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Insights into the phenolic composition and in vitro bioactivity of cardoon capitulum: a nutraceutical-oriented valorization study

2024Journal article Restricted access
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dc.contributor.authorMandim, Filipa
dc.contributor.authorPinela, José
dc.contributor.authorMarcelino, Sandra Andreia
dc.contributor.authorDias, Maria Inês
dc.contributor.authorBarracosa, Paulo
dc.contributor.authorIvanov, Marija
dc.contributor.authorSoković, Marina
dc.contributor.authorSantos-Buelga, Celestino
dc.contributor.authorBarros, Lillian
dc.date.accessioned2024-01-15T11:57:51Z
dc.date.available2024-01-15T11:57:51Z
dc.date.issued2024
dc.description.abstractThe capitulum constituents (stigma, corolla, bracts, pappus, and receptacle) of seven cardoon cultivars were studied for their polyphenolic composition and bioactive properties. Fifteen phenolic compounds were identified, secoiridoid, secoxyloganin, and apigenin-O-hexuronoside in higher concentrations. The bracts had the highest concentration of phenolic compounds, and the corolla had the greatest variety. The corolla of F4-1-4 and F1-34-1 cultivars, and bracts of F1-1-1, F1-19-4, and F4-37-1 cultivars revealed the greatest capacity to inhibit the thiobarbituric acid reactive substances formation (IC50 of 38 and 40.4 μg/mL, respectively). The corolla of F1-34-1 cultivar showed higher antihaemolytic activity than the positive control Trolox (IC50 5.5 vs. 20 μg/mL). Bracts of the F4-25-2 cultivar showed higher cytotoxic activity. No hepatotoxicity or anti-inflammatory effects were presented by the studied samples. These bioactivities exhibit a significative correlation with phenolic compounds, in particular flavonoids. Antimicrobial capacity was also observed, with all samples presenting higher antifungal potential than positive controls.pt_PT
dc.description.sponsorshipThe authors are grateful to the Foundation for Science and Technology (FCT, Portugal) for financial support through national funds FCT/MCTES (PIDDAC) to CIMO (UIDB/00690/2020 and UIDP/00690/ 2020) and SusTEC (LA/P/0007/2020), for the F. Mandim PhD grant (SFRH/BD/146614/2019), and the J. Pinela (CEECIND/01001/2018) and M.I. Dias and L. Barros contracts through individual and institutional scientific employment program contracts. The authors are also grateful to the Ministry of Education, Science and Technological Development of the Republic of Serbia (451-03-68/2022-14/200007). GIP-USAL was funded by Junta de Castilla y Léon (Spain) through Project SA093P20 and the Strategic Research Program for Units of Excellence (ref. CLU-2018-04).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMandim, Filipa; Pinela, José; Marcelino, Sandra Andreia; Dias, Maria Inês; Barracosa, Paulo; Ivanov, Marija; Soković, Marina; Santos-Buelga, Celestino; Barros, Lillian (2024). Insights into the phenolic composition and in vitro bioactivity of cardoon capitulum: a nutraceutical-oriented valorization study. Food Chemistry. ISSN 0308-8146. 435, p. 1-12pt_PT
dc.identifier.doi10.1016/j.foodchem.2023.137480pt_PT
dc.identifier.eissn1873-7072
dc.identifier.issn0308-8146
dc.identifier.urihttp://hdl.handle.net/10198/29182
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationMountain Research Center
dc.relationMountain Research Center
dc.relationAssociate Laboratory for Sustainability and Tecnology in Mountain Regions
dc.relationIntegrated strategies for the development of a novel functional beverage with sustainable production systems
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectCynara cardunculus L.pt_PT
dc.subjectCardoon cultivarspt_PT
dc.subjectPhenolic compoundspt_PT
dc.subjectIn vitro bioactivitiespt_PT
dc.subjectAntioxidant activitypt_PT
dc.subjectBiowaste reductionpt_PT
dc.titleInsights into the phenolic composition and in vitro bioactivity of cardoon capitulum: a nutraceutical-oriented valorization studypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleMountain Research Center
oaire.awardTitleMountain Research Center
oaire.awardTitleAssociate Laboratory for Sustainability and Tecnology in Mountain Regions
oaire.awardTitleIntegrated strategies for the development of a novel functional beverage with sustainable production systems
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00690%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F00690%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0007%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F146614%2F2019/PT
oaire.citation.endPage12pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleFood Chemistrypt_PT
oaire.citation.volume435pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
person.familyNameMandim
person.familyNamePinela
person.familyNameMarcelino
person.familyNameDias
person.familyNameBarros
person.givenNameFilipa
person.givenNameJosé
person.givenNameSandra Andreia
person.givenNameMaria Inês
person.givenNameLillian
person.identifier469085
person.identifier.ciencia-idF318-9049-EB99
person.identifier.ciencia-id771C-2B43-B108
person.identifier.ciencia-id2A13-4BE6-C7CF
person.identifier.ciencia-id9616-35CB-D001
person.identifier.orcid0000-0002-6494-2326
person.identifier.orcid0000-0001-7523-1637
person.identifier.orcid0000-0003-1490-9445
person.identifier.orcid0000-0001-8744-7814
person.identifier.orcid0000-0002-9050-5189
person.identifier.ridB-4466-2014
person.identifier.ridM-8242-2013
person.identifier.ridJ-3600-2013
person.identifier.scopus-author-id54392272800
person.identifier.scopus-author-id54388787000
person.identifier.scopus-author-id35236343600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
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