Publication
Bilirubin levels and redox status in a young healthy population
| dc.contributor.author | Rodrigues, Carina | |
| dc.contributor.author | Rocha, Susana | |
| dc.contributor.author | Nascimento, Henrique | |
| dc.contributor.author | Vieira, Emília | |
| dc.contributor.author | Santos, Rosário | |
| dc.contributor.author | Santos-Silva, Alice | |
| dc.contributor.author | Costa, Elísio | |
| dc.contributor.author | Bronze-da-Rocha, Elsa | |
| dc.date.accessioned | 2014-10-20T15:43:46Z | |
| dc.date.available | 2014-10-20T15:43:46Z | |
| dc.date.issued | 2013 | |
| dc.description.abstract | The additional TA repeat (c.-41_ -40dupTA) in the promoter of the uridine diphosphate glucuronosyltransferase (UGT1A1) gene is associated with a decrease in gene transcription, a decline in bilirubin conjugation and, therefore, with an increase in circulating unconjugated bilirubin (UCB) [1] . The TA repeat polymorphism is remarkably prevalent in the Caucasian white population and is the main cause of Gilbert’s syndrome [1] . Bilirubin, the key metabolic product of hemoglobin (Hb) catabolism, has antioxidant properties that seem to have a protective effect in oxidative stress conditions, such as in atherosclerosis, coronary heart disease, inflammation, and cancer [2] . Some studies showed that high levels of bilirubin can be toxic to neurons in newborn infants. | |
| dc.identifier.citation | Rodrigues, Carina; Rocha, Susana; Nascimento, Henrique; Vieira, Emília; Santos, Rosário; Santos-Silva, Alice; Costa, Elísio; Bronze-da-Rocha, Elsa (2013). Bilirubin levels and redox status in a young healthy population. Acta Haematologica. ISSN 0001-5792. 130:1, p. 57-60 | por |
| dc.identifier.doi | 10.1159/000346429 | |
| dc.identifier.issn | 0001-5792 | |
| dc.identifier.uri | http://hdl.handle.net/10198/10912 | |
| dc.language.iso | eng | por |
| dc.peerreviewed | yes | por |
| dc.publisher | karger, Allschwilerstrasse | por |
| dc.relation | SFRH/BD/42791/2007 | |
| dc.subject | Bilirubin | por |
| dc.subject | Redox status | por |
| dc.title | Bilirubin levels and redox status in a young healthy population | por |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.endPage | 60 | por |
| oaire.citation.startPage | 57 | por |
| oaire.citation.title | Acta Haematologica | por |
| oaire.citation.volume | 130 | por |
| person.familyName | Rodrigues | |
| person.givenName | Carina | |
| person.identifier.ciencia-id | C415-C677-0253 | |
| person.identifier.orcid | 0000-0001-9773-1413 | |
| rcaap.rights | restrictedAccess | por |
| rcaap.type | article | por |
| relation.isAuthorOfPublication | ef666665-6593-48be-bc48-6a1bb58bedbd | |
| relation.isAuthorOfPublication.latestForDiscovery | ef666665-6593-48be-bc48-6a1bb58bedbd |
Files
Original bundle
1 - 1 of 1
No Thumbnail Available
- Name:
- Bilirubin Levels and Redox Status in a Young.pdf
- Size:
- 124.66 KB
- Format:
- Adobe Portable Document Format
License bundle
1 - 1 of 1
No Thumbnail Available
- Name:
- license.txt
- Size:
- 1.75 KB
- Format:
- Item-specific license agreed upon to submission
- Description: