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Kaempferol: a key emphasis to its anticancer potential

2019Journal article Open access
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dc.contributor.authorImran, Muhammad
dc.contributor.authorSalehi, Bahare
dc.contributor.authorSharifi-Rad, Javad
dc.contributor.authorGondal, Tanweer
dc.contributor.authorSaeed, Farhan
dc.contributor.authorImran, Ali
dc.contributor.authorShahbaz, Muhammad
dc.contributor.authorFokou, Patrick
dc.contributor.authorKhan, Haroon
dc.contributor.authorGuerreiro, Susana G.
dc.contributor.authorMartins, Natália
dc.contributor.authorEstevinho, Leticia M.
dc.date.accessioned2020-06-09T08:16:57Z
dc.date.available2020-06-09T08:16:57Z
dc.date.issued2019
dc.description.abstractA marked decrease in human cancers, including breast cancer, bone cancer, and cervical cancer, has been linked to the consumption of vegetable and fruit, and the corresponding chemoprotective e ect has been associated with the presence of several active molecules, such as kaempferol. Kaempferol is a major flavonoid aglycone found in many natural products, such as beans, bee pollen, broccoli, cabbage, capers, cauliflower, chia seeds, chives, cumin, moringa leaves, endive, fennel, and garlic. Kaempferol displays several pharmacological properties, among them antimicrobial, anti-inflammatory, antioxidant, antitumor, cardioprotective, neuroprotective, and antidiabetic activities, and is being applied in cancer chemotherapy. Specifically, kaempferol-rich food has been linked to a decrease in the risk of developing some types of cancers, including skin, liver, and colon. The mechanisms of action include apoptosis, cell cycle arrest at the G2/M phase, downregulation of epithelial-mesenchymal transition (EMT)-related markers, and phosphoinositide 3-kinase/protein kinase B signaling pathways. In this sense, this article reviews data from experimental studies that investigated the links between kaempferol and kaempferol-rich food intake and cancer prevention. Even though growing evidence supports the use of kaempferol for cancer prevention, further preclinical and clinical investigations using kaempferol or kaempferol-rich foods are of pivotal importance before any public health recommendation or formulation using kaempferol.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationImran, Muhammad; Salehi, Bahare; Sharifi-Rad, Javad; Gondal, Tanweer; Saeed, Farhan; Imran, Ali; Shahbaz, Muhammad; Fokou, Patrick; Khan, Haroon; Guerreiro, Susana G.; Martins, Natália; Estevinho, Letícia M. (2019). Kaempferol: a key emphasis to its anticancer potential. Molecules. ISSN 1420-3049. 24:12, p. 1-16pt_PT
dc.identifier.doi10.3390/molecules24122277pt_PT
dc.identifier.issn1420-3049
dc.identifier.urihttp://hdl.handle.net/10198/22037
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/pt_PT
dc.subjectKaempferolpt_PT
dc.subjectPharmacokineticspt_PT
dc.subjectPharmacodynamicspt_PT
dc.subjectAntioxidantpt_PT
dc.subjectAnticancerpt_PT
dc.subjectChemopreventionpt_PT
dc.titleKaempferol: a key emphasis to its anticancer potentialpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage16pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleMoleculespt_PT
oaire.citation.volume24, 2277pt_PT
person.familyNameEstevinho
person.givenNameLetícia M.
person.identifier.ciencia-idBA14-09D6-A406
person.identifier.orcid0000-0002-9249-1948
person.identifier.scopus-author-id6506577664
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication4a1d5ba2-1854-4ca5-89a4-73f35e964df9
relation.isAuthorOfPublication.latestForDiscovery4a1d5ba2-1854-4ca5-89a4-73f35e964df9

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