polydimethysiloxane (PDMS) microchannel with a bifurcation. By using a confocal micro-PTV system, we have measured the effect of bifurcation on the flow behaviour of both fluorescent particles diluted in pure water and RBCs in concentrated suspensions. After performing simulations with the commercial finite element software package POLYFLOW, some experimental results were compared with the numerical results and the limitations of these simulations were outlined.por
dc.description.sponsorshipThis study was supported in part by the following grants: Grant-in-Aid for Science and Technology (BII/UNI/0532/EME/2008, PTDC/SAU-BEB/108728/2008, PTDC/SAUBEB/ 105650/2008 and PTDC/EME-MFE/099109/2008) from the Science and Technology Foundation (FCT) and COMPETE, Portugal and Grant-in-Aid for Scientific Research (S) from the Japan Society for the Promotion of Science (JSPS; No.19100008). We also acknowledge the support from the 2007 Global COE Program “Global Nano-Biomedical Engineering Education and Research Network”. The authors would like also to thank Dr. C. Balsa for his valuable assistance and support for the MATLAB numerical calculations and Ms. B. Oliveira, Ms. D. Cidre and Mr. M. Lagoela for their valuable technical assistance in this research work.
dc.identifier.citationLima, R.; Fernandes, Carla S.; Dias, Ricardo P.; Ishikawa, T.; Imai, Y.; Yamaguchi, T. (2011). Microscale flow dynamics of red blood cells in microchannels: an experimental and numerical analysis. In 2nd ECCOMAS Thematic Conference on Computational Vision andMedical Image processing, VIPimage 2009. Dordrecht: Springer. p. 297-309. ISBN 978-94-007-0010-9por
dc.identifier.isbn978-94-007-0010-9
dc.identifier.urihttp://hdl.handle.net/10198/10314
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherSpringerpor
dc.relationHemo-Networks - Experimental and computational investigations of the factors influencing blood flow in microvascular networks.
dc.relationANEURYSM - Hemodynamic Study in Cerebral Aneurysms
dc.subjectBlood flowpor
dc.subjectBifurcationpor
dc.subjectMicrochannelpor
dc.subjectMicrovascular networkspor
dc.titleMicroscale flow dynamics of red blood cells in microchannels: an experimental and numerical analysispor
dc.typeconference object
dspace.entity.typePublication
oaire.awardTitleHemo-Networks - Experimental and computational investigations of the factors influencing blood flow in microvascular networks.
oaire.awardTitleANEURYSM - Hemodynamic Study in Cerebral Aneurysms
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876-PPCDTI/PTDC%2FSAU-BEB%2F108728%2F2008/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876-PPCDTI/PTDC%2FSAU-BEB%2F105650%2F2008/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876-PPCDTI/PTDC%2FEME-MFE%2F099109%2F2008/PT
oaire.citation.endPage309por
oaire.citation.startPage297por
oaire.citation.titleComputational Vision and Medical Image Processingpor
oaire.citation.volume19por
oaire.fundingStream5876-PPCDTI
oaire.fundingStream5876-PPCDTI
oaire.fundingStream5876-PPCDTI
person.familyNameLima
person.familyNameFernandes
person.familyNameDias
person.givenNameRui A.
person.givenNameCarla S.
person.givenNameRicardo P.
person.identifier.ciencia-idEE12-C3FB-349D
person.identifier.ciencia-idF319-3D67-9DB7
person.identifier.orcid0000-0003-3428-637X
person.identifier.orcid0000-0002-3138-7493
person.identifier.orcid0000-0003-1503-998X
person.identifier.ridH-5157-2016
person.identifier.ridA-4269-2015
person.identifier.scopus-author-id18437397800
person.identifier.scopus-author-id8253740700
person.identifier.scopus-author-id7102885151
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspor
rcaap.typeconferenceObjectpor
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