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Firefighters’ biomonitoring: impact of fire combat on levels of urinary monohydroxyl metabolites of polycyclic aromatic hydrocarbons

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dc.contributor.authorOliveira, Marta
dc.contributor.authorSlezakova, Klara
dc.contributor.authorFernandes, Adília
dc.contributor.authorTeixeira, João Paulo Fernandes
dc.contributor.authorDelerue-Matos, Cristina
dc.contributor.authorPereira, Maria do Carmo
dc.contributor.authorMorais, Simone
dc.date.accessioned2018-05-22T14:07:30Z
dc.date.available2018-05-22T14:07:30Z
dc.date.issued2018
dc.description.abstractFirefighters, one of the most hazardous occupations, are regularly exposed to complex mixtures of pollutants during fire combat. Polycyclic aromatic hydrocarbons (PAHs) are distributed between the gaseous and particulate phases of air: they are one of the most health-relevant pollutants released during fires because of their genotoxic, mutagenic, and carcinogenic properties [1]. This work aims to assess the impact of firefighting activities on firefighters’ total exposure to PAHs. Spot urine samples were collected in healthy and non-smoking firefighters before and after fire combat activities. Six urinary PAH metabolites (1-hydroxynaphthalene (1OHNaph), 1-hydroxyacenaphthene (1OHAce), 2-hydroxyfluorene (2OHFlu), 1-hydroxyphenanthrene (1OHPhen), 1-hydroxypyrene (1OHPy), and 3-hydroxybenzo[a]pyrene (3OHB[a]P)) were quantified by liquid chromatography with fluorescence detection [2-3]. Urinary 1OHNaph and 1OHAce were the predominant biomarkers of exposure in both non-exposed and exposed firefighters, accounting with 63-98% of total levels of PAH biomarkers (ΣOH-PAHs). 2OHFlu, 1OHPhe, and 1OHPy contributed with 1-17%, 1-13%, and 0.3-10% of ΣOH-PAHs, respectively. The PAH biomarker of carcinogenicity (3OHB[a]P) was not detected. Overall exposed firefighters presented levels of ΣOH-PAHs that were 2-35% higher than for non-exposed subjects. Urinary 2OHFlu seems to be the compound with the most pronounced increments in exposed firefighters. Urinary 1OHPy levels were always lower than the benchmark of 0.5 μmol/mol creatinine proposed by the American Conference of Governmental Industrial Hygienists. More studies assessing PAH biomarkers of exposure but also biomarkers of effect and susceptibility are needed to evaluate the impact of fire emissions on the health of firefighters.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationOliveira, M.; Slezakova, K.; Fernandes, Adília; Teixeira, J.P.; Delerue-Matos, C.; Pereira, M.C.; Morais, S. (2018). Firefighters’ biomonitoring: impact of fire combat on levels of urinary monohydroxyl metabolites of polycyclic aromatic hydrocarbons. In 1st Workshop on Human Biomonitoring in Portugal (1st HBM-PT). Lisboapt_PT
dc.identifier.urihttp://hdl.handle.net/10198/17670
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherInstituto Nacional de Saúde Doutor Ricardo Jorge (INSA)pt_PT
dc.relationIndoor and Outdoor Exposure to Ultrafine Particles: the Implications for Public Health
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectFirefighterspt_PT
dc.subjectUrinary monohydroxyl metabolitespt_PT
dc.subjectPolycyclic aromatic hydrocarbonspt_PT
dc.titleFirefighters’ biomonitoring: impact of fire combat on levels of urinary monohydroxyl metabolites of polycyclic aromatic hydrocarbonspt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.awardTitleIndoor and Outdoor Exposure to Ultrafine Particles: the Implications for Public Health
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FQUI%2F50006%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/OE/SFRH%2FBPD%2F105100%2F2014/PT
oaire.citation.conferencePlaceLisboapt_PT
oaire.citation.endPage43pt_PT
oaire.citation.startPage43pt_PT
oaire.citation.title1st Workshop on Human Biomonitoring in Portugal (1st HBM-PT)pt_PT
oaire.fundingStream5876
oaire.fundingStreamOE
person.familyNameFernandes
person.givenNameAdília
person.identifier.ciencia-id0514-76CD-8CCF
person.identifier.orcid0000-0003-1658-4509
person.identifier.ridV-8399-2017
person.identifier.scopus-author-id56489572200
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typeconferenceObjectpt_PT
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relation.isAuthorOfPublication.latestForDiscoverybdfceda8-18d6-4b63-b6f9-d3870cd0dbb0
relation.isProjectOfPublication40f15c30-b6e8-4474-ae1d-d7256c7af84e
relation.isProjectOfPublication004426ea-ac5d-41e2-8698-98ec0c0bdd50
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