Repository logo
 
Publication

In vitro dissolution study in predicting oral absorption of drugs containing paracetamol using an electronic tongue

2014Conference object Open access
Simple item page
dc.contributor.authorPinto, Isabel C.
dc.contributor.authorDias, L.G.
dc.contributor.authorSantos, Ana M.
dc.contributor.authorFerraz, Liliana S.
dc.date.accessioned2018-03-21T14:48:33Z
dc.date.available2018-03-21T14:48:33Z
dc.date.issued2014
dc.description.abstractThe bioavailability of drugs is essential for the therapeutic efficacy of medicines, and it is therefore essential to conduct dissolution studies of drugs. The electronic tongue has been demonstrating potential usefulness in this area. Objectives: Verify the potential of electronic tongue in the analysis of paracetamol in different drugs; verify the ability to cross-sensitivity sensors in dissolution studies; selecting a lipidic polymer membrane electrode with good performance in monitoring of samples dissolution. Methods: Four samples of medicines containing 500mg of Paracetamol: unbranded uncoated pill, branded uncoated pill, unbranded coated pill and branded coated pill have been used. We used a dissolution medium simulating the gastric fasting conditions. The polymer membranes were formed by mixing: 4 lipidic additives, 5 plasticizers and polymer polyvinyl chloride. After stabilization of the potential signals from all electrodes, each sample was placed in a metal tube in contact with the dissolution medium. The experiment ended when the tablet was fully dissolved. The assays were repeated three times for each sample. Results: Yielded consistent dissolution profiles between repetitions of the same sample for some 40 tested sensors, including the 34 sensor which showed a similar behavior for both formulations. The uncoated pills obtained a dissolution profile of quick release (30ā€™-unbranded; 25ā€™-branded). The lengthy dissolutions resulted in different dissolution profiles between repetitions of the same sample of coated pills and capsules. Conclusions: The dissolution profile of drugs containing acetaminophen was followed through 40 potentiometric sensors having cross-sensitivity is selected sensor 34, which allow obtaining reproducible results.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationPinto, Isabel C.; Dias, LuĆ­s G.; Santos, Ana M.; Ferraz, Liliana S. (2014). In vitro dissolution study in predicting oral absorption of drugs containing paracetamol using an electronic tongue. In 2nd World Congress of Health Research. AtenciĆ³n Primaria. ISSN 0212-6567, 46 (Espec Cong 1), p. 86-86pt_PT
dc.identifier.issn0212-6567
dc.identifier.urihttp://hdl.handle.net/10198/16450
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relation.publisherversionhttps://www.journals.elsevier.com/atencion-primariapt_PT
dc.subjectDrug dissolutionpt_PT
dc.subjectElectronic tonguept_PT
dc.subjectParacetamolpt_PT
dc.titleIn vitro dissolution study in predicting oral absorption of drugs containing paracetamol using an electronic tonguept_PT
dc.typeconference object
dspace.entity.typePublication
oaire.citation.conferencePlaceViseu, Portugalpt_PT
oaire.citation.endPage86pt_PT
oaire.citation.issueEspec Cong 1pt_PT
oaire.citation.startPage86pt_PT
oaire.citation.title2nd World Congress of Health Researchpt_PT
oaire.citation.volume46pt_PT
person.familyNamePinto
person.familyNameDias
person.givenNameIsabel C.
person.givenNameLuĆ­s G.
person.identifier.ciencia-id851B-247F-C650
person.identifier.ciencia-id2F11-9092-FAAF
person.identifier.orcid0000-0003-4745-6489
person.identifier.orcid0000-0002-1210-4259
person.identifier.scopus-author-id23569169900
rcaap.rightsopenAccesspt_PT
rcaap.typeconferenceObjectpt_PT
relation.isAuthorOfPublication751d74ab-e27c-4713-97ba-62cad38d1890
relation.isAuthorOfPublicationeac8c166-4056-4ed0-8d8d-7ecb2c4481a5
relation.isAuthorOfPublication.latestForDiscoveryeac8c166-4056-4ed0-8d8d-7ecb2c4481a5

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
AtenciĆ³n Primaria_In vitro dissolution study in predicting oral absorption of paracetamol using an electronic tongue.pdf
Size:
202.03 KB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.75 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

ESSa - Resumos em Proceedings NĆ£o Indexados Ć  WoS/Scopus