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Baseline data and associations between urinary biomarkers of polycyclic aromatic hydrocarbons, blood pressure, hemogram, and lifestyle among wildland firefighters

2024Journal article Open access
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dc.contributor.authorBarros, Bela
dc.contributor.authorPaiva, Ana Margarida
dc.contributor.authorOliveira, Marta
dc.contributor.authorAlves, Sara Elisa Brás
dc.contributor.authorEsteves, Filipa
dc.contributor.authorFernandes, Adília
dc.contributor.authorVaz, Josiana A.
dc.contributor.authorSlezakova, Klara
dc.contributor.authorCosta, Solange
dc.contributor.authorTeixeira, João Paulo Fernandes
dc.contributor.authorMorais, Simone
dc.date.accessioned2024-05-16T16:23:24Z
dc.date.available2024-05-16T16:23:24Z
dc.date.issued2024
dc.description.abstractAvailable literature has found an association between firefighting and pathologic pathways leading to cardiorespiratory diseases, which have been linked with exposure to polycyclic aromatic hydrocarbons (PAHs). PAHs are highlighted as priority pollutants by the European Human Biomonitoring Initiative in occupational and non-occupational contexts. Methods This cross-sectional study is the first to simultaneously characterize six creatinine-adjusted PAHs metabolites (OHPAHs) in urine, blood pressure, cardiac frequency, and hemogram parameters among wildland firefighters without occupational exposure to fire emissions (> 7 days), while exploring several variables retrieved via questionnaires. Results Overall, baseline levels for total OHPAHs levels were 2 to 23-times superior to the general population, whereas individual metabolites remained below the general population median range (except for 1-hydroxynaphthalene+1-hydroxyacenaphtene). Exposure to gaseous pollutants and/or particulate matter during work-shift was associated with a 3.5-fold increase in total OHPAHs levels. Firefighters who smoke presented 3-times higher total concentration of OHPAHs than non-smokers (p < 0.001); non-smoker females presented 2-fold lower total OHPAHs (p = 0.049) than males. 1-hydroxypyrene was below the recommended occupational biological exposure value (2.5 mu g/L), and the metabolite of carcinogenic PAH (benzo(a)pyrene) was not detected. Blood pressure was above 120/80 mmHg in 71% of subjects. Firefighters from the permanent intervention team presented significantly increased systolic pressure than those who performed other functions (p = 0.034). Tobacco consumption was significantly associated with higher basophils (p = 0.01-0.02) and hematocrit (p = 0.03). No association between OHPAHs and blood pressure was found. OHPAHs concentrations were positively correlated with monocyte, basophils, large immune cells, atypical lymphocytes, and mean corpuscular volume, which were stronger among smokers. Nevertheless, inverse associations were observed between fluorene and pyrene metabolites with neutrophils and eosinophils, respectively, in non-smokers. Hemogram was negatively affected by overworking and lower physical activity. Conclusion This study suggests possible associations between urinary PAHs metabolites and health parameters in firefighters, that should be further assessed in larger groups.pt_PT
dc.description.sponsorshipThe authors are grateful to Fundação para a Ciência e a Tecnologia for financial support through national funds by BioFirEx: PCIF/SSO/0017/2018 (http://doi.org/10.54499/PCIF/SSO/0017/2018) and 2022.05381.PTDC (http://doi.org/10.54499/2022.05381.PTDC). BB (PhD grant 2020.07394.BD) and MO (scientific contract CEECIND/03666/2017; https://doi.org/10.54499/CEECIND/03666/2017/CP1427/CT0007) are thankful to Fundação para a Ciência e a Tecnologia, Ministério da Ciência, Tecnologia e Ensino Superior for their financial support. This work also received support by UIDB/50006/2020 (http://doi.org/10.54499/UIDB/50006/2020), UIDP/ 50006/2020 (http://doi.org/10.54499/UIDP/50006/2020), LA/P/0008/2020 (http://doi.org/10.54499/LA/P/0008/2020) by the Fundação para a Ciência e a Tecnologia (FCT-MCTES). The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This work was financed through project PCIF/SSO/0090/2019 (http://doi.org/10.54499/PCIF/SSO/0090/2019) by the Fundacao para a Ciencia e a Tecnologia, Ministerio da Ciencia, Tecnologia e Ensino Superior (FCT-MCTES), through national funds.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationBarros, Bela; Paiva, Ana Margarida; Oliveira, Marta, Alves, Sara; Esteves, Filipa; Fernandes, Adília; Vaz, Josiana A.; Slezakova, Klara; Costa, Solange; Teixeira, João P.; Morais, Simone (2024). Baseline data and associations between urinary biomarkers of polycyclic aromatic hydrocarbons, blood pressure, hemogram, and lifestyle among wildland firefighters. Frontiers in Public Health. EISSN 2296-2565. 12, p. 1-19pt_PT
dc.identifier.doi10.3389/fpubh.2024.1338435pt_PT
dc.identifier.eissn2296-2565
dc.identifier.urihttp://hdl.handle.net/10198/29787
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherFrontierspt_PT
dc.relationUIDP/ 50006/2020pt_PT
dc.relationNot Available
dc.relationAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
dc.relationAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
dc.relationFirefighting occupational exposure and early effects on the health of operational forces
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectFirefighters healthpt_PT
dc.subjectBiomonitoringpt_PT
dc.subjectBiomarkers of exposurept_PT
dc.subjectSmokingpt_PT
dc.subjectHydroxylated polycyclic aromatic hydrocarbonspt_PT
dc.subjectBiomarkers of effectpt_PT
dc.titleBaseline data and associations between urinary biomarkers of polycyclic aromatic hydrocarbons, blood pressure, hemogram, and lifestyle among wildland firefighterspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleNot Available
oaire.awardTitleAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
oaire.awardTitleAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
oaire.awardTitleFirefighting occupational exposure and early effects on the health of operational forces
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PCIF%2FSSO%2F0017%2F2018/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/Concurso de Projetos de I&D em Todos os Domínios Científicos - 2022/2022.05381.PTDC/PT
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oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F50006%2F2020/PT
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oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PCIF%2FSSO%2F0090%2F2019/PT
oaire.citation.endPage19pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleFrontiers in Public Healthpt_PT
oaire.citation.volume12pt_PT
oaire.fundingStream3599-PPCDT
oaire.fundingStreamConcurso de Projetos de I&D em Todos os Domínios Científicos - 2022
oaire.fundingStreamPOR_NORTE
oaire.fundingStreamCEEC IND 2017
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream3599-PPCDT
person.familyNameFernandes
person.familyNameVaz
person.givenNameAdília
person.givenNameJosiana A.
person.identifier.ciencia-id0514-76CD-8CCF
person.identifier.ciencia-id171B-88BA-64F5
person.identifier.orcid0000-0003-1658-4509
person.identifier.orcid0000-0002-6989-1169
person.identifier.ridV-8399-2017
person.identifier.scopus-author-id56489572200
person.identifier.scopus-author-id16305323200
project.funder.identifierhttp://doi.org/10.13039/501100001871
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project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
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project.funder.nameFundação para a Ciência e a Tecnologia
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