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Palladium-catalyzed cyclisation-deprotection of o-halodiarylacetamides, obtained by C-N copper assisted coupling, to the corresponding 6H-Thieno-[2,3-c]carbazole

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With the aim of obtaining potential anti-tumoural thienocarbazoles by a ring B convergent method of synthesis, o-halodiarylacetamides were prepared by copper assisted C-N coupling' from 2-bromo-iodobenzene and 6-acetamido-2,3,5-trimethylbenzolb]thiophene, prepared from the 6-acetyl compound.

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Ferreira, Isabel C.F.R.; Queiroz, Maria-João R.P.; Kirsch, Gilbert (2001). Palladium-catalyzed Cyclisation-deprotection of o-halodiarylacetamides, obtained by C-N copper assisted coupling, to the corresponding 6H-Thieno-[2,3-c]carbazole. In 12th European Symposium on Organic Chemistry. Groningen

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