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Differential Effects of Low and High Caffeine Doses on Bench Press Muscular Endurance: A Randomized, Double-Blind, Placebo-Controlled Crossover Study

datacite.subject.fosCiências Médicas::Ciências da Saúde
datacite.subject.sdg03:Saúde de Qualidade
datacite.subject.sdg12:Produção e Consumo Sustentáveis
dc.contributor.authorSaborosa, Guilherme Pereira
dc.contributor.authorLeite, Luciano Bernardes
dc.contributor.authorForte, Pedro
dc.contributor.authorMalheiro, Alexandra
dc.contributor.authorAfonso, Pedro Miguel Vaz
dc.contributor.authorArruda, Dan Holz
dc.contributor.authorCosta, Sebastião Felipe Ferreira
dc.contributor.authorSouza, Helton de Sá
dc.contributor.authorSilva, Sandro Fernandes
dc.date.accessioned2026-03-20T10:45:58Z
dc.date.available2026-03-20T10:45:58Z
dc.date.issued2026
dc.description.abstractCaffeine contributes to improvements in physical performance by enhancing muscular strength and endurance. However, it is necessary to evaluate the effects of different dosages on resistance training (RT) performance. Therefore, this study aimed to compare the effects of different caffeine doses (i.e., 3 mg·kg−1 and 6 mg·kg−1) on the maximum number of repetitions in a muscular endurance test. The study included 11 male participants (25.7 ± 5.9 years) who completed six in-person visits. During the first visit, a 24 h dietary recall (24HDR) was administered, anthropometric measurements were assessed, and one-repetition maximum (1RM) was determined in the flat bench press (BP). The second visit (baseline; BL) included a new 24HDR, assessment of muscle thickness using portable ultrasound (pre- and post-test), and a muscular endurance test in the BP at 80% of 1RM performed until concentric failure. The four subsequent visits followed the same protocol, with the administration of caffeine or placebo capsules 60 min before testing in a randomized, double-blind manner: low-dose caffeine (3 mg·kg−1; LC), high-dose caffeine (6 mg·kg−1; HC), low-dose placebo (3 mg·kg−1; LP), and high-dose placebo (6 mg·kg−1; HP). The first three interventions were conducted with 48 h intervals, and the remaining interventions were separated by a 7-day interval. The number of repetitions and total workload (TWL) increased in all conditions compared with baseline; however, no significant differences were observed (p > 0.05). LC and HP achieved the highest repetition values (LC: 12.09 ± 3.33 reps; HP: 12.27 ± 2.72 reps). Muscle thickness was greater in all conditions in the post-test assessment, showing a significant increase (p < 0.05). Low- or high-dose caffeine supplementation appears to moderately influence responses in a muscular endurance test, suggesting that caffeine may be a potential supplement for resistance training.eng
dc.description.sponsorshipThe authors would like to thank all the volunteers who generously participated in this study for their time, commitment, and effort. Their cooperation and dedication were essential for the successful completion of the experimental procedures and data collection.
dc.identifier.citationSaborosa, Guilherme Pereira; Leite, Luciano Bernardes; Forte, Pedro; Malheiro, Alexandra; Afonso, Pedro Miguel Vaz; Arruda, Dan Holz; Costa, Sebastião Felipe Ferreira; Souza, Helton de Sá; Silva, Sandro Fernandes (2026). Differential Effects of Low and High Caffeine Doses on Bench Press Muscular Endurance: A Randomized, Double-Blind, Placebo-Controlled Crossover Study. Applied Sciences. ISSN 2076-3417. 16:4, p. 1-13
dc.identifier.doi10.3390/app16041679
dc.identifier.issn2076-3417
dc.identifier.urihttp://hdl.handle.net/10198/36157
dc.language.isoeng
dc.peerreviewedyes
dc.publisherMDPI
dc.relation.ispartofApplied Sciences
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/
dc.subjectCaffeine supplementation
dc.subjectMuscular endurance
dc.subjectResistance training
dc.titleDifferential Effects of Low and High Caffeine Doses on Bench Press Muscular Endurance: A Randomized, Double-Blind, Placebo-Controlled Crossover Study
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage13
oaire.citation.issue4
oaire.citation.startPage1
oaire.citation.titleApplied Sciences
oaire.citation.volume16
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameForte
person.familyNameAfonso
person.givenNamePedro
person.givenNamePedro Miguel Vaz
person.identifier.ciencia-id351B-B16B-79C7
person.identifier.orcid0000-0003-0184-6780
person.identifier.orcid0009-0000-1077-7233
relation.isAuthorOfPublication3ecc6d1b-07a4-40d7-81f4-df6fd7b3d5b0
relation.isAuthorOfPublicatione60b84bd-26de-4b14-ba2d-4216d9088036
relation.isAuthorOfPublication.latestForDiscovery3ecc6d1b-07a4-40d7-81f4-df6fd7b3d5b0

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