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Interplay Between Western Diet and Mammary Cancer: Data from a Chemically-induced Model in Wistar Rats

2024Journal article Open access
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dc.contributor.authorSilva, Jessica
dc.contributor.authorAires, Inês
dc.contributor.authorPeixoto, Francisco P.
dc.contributor.authorNeuparth, Maria João
dc.contributor.authorQueiroga, Felisbina
dc.contributor.authorSeixas, Fernanda
dc.contributor.authorFerreira, Rita
dc.contributor.authorFaustino-Rocha, Ana
dc.contributor.authorDuarte, José Alberto
dc.contributor.authorOliveira, Paula A.
dc.date.accessioned2024-12-20T16:34:33Z
dc.date.available2024-12-20T16:34:33Z
dc.date.issued2024
dc.description.abstractThis study aimed to investigate the influence of Western diet on mammary cancer in Wistar female rats, focusing on systemic responses and tumor development. Materials and Methods: Twenty-eight Wistar female rats were acclimatized and divided into four experimental groups (n=7 each): Western diet (WD), Western diet with N-methyl-N-nitrosourea (MNU) administration (WD+MNU), standard diet (CTR), and standard diet with MNU administration (CTR+MNU). MNU was administered intraperitoneally at 50 mg/kg at seven weeks of age to induce mammary cancer. The 20-week experiment involved monitoring animal weight, food and water intake. At the end of the study, rats were euthanized, and blood samples and organs were collected for hematological and plasma biochemical analysis, oxidative stress, and histo-pathological and immunobiological evaluations of the tumors. Results: No significant differences were found in body weight, composition, or organ weights, but the WD group showed reduced food and water intake and lower cholesterol levels. Leptin and adiponectin levels were higher in the WD+MNU group, suggestive of changes in appetite regulation. Histopathological analysis showed malignant tumors in both MNU-induced groups. However, WD groups had fewer tumors compared to the CTR+MNU group. Conclusion: WD led to higher feed efficiency and increased visceral adipose tissue but decreased systemic cholesterol and triglyceride levels. While this diet resulted in lower tumor incidence, the volume and weight of the tumors were higher. Additionally, the WD decreased ERα and progesterone receptor immunoexpression, while Ki-67 immunoexpression was elevated.pt_PT
dc.description.sponsorshipThis work was supported by national funds from the FCT – Portuguese Foundation for Science and Technology, under the projects UIDB/04033/2020 (CITAB, DOI: 10.54499/UIDB/04033/2020), LA/P/0126/2020 (INOV4AGRO, https://doi.org/10.54499/LA/P/0126/ 2020), UIDB/00772/2020 (CECAV, https://doi.org/10.54499/UIDB/ 00772/2020), LA/P/0059/2020 (AL4AnimalS, https://doi.org/10.54499/ LA/P/0059/2020), UIDB/00690/2020 (CIMO; https://doi.org/10.54499/ UIDB/00690/2020), and UIDP/00690/2020 (CIMO; https://doi.org/10. 54499/UIDP/00690/2020), and the doctoral grants awarded to J.S. (2020.07999.BD; https://doi.org/10.54499/2020.07999.BD) and T.A. (2023.01329.BD; https://doi.org/10.54499/2023.01329.BD).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSilva, Jessica; Azevedo, Tiago; Aires, Inês; Peixoto, Francisco; Neuparth, Maria J.; Queiroga, Felisbina L.; Seixas, Fernanda; Ferreira, Rita; Faustino-Rocha, Ana I.; Duarte, José Alberto; Oliveira, Paula A. (2024). Interplay Between Western Diet and Mammary Cancer: Data from a Chemically-induced Model in Wistar Rats. Anticancer Research. ISSN 0250-7005. 44:11, p. 4843-4856pt_PT
dc.identifier.doi10.21873/anticanres.17310pt_PT
dc.identifier.eissn1791-7530
dc.identifier.issn0250-7005
dc.identifier.urihttp://hdl.handle.net/10198/30779
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherInternational Institute of Anticancer Researchpt_PT
dc.relationCentre for the Research and Technology of Agro-Environmental and Biological Sciences
dc.relationInstitute for innovation, capacity building and sustainability of agri-food production
dc.relationVeterinary and Animal Science Research Centre
dc.relationAssociate Laboratory for Animal and Veterinary Sciences
dc.relationMountain Research Center
dc.relationMountain Research Center
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectBreast cancerpt_PT
dc.subjectLifestylept_PT
dc.subjectRodentpt_PT
dc.subjectHigh-fat dietpt_PT
dc.titleInterplay Between Western Diet and Mammary Cancer: Data from a Chemically-induced Model in Wistar Ratspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleCentre for the Research and Technology of Agro-Environmental and Biological Sciences
oaire.awardTitleInstitute for innovation, capacity building and sustainability of agri-food production
oaire.awardTitleVeterinary and Animal Science Research Centre
oaire.awardTitleAssociate Laboratory for Animal and Veterinary Sciences
oaire.awardTitleMountain Research Center
oaire.awardTitleMountain Research Center
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04033%2F2020/PT
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oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F00690%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/OE/2020.07999.BD/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//2023.01329.BD/PT
oaire.citation.endPage4856pt_PT
oaire.citation.issue11pt_PT
oaire.citation.startPage4843pt_PT
oaire.citation.titleAnticancer Researchpt_PT
oaire.citation.volume44pt_PT
oaire.fundingStream6817 - DCRRNI ID
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