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Garcínía brasiliensis leaves: Bioactive properties and phytochemical assessment

2018Conference object Open access
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dc.contributor.authorZan, Renato André
dc.contributor.authorFernandes, Ângela
dc.contributor.authorJedoz, Stephanie
dc.contributor.authorTaofiq, Oludemi
dc.contributor.authorCalhelha, Ricardo C.
dc.contributor.authorPires, Tânia C.S.P.
dc.contributor.authorMartins, Roberto Carlos Campos
dc.contributor.authorBarros, Lillian
dc.contributor.authorFerreira, Isabel C.F.R.
dc.date.accessioned2019-01-07T17:25:40Z
dc.date.available2019-01-07T17:25:40Z
dc.date.issued2018
dc.description.abstractThe Amazon rainforest is the home to several medicinal plant species popularly used for the treatment of a wide range of diseases. Despite the rich biodiversity of this region, there is still a lack of comprehensive studies regarding the uses, bioactivities, chemical composition and pharmacological properties of many of these medicinal plants [l]. In the present work, Garcinia brasiliensis Mart., a green plant native to the Amazon region, cultivated for its edible fruit, popularly referred to as "bacuparianão" or "guapomo" was studied. Some of its well reported bioactive properties include antioxidant, antidiabetic, anti-inflammatory, antispasmodic and antiprotozoal activities but very little studies have been conducted describing the phytochemical profile and establishing compounds-bioactivity relationships of the extracts obtained from its vegetative organs [2]. In view of these pharmaceutical potentials, leaves of G. brasilienses were collected at São Cristóvão site, Paraná, Brazil. They were then submitted to a cold methanol extraction, and further liquid-liquid partitioned to obtain hexane, dichloromethane and ethyl acetate fractions. The antioxidant, antiinflammatory, antimicrobial and cytotoxic activities of each fraction were tested, and the most bioactive fraction was submitted to phenolic characterization using HPLCDAD- ESI/MSn. The results showed that the ethyl acetate fraction showed the highest antioxidant activity which was comparable to Trolox, the positive control. This fraction also showed a broad spectrum antimicrobial activity against Gram-positive and Gramnegative bactéria, and Cândida albicans. The phenolic profile of the ethyl acetate fraction presented twelve flavonoids, being morelloflavone-7"-0-glucoside (52. 1±0.4 mg/g) and gardinia biflavonoid 2a glucoside (27. 5±0.2mg/g) the major compounds identified. These results indicate that leaves of G. brasiliensis might be a potential source of natural biomolecules for pharmaceutical and medicinal applications.pt_PT
dc.description.sponsorshipThe authors are grateful to the Foundation for Science and Technology (FCT, Portugal) and FEDER under Programme PT2020 for financiai support to CIMO (UID/AGR/00690/2013) and L. Barros contract; to FEDER-Interreg Espana-Portugal programme for financiai support through the project 0377_Iberphenol_6_E.]pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationZan, Renato André; Fernandes, Ângela; Jedoz, Stephanie; Taofiq, Oludemi; Calhelha, Ricardo C.; Pires, Tânia C.S.P.; Martins, Roberto Carlos Campos; Barros, Lillian; Ferreira, Isabel C.F.R. (2018). Garcínía brasiliensis leaves: Bioactive properties and phytochemical assessment. In XXIV Encontro Luso Galego de Química. Porto. ISBN 978-989-8124-24-1pt_PT
dc.identifier.isbn978-989-8124-24-1
dc.identifier.urihttp://hdl.handle.net/10198/18317
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectGarcínía brasiliensispt_PT
dc.titleGarcínía brasiliensis leaves: Bioactive properties and phytochemical assessmentpt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FAGR%2F00690%2F2013/PT
oaire.citation.conferencePlacePorto, Portugalpt_PT
oaire.citation.titleXXIV Encontro Luso Galego de Químicapt_PT
oaire.fundingStream5876
person.familyNameFernandes
person.familyNameCalhelha
person.familyNamePires
person.familyNameBarros
person.familyNameFerreira
person.givenNameÂngela
person.givenNameRicardo C.
person.givenNameTânia C.S.P.
person.givenNameLillian
person.givenNameIsabel C.F.R.
person.identifier2118829
person.identifier469085
person.identifier144781
person.identifier.ciencia-id2015-0434-AE7C
person.identifier.ciencia-idF313-E3CE-554E
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person.identifier.ciencia-id9418-CF95-9919
person.identifier.orcid0000-0002-0157-9873
person.identifier.orcid0000-0002-6801-4578
person.identifier.orcid0000-0002-3954-3833
person.identifier.orcid0000-0002-9050-5189
person.identifier.orcid0000-0003-4910-4882
person.identifier.ridJ-2172-2014
person.identifier.ridQ-2842-2018
person.identifier.ridJ-3600-2013
person.identifier.ridE-8500-2013
person.identifier.scopus-author-id6507978333
person.identifier.scopus-author-id57057440000
person.identifier.scopus-author-id35236343600
person.identifier.scopus-author-id36868826600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typeconferenceObjectpt_PT
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