Publication
Synthesis of Benzo[a]naphtho[2,3-c]xanthones from 2-styrylchromones
| dc.contributor.author | Tomé, Sara | |
| dc.contributor.author | Patoilo, Diana | |
| dc.contributor.author | Santos, Clementina M.M. | |
| dc.contributor.author | Silva, Artur | |
| dc.date.accessioned | 2013-03-12T10:40:37Z | |
| dc.date.available | 2013-03-12T10:40:37Z | |
| dc.date.issued | 2012 | |
| dc.description.abstract | 2-Styrylchromones, a small group of natural occurring chromones vinylogues of flavones (2-phenylchromones) have been ex tensively studied (both by synthesis and transformations)111 due to their known important biological activities. 121 Following our interest in 2-styrylchromones and exploiting its reactivity as synthons in the preparation of other type of compounds, we studied their reactivity as dienophile in the Diels-Alder reaction with ortho-benzoquinodimethanesY1 Another field of interest of our research group is the chemistry of xanthones. 141 This class of oxygen-containing heterocyclic compounds is also associated with a broad spectrum of pharmacological propertiesY1 The interesting biological profile of benzoxanthones 161 is an example that the tricyclic core of xanthones may represent a promising key in medicinal chemistry. In this communication we present a route towards the synthesis of benzo[a]naphtho[2,3-c]xanthones from 2-styrylchromones. Here we discuss the experimental procedures and reaction mechanisms of the Diels-Alder transformation of 2-styrylchromone 1 into the oxidized cycloadduct 3 and its subsequent photoinduced electrocyclization and oxidation that gave access to the desired benzo[a] naphtho[2,3- c]xanthone 4. | por |
| dc.identifier.citation | Tomé, Sara; Patoilo, Diana; Santos, Clementina M. M.; Silva, Artur (2012). Synthesis of Benzo[a]naphtho[2,3-c]xanthones from 2-styrylchromones. In 3º Encontro Nacional de Química Terapêutica. Aveiro | por |
| dc.identifier.uri | http://hdl.handle.net/10198/8241 | |
| dc.language.iso | eng | por |
| dc.peerreviewed | yes | por |
| dc.title | Synthesis of Benzo[a]naphtho[2,3-c]xanthones from 2-styrylchromones | por |
| dc.type | conference object | |
| dspace.entity.type | Publication | |
| oaire.citation.conferencePlace | Aveiro, Portugal | por |
| oaire.citation.title | 3º Encontro Nacional de Química Terapêutica | por |
| person.familyName | Santos | |
| person.givenName | Clementina M.M. | |
| person.identifier.ciencia-id | 9018-DB9C-C590 | |
| person.identifier.orcid | 0000-0003-4380-7990 | |
| person.identifier.scopus-author-id | 7201458663 | |
| rcaap.rights | openAccess | por |
| rcaap.type | conferenceObject | por |
| relation.isAuthorOfPublication | 64f662b6-775d-4ea0-bfd7-f527af0ac1a0 | |
| relation.isAuthorOfPublication.latestForDiscovery | 64f662b6-775d-4ea0-bfd7-f527af0ac1a0 |