Polypharmacy and potentially inappropriate medication in elderly of Northern Portugal

Pinto, Isabel C.; Pereira, Fernando A.; Mateos-Campos, R.

Publication

Polypharmacy and potentially inappropriate medication in elderly of Northern Portugal

2015Conference poster

dc.contributor.author	Pinto, Isabel C.
dc.contributor.author	Pereira, Fernando A.
dc.contributor.author	Mateos-Campos, R.
dc.date.accessioned	2018-03-15T16:16:35Z
dc.date.available	2018-03-15T16:16:35Z
dc.date.issued	2015
dc.description.abstract	Introduction: The growing aging of population and increasing prevalence of chronic diseases require the simultaneous use of drugs, lead to the issue of polypharmacy and potentially interactions and inappropriate use. Aim: To characterize polymedicated elderly and related factors, identify potentially interactions and inappropriate medication in elderly. Material and Methods: This cross-sectional study was based on a questionnaire applied to 69 elderly (≥65 years) from northern Portugal. It was considered as polymedicated seniors taking ≥5 drugs. Beers list and the Delafuente classification were used to evaluate the therapeutic and possible interactions. It was used descriptive statistics and a model of binary regression, with a significance of 5%. The study was approved by Ethics Committee. Results: The sample consisted mainly of males (53.6% vs. 46.4%), aged between 66 and 99 years (mean 82.01), while 65.2% have more than 80 years. However, most elderly are not polymedicated (58%), on average 4.61 different drugs are administered per day (maximum=19), antihypertensives (36.2%) and antacids (30.04%) are the most prescribed. Hypertension and depression increase the risk of polymedication eightfold (p=0.004) and fivefold (p=0.011) respectively. Female gender seems increase the risk of polypharmacy threefold, although not statistically significant (p=0.102), and regarding age, the older age group (>85 years) seems reduces the risk of polypharmacy in 0.6 fold, but also not statistically significant. According with Delafuente classification, 1.4% of elderly has potentially drug interactions (Omeprazole and Iron salts). According to the list of Beers, 5.8% of seniors take drugs that classified as having some indications (hydroxyzine, amitriptyline). Conclusions: Regarding polypharmacy, 42% of elderly are polymedicated with an average of about 5 different drugs per day, antihypertensives and antacids the most prescribed. Hypertension and depression are highly associated with polypharmacy. We identified one potentially drug interaction and about 6% of elderly taking drugs that classified as having some indications.	pt_PT
dc.description.version	info:eu-repo/semantics/publishedVersion	pt_PT
dc.identifier.citation	Pinto, Isabel C.; Pereira, Fernando; Mateos-Campos, R. (2015). Polypharmacy and potentially inappropriate medication in elderly of Northern Portugal. In 12th Congress of the European Association for Clinical Pharmacology and Therapeutics. Madrid	pt_PT
dc.identifier.uri	http://hdl.handle.net/10198/16321
dc.language.iso	eng	pt_PT
dc.peerreviewed	yes	pt_PT
dc.publisher	European Association for Clinical Pharmacology and Therapeutics	pt_PT
dc.rights.uri	http://creativecommons.org/licenses/by/4.0/	pt_PT
dc.subject	Beers list	pt_PT
dc.subject	Delafuente classification	pt_PT
dc.subject	Elderly	pt_PT
dc.subject	Inappropriate medication in elderly	pt_PT
dc.subject	Medication interactions	pt_PT
dc.subject	Polypharmacy	pt_PT
dc.title	Polypharmacy and potentially inappropriate medication in elderly of Northern Portugal	pt_PT
dc.type	conference poster
dspace.entity.type	Publication
oaire.citation.conferencePlace	Madrid, España	pt_PT
oaire.citation.title	12th Congress of the European Association for Clinical Pharmacology and Therapeutics	pt_PT
person.familyName	Pinto
person.familyName	Pereira
person.givenName	Isabel C.
person.givenName	Fernando A.
person.identifier.ciencia-id	851B-247F-C650
person.identifier.ciencia-id	C51E-6B11-C82F
person.identifier.orcid	0000-0003-4745-6489
person.identifier.orcid	0000-0002-3294-3084
person.identifier.rid	A-5556-2018
person.identifier.scopus-author-id	57192927859
rcaap.rights	openAccess	pt_PT
rcaap.type	conferenceObject	pt_PT
relation.isAuthorOfPublication	751d74ab-e27c-4713-97ba-62cad38d1890
relation.isAuthorOfPublication	126ec14b-f8f1-4c9e-ada8-1f75a5502c8a
relation.isAuthorOfPublication.latestForDiscovery	751d74ab-e27c-4713-97ba-62cad38d1890