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Biomonitoring of polycyclic aromatic hydrocarbons exposure and short-time health effects in wildland firefighters during real-life fire events

2024Journal article Open access
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dc.contributor.authorPaiva, Ana Margarida
dc.contributor.authorBarros, Bela
dc.contributor.authorOliveira, Marta
dc.contributor.authorAlves, Sara Elisa Brás
dc.contributor.authorEsteves, Filipa
dc.contributor.authorFernandes, Adília
dc.contributor.authorVaz, Josiana A.
dc.contributor.authorSlezakova, Klara
dc.contributor.authorTeixeira, João Paulo Fernandes
dc.contributor.authorCosta, Solange
dc.contributor.authorMorais, Simone
dc.date.accessioned2024-06-11T16:15:20Z
dc.date.available2024-06-11T16:15:20Z
dc.date.issued2024
dc.description.abstractHuman biomonitoring data retrieved from real -life wildland firefighting in Europe and, also, worldwide are scarce. Thus, in this study, 176 Portuguese firefighters were biomonitored pre- and post- unsimulated wildfire combating (average:12-13 h; maximum: 55 h) to evaluate the impact on the levels of urinary polycyclic aromatic hydrocarbons hydroxylated metabolites (OHPAH; quantified by high-performance liquid chromatography with fluorescence detection) and the associated short-term health effects (symptoms, and total and differentiated white blood cells). Correlations between these variables and data retrieved from the self -reported questionnaires were also investigated. Firefighters were organized into four groups according to their exposure to wildfire emissions and their smoking habits: non-smoking non -exposed (NSNExp), non-smoking exposed (NSExp), smoking non -exposed (SNExp), and smoking and exposed (SExp). The most abundant metabolites were 1-hydroxynaphthalene and 1-hydroxyacenaphthene (1OHNaph + 1OHAce) (98-99 %), followed by 2-hydroxyfluorene (2OHFlu) (0.2-1.1 %), 1-hydroxyphenanthrene (1OHPhen) (0.2-0.4 %), and 1-hydroxypyrene (1OHPy) (0.1-0.2 %); urinary 3-hydroxybenzo(a)pyrene was not detected. The exposure to wildfire emissions significantly elevated the median concentrations of each individual and total OHPAH compounds in all groups, but this effect was more pronounced in non-smoking (1.7-4.2 times; p < 0.006) than in smoking firefighters (1.3-1.6 times; p < 0.03). The greatest discriminant of exposure to wildfire emissions was 1OHNaph + 1OHAce (increase of 4.2 times), while for tobacco smoke it was 2OHFlu (increase of 10 times). Post -exposure, white blood cells count significantly increased ranging from 1.4 (smokers, p = 0.025) to 3.7 -fold (non-smokers, p < 0.001), which was accompanied by stronger significant correlations (0.480 < r < 0.882; p < 0.04) between individual and total OHPAH and total white blood cells (and lymphocytes > monocytes > neutrophils in non-smokers), evidencing the impact of PAH released from wildfire on immune cells. This study identifies Portuguese firefighters with high levels of biomarkers of exposure to PAH and points out the importance of adopting biomonitoring schemes, that include multiple biomarkers of exposure and biomarkers of effect, and implementing mitigations strategies.pt_PT
dc.description.sponsorshipThis work was financially supported by the project PCIF/SSO/0017/2018 (doi:10.54499/PCIF/SSO/0017/2018) by the Fundacao para a Ciencia e a Tecnologia (FCT), Ministerio da Ciencia, Tecnologia e Ensino Superior (MCTES) through national funds.r Acknowledgment This work received support by UIDB/50006/2020 (DOI:10.544 99/UIDB/50006/2020) , UIDP/50006/2020 (DOI:10.54499/UIDP/5 0006/2020) , LA/P/0008/2020 (DOI:10.54499/LA/P/0008/2020) and through the project PCIF/SSO/0090/2019 (doi:10.54499/PCIF/SSO/0090/2019) by the Fundacao para a Ciencia e a Tecnologia (FCT) , Ministerio da Ciencia, Tecnologia e Ensino Superior (MCTES) through national funds. The authors would also like to thank to FCT and Euro-pean Union through Fundo Social Europeu (FSE) which supported the scientific contract CEEC-Individual 2017 Program Contract CEECIND/03666/2017 (DOI:10.54499/CEECIND/03666/2017/CP1427/CT0007) and the PhD grant 2020.07394.BD, respectively.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationPaiva, Ana Margarida; Barros, Bela; Oliveira, Marta; Alves, Sara; Esteves, Filipa; Fernandes, Adília; Vaz, Josiana A.; Slezáková, Klára; Teixeira, João Paulo; Costa, Solange; Morais, Simone (2024). Biomonitoring of polycyclic aromatic hydrocarbons exposure and short-time health effects in wildland firefighters during real-life fire events. Science of The Total Environment. ISSN 0048-9697. 926, p. 1-14pt_PT
dc.identifier.doi10.1016/j.scitotenv.2024.171801pt_PT
dc.identifier.eissn1879-1026
dc.identifier.issn0048-9697
dc.identifier.urihttp://hdl.handle.net/10198/29883
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
dc.relationAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
dc.relationAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
dc.relationFirefighting occupational exposure and early effects on the health of operational forces
dc.relationNot Available
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectOccupational exposurept_PT
dc.subjectHuman biomonitoringpt_PT
dc.subjectWildfire emissionspt_PT
dc.subjectPAHpt_PT
dc.titleBiomonitoring of polycyclic aromatic hydrocarbons exposure and short-time health effects in wildland firefighters during real-life fire eventspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
oaire.awardTitleAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
oaire.awardTitleAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
oaire.awardTitleFirefighting occupational exposure and early effects on the health of operational forces
oaire.awardTitleNot Available
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PCIF%2FSSO%2F0017%2F2018/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F50006%2F2020/PT
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oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0008%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PCIF%2FSSO%2F0090%2F2019/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/CEEC IND 2017/CEECIND%2F03666%2F2017%2FCP1427%2FCT0007/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POR_NORTE/2020.07394.BD/PT
oaire.citation.endPage14pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleScience of The Total Environmentpt_PT
oaire.citation.volume926pt_PT
oaire.fundingStream3599-PPCDT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream3599-PPCDT
oaire.fundingStreamCEEC IND 2017
oaire.fundingStreamPOR_NORTE
person.familyNameFernandes
person.familyNameVaz
person.givenNameAdília
person.givenNameJosiana A.
person.identifier.ciencia-id0514-76CD-8CCF
person.identifier.ciencia-id171B-88BA-64F5
person.identifier.orcid0000-0003-1658-4509
person.identifier.orcid0000-0002-6989-1169
person.identifier.ridV-8399-2017
person.identifier.scopus-author-id56489572200
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project.funder.identifierhttp://doi.org/10.13039/501100001871
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project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
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project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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