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Advisor(s)
Abstract(s)
2-Styrylchromones constitute a small group of natural heterocyclic compounds with
significant biological properties. Certain natural and synthetic hydroxyl derivatives
have shown important pharmacological and mainly antioxidant activities [1 ,2].
We are interested in the design of new 2-styrylchromones analogues containing
hydroxyl groups at C-3 and in the Ca=C~ systems because they could increase the
antioxidation activity of these type of compounds [2]. Our first approach is the
preparation of epoxy systems and then we will try to open the epoxy ring to give the
desired hydroxyl derivatives. We studied the epoxidation of 2-styryl-chromones 1
with hydrogen peroxide and iodosylbenzene using [salen Mn(lll)] as catalyst, and
the epoxy products 2 were obtained in moderate yields. Since the best results were
obtained with iodosylbenzene, we applied oxidant to compounds 3 in order to prepare
4. In this communication, we will report the synthetic details and the structural
characterisation of the epoxides 3 and 4.
Description
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Citation
Santos, Clementina M.M.; Silva, Artur; Cavaleiro, José; Patonay, Támas; Levaí, Albert (2004). Epoxidation of 2-Styrylchromone Derivatives. In XXIst European Colloquim on Heterocyclic Chemistry. Sopron