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Further insights into chemical characterization through GC–MS and evaluation for anticancer potential of Dracaena draco leaf and fruit extracts

2012Journal article Restricted access
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dc.contributor.authorValente, Maria João
dc.contributor.authorPinho, P. Guedes de
dc.contributor.authorHenrique, Rui
dc.contributor.authorPereira, J.A.
dc.contributor.authorCarvalho, Márcia
dc.date.accessioned2016-11-30T16:48:09Z
dc.date.available2016-11-30T16:48:09Z
dc.date.issued2012
dc.description.abstractThe present study reports for the first time the amino acid and fatty acid compositions and the antitumoral activity of aqueous extracts obtained from Dracaena draco L. leaf and fruit. Metabolite profiles were determined by gas chromatography-ion trap-mass spectrometry (GC-IT-MS), with several amino acids, palmitic, linolenic and stearic acid being identified in the leaf extract, and only proline, oleic and stearic acid in the fruit extract. The in vitro antiproliferative activities of the extracts were tested against human colon (Caco-2), kidney (A-498), and liver (HepG2) cancer cell lines. In addition, primary cultures of normal and cancerous renal cells derived from kidney cancer patients were treated with D. draco extracts (0-400 μg/mL). Antiproliferative and cytotoxic effects were determined by the MTT assay. D. draco extracts inhibited proliferation of human colon and renal tumor cells in vitro, whereas no or weak effect was observed in HepG2 cells. Compared to the fruit extract, D. draco leaf extract exhibited stronger antiproliferative activity against all cancer cells. Our results indicate that D. draco, particularly the leaf, may be useful as a cancer chemopreventive and/or chemotherapeutic agent for colon and kidney cancers.pt_PT
dc.description.sponsorshipThis work has been supported by Fundação para a Ciência e a Tecnologia through Grant No. PEst-C/EQB/LA0006/2011pt_PT
dc.identifier.citationValente, Maria João; Pinho, P. Guedes de; Henrique, Rui; Pereira, J.A.; Carvalho, Márcia (2012). Further insights into chemical characterization through GC–MS and evaluation for anticancer potential of Dracaena draco leaf and fruit extracts. Food and Chemical Toxicology. ISSN 0278-6915. 50, p. 3847–3852pt_PT
dc.identifier.doi10.1016/j.fct.2012.03.050pt_PT
dc.identifier.issn0278-6915
dc.identifier.urihttp://hdl.handle.net/10198/13575
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationStrategic Project - LA 6 - 2011-2012
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectDracaena dracopt_PT
dc.subjectLeafpt_PT
dc.subjectFruitpt_PT
dc.subjectFatty acidspt_PT
dc.subjectAmino acidspt_PT
dc.subjectAntiproliferative activitypt_PT
dc.titleFurther insights into chemical characterization through GC–MS and evaluation for anticancer potential of Dracaena draco leaf and fruit extractspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleStrategic Project - LA 6 - 2011-2012
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6820 - DCRRNI ID/PEst-C%2FEQB%2FLA0006%2F2011/PT
oaire.citation.endPage3852pt_PT
oaire.citation.issue10pt_PT
oaire.citation.startPage3847pt_PT
oaire.citation.titleFood and Chemical Toxicologypt_PT
oaire.citation.volume50pt_PT
oaire.fundingStream6820 - DCRRNI ID
person.familyNamePereira
person.givenNameJosé Alberto
person.identifier.ciencia-id611F-80B2-A7C1
person.identifier.orcid0000-0002-2260-0600
person.identifier.ridL-6798-2014
person.identifier.scopus-author-id57204366348
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication7932162e-a2da-4913-b00d-17babbe51857
relation.isAuthorOfPublication.latestForDiscovery7932162e-a2da-4913-b00d-17babbe51857
relation.isProjectOfPublicationc40e3666-1466-44a3-b595-b3c38d27fa0b
relation.isProjectOfPublication.latestForDiscoveryc40e3666-1466-44a3-b595-b3c38d27fa0b

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