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Punica granatum L. bioresidues as a source of compounds with bioactive properties

2019Conference object Open access
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dc.contributor.authorCaleja, Cristina
dc.contributor.authorVeloso, Felipe da Silva
dc.contributor.authorPires, Tânia C.S.
dc.contributor.authorPinela, José
dc.contributor.authorCalhelha, Ricardo C.
dc.contributor.authorBarros, Lillian
dc.contributor.authorGenena, Aziza Kamal
dc.contributor.authorBarreira, João C.M.
dc.contributor.authorFerreira, Isabel C.F.R.
dc.date.accessioned2021-10-25T13:54:41Z
dc.date.available2021-10-25T13:54:41Z
dc.date.issued2019
dc.description.abstractPunica granatum L. (pomegranate), is a fruit that has been widely studied due to its composition in specific phenolic compounds, having also been described as displaying excellent bioactive properties (antioxidant, antimicrobial, and anti-inflammatory activity), with preventive action against some diseases [1,2]. Given that the inedible part of this fruit can represent up to about 50% of the total weight, this bio-waste has high potential as a source of bioactive compounds of interest [3]. Thus, this study compared different types of solvents in the extraction of phenolic compounds from the exocarp, mesocarp and pericarp of two pomegranate varieties: Mollar de Elche (yellow pomegranate) and Purple Queen (red pomegranate). Chemical characterization was performed by HPLC-DAD-ESI/MS and revealed the presence of fourteen phenolic compounds in the Mollar de Elche, highlighting punicalagin and galloyl-HHDP-glucose as the major compounds. The extracts of pomegranate Purple Queen showed the same 14 phenolic compounds, despite being present in lower amounts, but this cultivar revealed also three anthocyanins, which may justify the characteristic reddish color of its bark. Additionally, the antioxidant activity (inhibition of thiobarbituric acid reactive species formation in brain homogenates and inhibition of oxidative hemolysis, OxHLIA), antibacterial (against a panel of 5 Gram-positive bacteria and 3 Gram-negative bacteria, using the microdilution method), anti-inflammatory activity (rat macrophage cells), and cytotoxic potential (in human tumor cell lines by the sulforhodamine B method). Mollar de Elche stood out for its higher antioxidant and antibacterial activity, and cytotoxicity. In general, the different extracts obtained from the by-products of both pomegranate varieties represent a source of phenolic compounds that allow it to exhibit excellent bioactive properties with potential application in the food industry as a natural ingredient, which will allow valuing these bio-residues.pt_PT
dc.description.sponsorshipThe authors are grateful to the Foundation for Science and Technology (FCT, Portugal) and FEDER under Programme PT2020 for financial support to CIMO (UID/AGR/00690/2019); national funding by FCT, P.I., through the institutional scientific employment program-contract for L. Barros and R. Calhelha’s contract, though the celebration of program-contract foreseen in No. 4, 5 and 6 of article 23o of Decree-Law No. 57/2016, of 29th August, amended by Law No. 57/2017, of 19th July; research contract of C. Caleja (Project AllNatt, POCI- 01-0145-FEDER-030463); to FEDER-Interreg España-Portugal programme for financial support through the project 0377_Iberphenol_6_E. This work is funded by the European Regional Development Fund (ERDF) through the Regional Operational Program North 2020, within the scope of Project NORTE-01-0145-FEDER-023289: DeCodE and project Mobilizador Norte- 01-0247-FEDER-024479: ValorNatural®.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationCaleja, Cristina; Veloso, F.; Pires, Tânia C.S.P.; Pinela, José; Calhelha, Ricardo C.; Barros, Lillian; Genena, A.; Barreira, João C.M.; Ferreira, Isabel C.F.R. (2019). Punica granatum L. bioresidues as a source of compounds with bioactive properties. In XXV Encontro Galego-Portugués de Química. ISBN 978-84-09-16320-5pt_PT
dc.identifier.issn978-84-09-16320-5
dc.identifier.urihttp://hdl.handle.net/10198/24085
dc.language.isoporpt_PT
dc.peerreviewedyespt_PT
dc.relationMountain Research Centre
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectPunica granatum L.pt_PT
dc.titlePunica granatum L. bioresidues as a source of compounds with bioactive propertiespt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.awardTitleMountain Research Centre
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FAGR%2F00690%2F2019/PT
oaire.citation.conferencePlaceSantiago de Compostela, Espanhapt_PT
oaire.citation.titleXXV Encontro Galego-Portugues de Químicapt_PT
oaire.fundingStream6817 - DCRRNI ID
person.familyNameCaleja
person.familyNamePires
person.familyNamePinela
person.familyNameCalhelha
person.familyNameBarros
person.familyNameBarreira
person.familyNameFerreira
person.givenNameCristina
person.givenNameTânia C.S.P.
person.givenNameJosé
person.givenNameRicardo C.
person.givenNameLillian
person.givenNameJoão C.M.
person.givenNameIsabel C.F.R.
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person.identifier.ridQ-2842-2018
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project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typeconferenceObjectpt_PT
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