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Advisor(s)
Abstract(s)
Nadolol is a pharmaceutical drug marketed as a mixture of four
stereoisomers, used to treat cardiovascular diseases. This drug is a
mixture of two pairs of racemates, therefore, its complete separation
represents a challenging task. Recently, our research group reported
the pseudo-binary separation of nadolol by SMB chromatography
using both coated Chiralpak AD and Chiralpak IA immobilized
chiral stationary phases. In this work, we present an alternative
strategy, implementing a first achiral separation step, by using C18
columns to perform the separation of the two pairs of nadolol
racemates under reversed-phase mode. Extensive experimental and
simulation results will be presented including solvent screening,
measurement of equilibrium and kinetic data, and both fixed-bed and
SMB preparative separations. Extensive experimental and simulation
results will be presented, including solvent screening, measurement
of equilibrium adsorption isotherms, breakthrough measurements,
and SMB (FlexSMB-LSRE unit) experimental preparative separation
using C18 columns.
Description
Keywords
Nadolol racemates
Citation
Arafah, Rami; Ribeiro, António E.; Rodrigues, A.E.; Pais, L.S. (2018). Separation of nadolol racemates by high pH reversed-phase simulated moving bed chromatography. In 13th International Chemical and Biological Engineering Conference. Aveiro. ISBN 978-972-789-566-3
Publisher
Universidade de Aveiro