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Blood flow visualization and measurements in microfluidic devices fabricated by a micromilling technique

2015Journal article Open access
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dc.contributor.authorSinghal, Jaron
dc.contributor.authorPinho, Diana
dc.contributor.authorLopes, Raquel
dc.contributor.authorSousa, Patrícia C.
dc.contributor.authorGarcia, Valdemar
dc.contributor.authorSchütte, Helmut
dc.contributor.authorLima, Rui A.
dc.contributor.authorGassmann, Stefan
dc.date.accessioned2018-02-19T10:00:00Z
dc.date.accessioned2018-03-05T10:13:15Z
dc.date.available2018-01-19T10:00:00Z
dc.date.available2018-03-05T10:13:15Z
dc.date.issued2015
dc.description.abstractThe most common and used technique to produce microfluidic devices for biomedical applications is the soft-lithography. However, this is a high cost and time-consuming technique. Recently, manufacturers were able to produce milling tools smaller than 100 μm and consequently have promoted the ability of the micromilling machines to fabricate microfluidic devices capable of performing cell separation. In this work, we show the ability of a micromilling machine to manufacture microchannels down to 30 μm and also the ability of a microfluidic device to perform partial separation of red blood cells from plasma. Flow visualization and measurements were performed by using a high-speed video microscopy system. Advantages and limitations of the micromilling fabrication process are also presented.en_EN
dc.description.sponsorshipThe authors acknowledge the financial support provided by PTDC/SAU-ENB/116929/2010 and EXPL/EMS-SIS/ 2215/2013 from FCT (Science and Technology Foundation), COMPETE, QREN and European Union (FEDER). DP acknowledge the PhD scholarship SFRH/BD/89077/2012, and P.C. Sousa acknowledges the fellowship SFRH/BPD/75258/ 2010, all attributed by FCT.
dc.description.versioninfo:eu-repo/semantics/publishedVersionen_EN
dc.identifier.citationSinghal, Jaron; Pinho, Diana; Lopes, Raquel; Sousa, Patricia C.; Garcia, Valdemar; Schütte, Helmut; Lima, Rui; Gassmann, Stefan (2015). Blood flow visualization and measurements in microfluidic devices fabricated by a micromilling technique. Micro and Nanosystems. ISSN 1876-4029. 7:3,p. 148-153en_EN
dc.identifier.issn1876-4029
dc.identifier.urihttp://hdl.handle.net/10198/16154
dc.language.isoeng
dc.peerreviewedyesen_EN
dc.relationBIOMIMETIC - A biomimetic microdevice for the diagnosis of erythrocytes diseases based on their deformability
dc.relationBLOOD RHEOLOGY AND DEVELOPMENT OF BLOOD ANALOGUES
dc.subjectBiomedical applicationsen_EN
dc.subjectBlood cellsen_EN
dc.subjectCell-free layeren_EN
dc.subjectCells separationen_EN
dc.subjectMicrofluidic devicesen_EN
dc.subjectMicromillingen_EN
dc.titleBlood flow visualization and measurements in microfluidic devices fabricated by a micromilling techniqueen_EN
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleBIOMIMETIC - A biomimetic microdevice for the diagnosis of erythrocytes diseases based on their deformability
oaire.awardTitleBLOOD RHEOLOGY AND DEVELOPMENT OF BLOOD ANALOGUES
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876-PPCDTI/PTDC%2FSAU-ENB%2F116929%2F2010/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/COMPETE/EXPL%2FEMS-SIS%2F2215%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F89077%2F2012/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBPD%2F75258%2F2010/PT
oaire.fundingStream5876-PPCDTI
oaire.fundingStreamCOMPETE
oaire.fundingStreamSFRH
person.familyNamePinho
person.familyNameGarcia
person.familyNameLima
person.givenNameDiana
person.givenNameValdemar
person.givenNameRui A.
person.identifier.ciencia-id5214-ED0C-35E8
person.identifier.ciencia-idEE12-C3FB-349D
person.identifier.orcid0000-0002-3884-6496
person.identifier.orcid0000-0002-3941-2438
person.identifier.orcid0000-0003-3428-637X
person.identifier.ridH-5157-2016
person.identifier.scopus-author-id18437397800
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccessen_EN
rcaap.typearticleen_EN
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