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Insights into the phenolic composition and bioactive properties of Aloe vera flower

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dc.contributor.authorAñibarro-Ortega, Mikel
dc.contributor.authorPinela, José
dc.contributor.authorĆirić, Ana
dc.contributor.authorMocan, Andrei
dc.contributor.authorCaleja, Cristina
dc.contributor.authorFerreira, Olga
dc.contributor.authorBarros, Lillian
dc.contributor.authorSoković, Marina
dc.contributor.authorFerreira, Isabel C.F.R.
dc.date.accessioned2021-10-28T09:50:33Z
dc.date.available2021-10-28T09:50:33Z
dc.date.issued2019
dc.description.abstractAloe vera leaf has been subject of several scientific studies that aimed to characterize compositional and biological properties.1,2 However, the flower (Figure 1) remains an underexploited plant part. Aiming the prospection of bioactive phytochemicals in this plant matrix, this study was focused on the analysis of phenolic compounds and in vitro antioxidant, antimicrobial, and tyrosinase inhibition activities. A dried powder of Aloe vera flower underwent a solid-liquid extraction with an hydroethanolic mixture for 1 h, and the phenolic profile of the obtained dried extract was characterized by HPLC-DAD- ESI/MSn. Regarding biological activities, the antioxidant activity was evaluated by the cellular assays of OxHLIA and TBARS, using sheep erythrocytes and porcine brain cells as oxidizable substrates, respectively, and by the β-carotene bleaching inhibition assay; the antimicrobial activity was screened against skin-associated pathogenic bacteria and fungi; and the capacity to inhibit the activity of the tyrosinase enzyme was tested using L-DOPA as a substrate. It was found a phenolic profile constituted mainly by the flavonoids apigenin-6,8-C-diglucoside, apigenin-2’’-O-pentoxide-C-hexoside, apigenin-6-C-glucoside, and traces of luteolin glucoside derivatives (accounting for 93.4% of the extract), and by the phenolic acid 5-O-caffeoylquinic acid. As far as we know, it is the first time that some of these compounds are described in Aloe vera flower. No anthraquinone glycosides were detected in this part of the plant. The extract revealed an interesting antioxidant activity, being able to protect the erythrocyte membranes and the β-carotene from the free radical generated in the in vitro reaction system. It was also able to inhibit and kill multidrug-resistant bacteria such as Pseudomonas aeruginosa and Escherichia coli and some fungi, including Candida albicans. It also inhibited the tyrosinase enzyme activity, which translates its potential as a skin whitening agent. Based on these results, it was concluded that the Aloe vera flower could be exploited by industrial sectors interested in bio-based ingredients due to its composition in flavonoids and antioxidant, antimicrobial, and tyrosinase inhibition properties.pt_PT
dc.description.sponsorshipWe would like to thank the Foundation for Science and Technology (FCT, Portugal) for the research contracts of J. Pinela and L. Barros (national funding by FCT, through the institutional scientific employment program-contract). To the project AllNat for the contract of C. Caleja (Project AllNat POCI-01-0145-FEDER-030463). Also to the company “aCourela do Alentejo” for having supplied the plant material. Funding: This work was financially supported by the Project AllNat-POCI-01-0145-FEDER-030463 (PTDC/EQU-EPQ/30463/2017), funded by FEDER funds through COMPETE2020—Programa Operacional Competitividade e Internacionalização (POCI)—and by national funds through FCT/MCTES; and by the FEDER-Interreg España-Portugal programme through the project 0377_Iberphenol_6_E. We also thank the FCT and FEDER under the PT2020 Program for financial support to CIMO (UID/AGR/00690/2019); and the project TRANSCoLAB (0612_TRANS_CO_LAB_2_P).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationAñibarro-Ortega, Mikel; Pinela, José; Ciric, Ana; Mocan, Andrei; Caleja, Cristina; Ferreira, Olga; Barros, Lillian; Sokovic, Marina; Ferreira, Isabel C.F.R. (2019). Insights into the phenolic composition and bioactive properties of Aloe vera flower. In 11º Encontro Nacional de Cromatografia. Costa da Caparica. ISBN 978-989-8124-29-6
dc.identifier.isbn978-989-8124-29-6
dc.identifier.urihttp://hdl.handle.net/10198/24114
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationMountain Research Centre
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAloe verapt_PT
dc.subjectBiological propertiespt_PT
dc.titleInsights into the phenolic composition and bioactive properties of Aloe vera flowerpt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.awardNumberPTDC/EQU-EPQ/30463/2017
oaire.awardNumberUID/AGR/00690/2019
oaire.awardTitleMountain Research Centre
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/9471 - RIDTI/PTDC%2FEQU-EPQ%2F30463%2F2017/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FAGR%2F00690%2F2019/PT
oaire.citation.conferencePlaceCosta da Caparica, Portugalpt_PT
oaire.citation.title11º Encontro Nacional de Cromatografiapt_PT
oaire.fundingStream9471 - RIDTI
oaire.fundingStream6817 - DCRRNI ID
person.familyNameAñibarro-Ortega
person.familyNamePinela
person.familyNameCaleja
person.familyNameFerreira
person.familyNameBarros
person.familyNameFerreira
person.givenNameMikel
person.givenNameJosé
person.givenNameCristina
person.givenNameOlga
person.givenNameLillian
person.givenNameIsabel C.F.R.
person.identifier469085
person.identifier144781
person.identifier.ciencia-idC61D-DD88-73C7
person.identifier.ciencia-id771C-2B43-B108
person.identifier.ciencia-idE218-8DD3-4959
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person.identifier.ciencia-id9616-35CB-D001
person.identifier.ciencia-id9418-CF95-9919
person.identifier.orcid0000-0002-2835-5079
person.identifier.orcid0000-0001-7523-1637
person.identifier.orcid0000-0002-5769-8484
person.identifier.orcid0000-0001-8414-3479
person.identifier.orcid0000-0002-9050-5189
person.identifier.orcid0000-0003-4910-4882
person.identifier.ridB-4466-2014
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person.identifier.ridJ-3600-2013
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person.identifier.scopus-author-id54392272800
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person.identifier.scopus-author-id57203083219
person.identifier.scopus-author-id35236343600
person.identifier.scopus-author-id36868826600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typeconferenceObjectpt_PT
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