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Characterization of Liquid Dosage Forms of Atenolol and Enalapril Maleate for Oral and Enteral Feeding Administration

2024Artigo científico Acesso aberto
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dc.contributor.authorMota, Sandra
dc.contributor.authorTorres, Ana
dc.contributor.authorQuintas, Clara
dc.contributor.authorPeres, António M.
dc.contributor.authorFerreiro, Nuno Manuel
dc.contributor.authorCruz, Rebeca
dc.contributor.authorFerreira, Helena
dc.contributor.authorAlmeida, Isabel F.
dc.contributor.authorCasal, Susana
dc.date.accessioned2024-10-21T13:52:30Z
dc.date.available2024-10-21T13:52:30Z
dc.date.issued2024
dc.description.abstractThe limited availability of pharmaceutical formulations tailored for cardiovascular diseases in both pediatric and geriatric populations generates the need for compounded dosage forms to guarantee precise dosing and medication adherence. This study aimed to analyze the physicochemical properties and stability of formulations of atenolol and enalapril maleate prepared with a proprietary oral vehicle, SuspendIt®. To this end, palatability, injectability, pH, rheological behavior, and physical, microbiological, and chemical stability over a 180-day storage period at 25 ◦C and 5 ◦C were evaluated. Injectability tests confirmed the suitable use of both formulations for administration through enteral feeding tubes. By using a potentiometric electronic tongue, it was confirmed that the SuspendIt® vehicle effectively served as a bitter-blocking strategy for atenolol and enalapril maleate. Adequate stability throughout the storage period was confirmed in terms of the mechanical properties, pH, and effectiveness of the preservative system. The atenolol concentration remained above 90% of the initial amount, while the concentration of enalapril maleate decreased to 88% after 90 days of storage at 25 ◦C. In summary, the atenolol formulation maintained suitable chemical, physical, and microbiological stability after 180 days at both storage temperatures, while the enalapril maleate formulation remained stable up to 60 days at 25 ◦C and for 180 days at 5 ◦C.pt_PT
dc.description.sponsorshipThe authors received support and help fromthe Foundation for Science and Technology (FCT, Portugal) by national funds FCT/MCTES (PIDDAC) to Associate Laboratory Institute for Health and Bioeconomy—i4HB (DOI 10.54499/LA/P/0140/2020), to Research Unit on AppliedMolecular Biosciences—UCIBIO (DOI 10.54499/UIDB/04378/2020 and DOI 10.54499/UIDP/04378/2020), to CIMO (UIDB/00690/2020, https://doi.org/10.54499/UIDB/00690/2020; and UIDP/00690/2020, https://doi.org/10.54499/UIDP/00690/2020), toLASusTEC(LA/P/0007/2020) andtoLAQV-REQUIMTE (DOI 10.54499/LA/P/0008/2020,DOI 10.54499/UIDP/50006/2020 andDOI 10.54499/UIDB/50006/2020). Nuno Ferreiro acknowledges the Ph.D. research grant (2022.10072.BD) provided by FCT. Rebeca Cruz is gratefully supported by FCT (2022.00965.CEECIND). S.Mota acknowledges her Ph.D. research grant (2022.12487.BD) and A. Torres also acknowledges her Ph.D. research grant (2023.03685.BD), both fully supported by FCT.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMota, Sandra; Torres, Ana; Quintas, Clara; Peres, António M.; Ferreiro, Nuno; Cruz, Rebeca; Ferreira, Helena; Almeida, Isabel F.; Casal, Susana (2024). Characterization of Liquid Dosage Forms of Atenolol and Enalapril Maleate for Oral and Enteral Feeding Administration. Pharmaceuticals. ISSN 1424-8247. 17:8, p. 1-25pt_PT
dc.identifier.doi10.3390/ph17081052pt_PT
dc.identifier.issn1424-8247
dc.identifier.urihttp://hdl.handle.net/10198/30474
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationApplied Molecular Biosciences Unit
dc.relationApplied Molecular Biosciences Unit
dc.relationMountain Research Center - UIDB/00690/2020
dc.relationMountain Research Center - UIDP/00690/2020
dc.relationAssociate Laboratory for Sustainability and Tecnology in Mountain Regions - LA/P/0007/2020
dc.relationAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
dc.relationAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
dc.relationAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
dc.relationExtra virgin olive oil shelf-life prediction based on an integrated approach from farm to fork
dc.relationOXIGUT - OXIdized lipids and GUT balance: Finding sustainable solutions to protect food lipids and to improve human nutrition and health.
dc.relationMulti-Strategies to Improve Sustainability in the Cosmetic Product Life Cycle
dc.relationTopical treatment of rare forms of ichthyosis targeting disease pathophysiology
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectStabilitypt_PT
dc.subjectCompoundingpt_PT
dc.subjectOral formulationspt_PT
dc.subjectAtenololpt_PT
dc.subjectEnalapril maleatept_PT
dc.subjectEnteral feedingpt_PT
dc.subjectLiquid dosage formspt_PT
dc.titleCharacterization of Liquid Dosage Forms of Atenolol and Enalapril Maleate for Oral and Enteral Feeding Administrationpt_PT
dc.typejournal article
dspace.entity.typePublication
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oaire.awardNumber2022.00965.CEECIND/CP1724/CT0016
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oaire.awardTitleApplied Molecular Biosciences Unit
oaire.awardTitleApplied Molecular Biosciences Unit
oaire.awardTitleMountain Research Center - UIDB/00690/2020
oaire.awardTitleMountain Research Center - UIDP/00690/2020
oaire.awardTitleAssociate Laboratory for Sustainability and Tecnology in Mountain Regions - LA/P/0007/2020
oaire.awardTitleAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
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oaire.awardTitleAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
oaire.awardTitleExtra virgin olive oil shelf-life prediction based on an integrated approach from farm to fork
oaire.awardTitleOXIGUT - OXIdized lipids and GUT balance: Finding sustainable solutions to protect food lipids and to improve human nutrition and health.
oaire.awardTitleMulti-Strategies to Improve Sustainability in the Cosmetic Product Life Cycle
oaire.awardTitleTopical treatment of rare forms of ichthyosis targeting disease pathophysiology
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04378%2F2020/PT
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oaire.citation.endPage25pt_PT
oaire.citation.issue8pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titlePharmaceuticalspt_PT
oaire.citation.volume17pt_PT
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person.familyNamePeres
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