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Mushroom ethanolic extracts as cosmeceuticals ingredients: Safety and ex vivo skin permeation studies

2019Journal article Open access
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dc.contributor.authorTaofiq, Oludemi
dc.contributor.authorRodrigues, Francisca
dc.contributor.authorBarros, Lillian
dc.contributor.authorBarreiro, M.F.
dc.contributor.authorFerreira, Isabel C.F.R.
dc.contributor.authorOliveira, Beatriz
dc.date.accessioned2018-02-19T10:00:00Z
dc.date.accessioned2020-01-03T10:35:25Z
dc.date.available2018-01-19T10:00:00Z
dc.date.available2020-01-03T10:35:25Z
dc.date.issued2019
dc.description.abstractMushrooms are important sources of natural bioactive compounds that are increasingly used as cosmeceutical ingredients. In this context, ethanolic extracts were prepared from Ganoderma lucidum and Pleurotus ostreatus and tested by incorporation into base cosmetic creams. In vitro safety evaluation of the extracts and cosmetic formulations prepared therefore was carried out using the MTT and LDH assays in keratinocyte (HaCaT) and fibroblast (HFF-1) cell lines. Moreover, they were submitted to ex vivo skin permeation studies using a Franz diffusion apparatus with pig ear skin as permeation membrane. The results showed the absence of toxicity for keratinocytes and fibroblasts in a concentration dependent manner, which is indicative of the safety of these extracts for cosmeceutical ingredients purposes. Protocatechuic and syringic acids were the only compounds permeating from G. lucidum extract in the first 8 h of study, no penetration was observed for phenolic acids found in P. ostreatus extract and formulation. These results pointed out for the suitability of using mushroom extracts as skin care ingredients and may contribute for the valorisation of wastes generated by the mushroom processing industry, which can serve as raw-materials for the obtainment of the extracts.
dc.description.sponsorshipThe authors are grateful to the Foundation for Science and Technology and FEDER under Programme PT2020 for financial support to CIMO (UID/AGR/00690/2019) and Associate Laboratory LSRE-LCM (UID/EQU/50020/2019) funded by national funds through FCT/ MCTES (PIDDAC). This work is funded by the European Agricultural Fund for Rural Development (EAFRD), through the Rural Development Program (PDR2020), within the scope of Project MicoCoating (PDR2020-101-031472). Francisca Rodrigues is thankful for her postdoc research grant from the project Operação NORTE-01-0145- FEDER- 000011. This work received financial support from the European Union (FEDER funds through COMPETE), under the Partnership Agreement PT 2020, and National Funds (FCT, Foundation for Science and Technology) through project LAQV/UID/QUI/50006/ 2013 and NORTE-07-0124-FEDER-000069 – Food Science.
dc.description.versioninfo:eu-repo/semantics/publishedVersionen_EN
dc.identifier.citationTaofiq, Oludemi; Rodrigues, Francisca; Barros, Lillian; Barreiro, Maria F.; Ferreira, Isabel C.F.R.; Oliveira, M. Beatriz P.P. (2019). Mushroom ethanolic extracts as cosmeceuticals ingredients: Safety and ex vivo skin permeation studies. Food and Chemical Toxicology. ISSN 0278-6915. 127, p. 228-236en_EN
dc.identifier.doi10.1016/j.fct.2019.03.045en_EN
dc.identifier.issn0278-6915
dc.identifier.urihttp://hdl.handle.net/10198/19982
dc.language.isoeng
dc.peerreviewedyesen_EN
dc.subjectBioactive compoundsen_EN
dc.subjectCosmeceuticalsen_EN
dc.subjectCytotoxicityen_EN
dc.subjectMushroomsen_EN
dc.subjectSkin permeationen_EN
dc.titleMushroom ethanolic extracts as cosmeceuticals ingredients: Safety and ex vivo skin permeation studiesen_EN
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FQUI%2F50006%2F2013/PT
oaire.fundingStream5876
person.familyNameBarros
person.familyNameBarreiro
person.familyNameFerreira
person.givenNameLillian
person.givenNameFilomena
person.givenNameIsabel C.F.R.
person.identifier469085
person.identifier144781
person.identifier.ciencia-id9616-35CB-D001
person.identifier.ciencia-id3418-47D5-5746
person.identifier.ciencia-id9418-CF95-9919
person.identifier.orcid0000-0002-9050-5189
person.identifier.orcid0000-0002-6844-333X
person.identifier.orcid0000-0003-4910-4882
person.identifier.ridJ-3600-2013
person.identifier.ridL-9802-2014
person.identifier.ridE-8500-2013
person.identifier.scopus-author-id35236343600
person.identifier.scopus-author-id57188719717
person.identifier.scopus-author-id36868826600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccessen_EN
rcaap.typearticleen_EN
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