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Localized cancer photodynamic therapy approach based on core–shell electrospun nanofibers

2024Journal article Open access
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dc.contributor.authorCosta, Sofia M.
dc.contributor.authorLourenço, Leandro M.O.
dc.contributor.authorCalhelha, Ricardo C.
dc.contributor.authorCalejo, Isabel
dc.contributor.authorBarrias, Cristina C.
dc.contributor.authorFangueiro, Raul
dc.contributor.authorFerreira, Diana P.
dc.date.accessioned2024-09-30T08:49:02Z
dc.date.available2024-09-30T08:49:02Z
dc.date.issued2024
dc.description.abstractPhotodynamic therapy (PDT) has been considered a promising treatment for several types of cancer, including cervical cancer. Localized drug delivery systems (DDSs) based on nanofibers produced by electrospinning have emerged as a powerful platform to carry and deliver photosensitizers (PSs) onto or adjacent to the tumor site, thereby promoting higher therapeutic efficacy and reducing the side effects to healthy tissues associated with systemic administration. In this work, core–shell electrospun nanofibers were produced using biodegradable polymers, such as poly(vinyl alcohol) (PVA) and gelatin (Gel), to act as a localized DDS for the treatment of cervical cancer using PDT. The synthesized porphyrin (Por) was able to generate singlet oxygen (FD = 0.62) and displayed higher phototoxicity against tumor cells compared with healthy cells. The developed PVA–Gel membranes were fully characterized, revealing defect-free nanofibers with a core–shell structure. Different Por concentrations were added to the fibers’ core, and their presence and uniform distribution within the nanofibers were confirmed. The Por release profile from nanofibers showed an initial fast release stage, followed by continuous release for at least 9 days. The PVA–Gel + Por core–shell nanofibers exhibited a higher inhibition of cancer cell proliferation under light irradiation when compared to dark and a higher phototoxic effect against tumor cells compared with non-tumor cells. Overall, this study demonstrates the great potential of core–shell nanofibers to be used as localized DDSs of PSs for the treatment of cervical cancer.pt_PT
dc.description.sponsorshipThanks to the University of Minho, University of Aveiro, and FCT/MCTES (Fundaça˜o para a Cieˆncia e a Tecnologia and Ministe´rio da Cieˆncia, Tecnologia e Ensino Superior) for the financial support to 2C2T – Centre for Textile Science and Technology under the projects UID/CTM/00264/2020 on its components Base (https://doi.org/10.54499/UIDB/00264/2020) and programmatic (https://doi.org/10.54499/UIDP/00264/2020), LAQV-REQUIMTE (UIDB/50006/2020 and UIDP/50006/2020), and the project EndoSWITCH (PTDC/BTM-ORG/5154/2020) funded by FCT/MCTES through national funds. The authors are also thankful to Project DRI/India/0447/2020 (https://doi.org/10.54499/DRI/India/ 0447/2020). The authors are also grateful to the Foundation for Science and Technology (FCT, Portugal) for financial support through national funds FCT/MCTES (PIDDAC) to CIMO (UIDB/ 00690/2020 and UIDP/00690/2020) and SusTEC (LA/P/0007/2020); the contract of R. C. Calhelha through the institutional scientific employment program-contract. Sofia M. Costa is thankful to FCT PhD Scholarship (SFRH/BD/147517/2019) and Diana P. Ferreira to CEECIND/02803/2017.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationCosta, Sofia M.; Lourenço, Leandro M. O.; Calhelha, Ricardo C.; Calejo, Isabel; Barrias, Cristina C.; Fangueiro, Raul; Ferreira, Diana P. (2024). Localized cancer photodynamic therapy approach based on core–shell electrospun nanofibers. Materials Advances. ISSN 2633-5409. 5:16, p. 6489-6500pt_PT
dc.identifier.doi10.1039/D4MA00647Jpt_PT
dc.identifier.issn2633-5409
dc.identifier.urihttp://hdl.handle.net/10198/30292
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherRoyal Society of Chemistrypt_PT
dc.relationCentre for Textile Science and Technology
dc.relationCentre for Textile Science and Technology
dc.relationAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
dc.relationAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
dc.relationHarnessing endothelial plasticity for therapeutic vascularization of ischemic tissues: a bioengineering approach
dc.relationPersonal Protective equipment for active filtration of microorganisms based on electrospun nanofiber membranes<br><br>
dc.relationMountain Research Center
dc.relationMountain Research Center
dc.relationAssociate Laboratory for Sustainability and Tecnology in Mountain Regions
dc.relationNot Available
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectPhotodynamic therapypt_PT
dc.subjectCervical cancerpt_PT
dc.titleLocalized cancer photodynamic therapy approach based on core–shell electrospun nanofiberspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleCentre for Textile Science and Technology
oaire.awardTitleCentre for Textile Science and Technology
oaire.awardTitleAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
oaire.awardTitleAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
oaire.awardTitleHarnessing endothelial plasticity for therapeutic vascularization of ischemic tissues: a bioengineering approach
oaire.awardTitlePersonal Protective equipment for active filtration of microorganisms based on electrospun nanofiber membranes<br><br>
oaire.awardTitleMountain Research Center
oaire.awardTitleMountain Research Center
oaire.awardTitleAssociate Laboratory for Sustainability and Tecnology in Mountain Regions
oaire.awardTitleNot Available
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F00264%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00264%2F2020/PT
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oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0007%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F147517%2F2019/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/CEEC IND 2017/CEECIND%2F02803%2F2017%2FCP1458%2FCT0003/PT
oaire.citation.endPage6500pt_PT
oaire.citation.issue16pt_PT
oaire.citation.startPage6489pt_PT
oaire.citation.titleMaterials Advancespt_PT
oaire.citation.volume5pt_PT
oaire.fundingStream6817 - DCRRNI ID
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oaire.fundingStream3599-PPCDT
oaire.fundingStream3599-PPCDT
oaire.fundingStream6817 - DCRRNI ID
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oaire.fundingStreamCEEC IND 2017
person.familyNameCalhelha
person.givenNameRicardo C.
person.identifier.ciencia-idF313-E3CE-554E
person.identifier.orcid0000-0002-6801-4578
person.identifier.ridJ-2172-2014
person.identifier.scopus-author-id6507978333
project.funder.identifierhttp://doi.org/10.13039/501100001871
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rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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