Publication
Separation of nadolol racemates by high pH reversed-phase simulated moving bed chromatography
| dc.contributor.author | Arafah, Rami | |
| dc.contributor.author | Ribeiro, António E. | |
| dc.contributor.author | Rodrigues, Alírio | |
| dc.contributor.author | Pais, Luís S. | |
| dc.date.accessioned | 2020-06-15T15:34:58Z | |
| dc.date.available | 2020-06-15T15:34:58Z | |
| dc.date.issued | 2018 | |
| dc.description.abstract | Nadolol is a pharmaceutical drug marketed as a mixture of four stereoisomers, used to treat cardiovascular diseases. This drug is a mixture of two pairs of racemates, therefore, its complete separation represents a challenging task. Recently, our research group reported the pseudo-binary separation of nadolol by SMB chromatography using both coated Chiralpak AD and Chiralpak IA immobilized chiral stationary phases. In this work, we present an alternative strategy, implementing a first achiral separation step, by using C18 columns to perform the separation of the two pairs of nadolol racemates under reversed-phase mode. Extensive experimental and simulation results will be presented including solvent screening, measurement of equilibrium and kinetic data, and both fixed-bed and SMB preparative separations. Extensive experimental and simulation results will be presented, including solvent screening, measurement of equilibrium adsorption isotherms, breakthrough measurements, and SMB (FlexSMB-LSRE unit) experimental preparative separation using C18 columns. | pt_PT |
| dc.description.sponsorship | This work is a result of project AIProcMat@N2020 - Advanced Industrial Processes and Materials for a Sustainable Northern Region of Portugal 2020”, with the reference NORTE-01-0145-FEDER-000006, supported by Norte Portugal Regional Operational Programme (NORTE 2020), under the Portugal 2020 Partnership Agreement, through the European Regional Development Fund (ERDF), and of project POCI-01-0145-FEDER-006984 – Associate Laboratory LSRE-LCM funded by ERDF through COMPETE2020 - Programa Operacional Competitividade e Internacionalização (POCI) – and by national funds through FCT - Fundação para a Ciência e a Tecnologia | pt_PT |
| dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
| dc.identifier.citation | Arafah, Rami; Ribeiro, António E.; Rodrigues, A.E.; Pais, L.S. (2018). Separation of nadolol racemates by high pH reversed-phase simulated moving bed chromatography. In 13th International Chemical and Biological Engineering Conference. Aveiro. ISBN 978-972-789-566-3 | pt_PT |
| dc.identifier.isbn | 978-972-789-566-3 | |
| dc.identifier.uri | http://hdl.handle.net/10198/22055 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.publisher | Universidade de Aveiro | pt_PT |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc/4.0/ | pt_PT |
| dc.subject | Nadolol racemates | pt_PT |
| dc.title | Separation of nadolol racemates by high pH reversed-phase simulated moving bed chromatography | pt_PT |
| dc.type | conference object | |
| dspace.entity.type | Publication | |
| oaire.citation.conferencePlace | Aveiro, Portugal | pt_PT |
| oaire.citation.title | 13th INTERNATIONAL CHEMICAL AND BIOLOGICAL ENGINEERING CONFERENCE | pt_PT |
| person.familyName | Arafah | |
| person.familyName | Ribeiro | |
| person.familyName | Pais | |
| person.givenName | Rami | |
| person.givenName | António E. | |
| person.givenName | Luís S. | |
| person.identifier.ciencia-id | AB16-ECBF-B886 | |
| person.identifier.ciencia-id | 3211-D5B0-870D | |
| person.identifier.ciencia-id | 421E-0CCD-A84F | |
| person.identifier.orcid | 0000-0002-7743-4988 | |
| person.identifier.orcid | 0000-0003-4569-7887 | |
| person.identifier.orcid | 0000-0002-3000-2862 | |
| person.identifier.scopus-author-id | 57151342900 | |
| person.identifier.scopus-author-id | 23390701300 | |
| person.identifier.scopus-author-id | 6603930478 | |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | conferenceObject | pt_PT |
| relation.isAuthorOfPublication | 3cd4864a-8aa6-46a2-9415-767a7551ee62 | |
| relation.isAuthorOfPublication | 52666376-f100-4407-87ef-dc5df3613761 | |
| relation.isAuthorOfPublication | c6d25534-8487-45b1-90af-d350f4e3ac55 | |
| relation.isAuthorOfPublication.latestForDiscovery | c6d25534-8487-45b1-90af-d350f4e3ac55 |
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