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Influence of the maturation stages on the chemical composition and biological activity of cardoon seeds

2022Conference object Open access
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dc.contributor.authorMandim, Filipa
dc.contributor.authorPetropoulos, Spyridon Α.
dc.contributor.authorPinela, José
dc.contributor.authorDias, Maria Inês
dc.contributor.authorKostić, Marina
dc.contributor.authorSoković, Marina
dc.contributor.authorSantos-Buelga, Celestino
dc.contributor.authorFerreira, Isabel C.F.R.
dc.contributor.authorBarros, Lillian
dc.date.accessioned2024-02-21T17:57:09Z
dc.date.available2024-02-21T17:57:09Z
dc.date.issued2022
dc.description.abstractCynara cardunculus L., usually known as cardoon, is a Mediterranean herbaceous plant with diversified industrial applications. It is used in traditional medicine due to its several health-promoting effects, mainly associated with its chemical composition. Cardoon is also considered a functional food due to its richness in compounds with high added value and health benefits (e.g., phenolic acids, flavonoids, fiber, inulin)1. In the present study, the influence of the harvest stage of cardoon seeds was analyzed. Seeds samples of cultivated cardoon (C. cardunculus L. var. altilis) were collected in Greece at different maturation stages (samples S1 - S4). The individual profiles in tocopherols, free sugars, organic acids, and fatty acids were determined using chromatographic methodologies. Its hydroethanolic extracts were characterized in terms of phenolic composition and cytotoxic, anti-inflammatory, antioxidant, and antimicrobial activities. The polyphenolic profile was analyzed by HPLC-DAD-ESI/MS. Antioxidant capacity was measured through two cell-based assays, namely TBARS and OxHLIA. The cytotoxic potential was determined against four tumor cell lines and a non-tumor cell line (PLP2). For the anti- inflammatory activity, it was determined the extracts’ capacity to inhibit the formation of NO production. Finally, the antimicrobial activity was assessed by the microdilution method. Six phenolic compounds were tentatively identified, with their content increasing with the increasing maturation state. Mature seeds also demonstrated high content in lipids (23 g/100 g) and tocopherols (29.62 mg/100 g), as well as relevant cytotoxic (GI50 of 97 – 216 μg/mL), antioxidant (TBARS; IC50 = 5 μg/mL), and anti-inflammatory potential (IC50 = 148 μg/mL). Significant antibacterial and antifungal activities were also demonstrated, particularly for samples S3 and S1, respectively. Further studies are needed to better understand which compounds are responsible for the observed bioactivities and the mechanisms responsible for the corresponding effects.pt_PT
dc.description.sponsorshipTo the Foundation for Science and Technology (FCT, Portugal) for financial support to CIMO (UIDB/00690/2020 and UIDP/00690/2020) and SusTEC (LA/P/0007/2021); PhD grant of Filipa Mandim (SFRH/146614/2019) and J. Pinela (CEECIND/01011/2018), M.I. Dias and L. Barros contracts.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMandim, Filipa; Petropoulos, Spyridon A.; Pinela, José; Dias, Maria Inês; Kostic, Marina; Sokovic, Marina; Santos-Buelga, Celestino; Ferreira, Isabel C.F.R.; Barros, Lillian (2022). Influence of the maturation stages on the chemical composition and biological activity of cardoon seeds. In 12º Encontro Nacional de Cromatografia. Aveiro. ISBN 987-989-8124-37-1pt_PT
dc.identifier.isbn987-989-8124-37-1
dc.identifier.urihttp://hdl.handle.net/10198/29578
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSociedade Portuguesa de Químicapt_PT
dc.relationLA/P/0007/2021pt_PT
dc.relationMountain Research Center
dc.relationMountain Research Center
dc.relationIntegrated strategies for the development of a novel functional beverage with sustainable production systems
dc.relationNot Available
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectCynara cardunculus Lpt_PT
dc.titleInfluence of the maturation stages on the chemical composition and biological activity of cardoon seedspt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.awardTitleMountain Research Center
oaire.awardTitleMountain Research Center
oaire.awardTitleIntegrated strategies for the development of a novel functional beverage with sustainable production systems
oaire.awardTitleNot Available
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00690%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F00690%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F146614%2F2019/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/CEEC IND 2018/CEECIND%2F01011%2F2018%2FCP1578%2FCT0002/PT
oaire.citation.conferencePlaceAveiropt_PT
oaire.citation.title12º Encontro Nacional de Cromatografiapt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamCEEC IND 2018
person.familyNameMandim
person.familyNamePinela
person.familyNameDias
person.familyNameFerreira
person.familyNameBarros
person.givenNameFilipa
person.givenNameJosé
person.givenNameMaria Inês
person.givenNameIsabel C.F.R.
person.givenNameLillian
person.identifier144781
person.identifier469085
person.identifier.ciencia-idF318-9049-EB99
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person.identifier.ciencia-id2A13-4BE6-C7CF
person.identifier.ciencia-id9418-CF95-9919
person.identifier.ciencia-id9616-35CB-D001
person.identifier.orcid0000-0002-6494-2326
person.identifier.orcid0000-0001-7523-1637
person.identifier.orcid0000-0001-8744-7814
person.identifier.orcid0000-0003-4910-4882
person.identifier.orcid0000-0002-9050-5189
person.identifier.ridB-4466-2014
person.identifier.ridM-8242-2013
person.identifier.ridE-8500-2013
person.identifier.ridJ-3600-2013
person.identifier.scopus-author-id54392272800
person.identifier.scopus-author-id54388787000
person.identifier.scopus-author-id36868826600
person.identifier.scopus-author-id35236343600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typeconferenceObjectpt_PT
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