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Special bioactivities of phenolics from Acacia dealbata l. with potential for dementia, diabetes and antimicrobial treatments

2022Journal article Open access
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dc.contributor.authorPaula, Vanessa B.
dc.contributor.authorPedro, Soraia I.
dc.contributor.authorCampos, Maria G.
dc.contributor.authorDelgado, Teresa
dc.contributor.authorEstevinho, Leticia M.
dc.contributor.authorAnjos, Ofélia
dc.date.accessioned2022-03-10T15:46:03Z
dc.date.available2022-03-10T15:46:03Z
dc.date.issued2022
dc.description.abstractSome diseases still need better therapeutic approaches, including the prevention of development. Natural resources are investigated with this purpose; among them, we decided to use an invasive plant as a main strategy. This will help in two ways: screening new compounds in flowers prevents the plant from causing widespread damage by controlling the dissemination and also obtains crude material for further applications. In the present study, flower extracts from Acacia dealbata Link harvested in Portugal were studied during three stages of flowering. Phenolic compounds were evaluated using HPLC/DAD and the total phenolics as the total flavonoids content was determined. The bioactivities screened were antioxidant potential, inhibitory activities of some enzymes (acetylcholinesterase, lipase and -glucosidase) and, to complete the screening, the inhibition of microbial growth was determined against Gram-negative and Gram-positive bacteria, as well as for yeasts. The data obtained suggested that the hydroethanolic extracts gave good results for all these biological activities and varied according to the maturation status of the flowers, with the early stage being the most active, which can be related to the chalcones content. This new approach will lead to the possible control of the invasive plant and also future perspective research for therapeutic purposes.pt_PT
dc.description.sponsorshipThis research was funded by project PCIF/GVB/0145/2018 (Acacia4fireprev). This work is also funded by National Funds through the FCT—Foundation for Science and Technology under the Projects UIDB/00239/2020 (CEF), (UI0204): UIDB/00313/2020 and UIDB/00690/2020 (CIMO).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationPaula, Vanessa B.; Pedro, Soraia I.; Campos, Maria G.; Delgado, Teresa; Estevinho, Letícia M.; Anjos, Ofélia (2022). Special bioactivities of phenolics from acacia dealbata l. With potential for dementia, diabetes and antimicrobial treatments. Applied Sciences. ISSN 2076-3417. 12:3, p. 1-16pt_PT
dc.identifier.doi10.3390/app12031022pt_PT
dc.identifier.issn2076-3417
dc.identifier.urihttp://hdl.handle.net/10198/25205
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationForest Research Centre
dc.relationCoimbra Chemistry Center
dc.relationMountain Research Center
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectInvasive speciespt_PT
dc.subjectFlowerspt_PT
dc.subjectAntioxidantpt_PT
dc.subjectMicrobial activitypt_PT
dc.subjectBioactivitypt_PT
dc.subjectEnzyme inhibitory potentialpt_PT
dc.subjectAcetylcholinesterasept_PT
dc.subjectLipasept_PT
dc.subjectα-glucosidasept_PT
dc.titleSpecial bioactivities of phenolics from Acacia dealbata l. with potential for dementia, diabetes and antimicrobial treatmentspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleForest Research Centre
oaire.awardTitleCoimbra Chemistry Center
oaire.awardTitleMountain Research Center
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PCIF%2FGVB%2F0145%2F2018/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00239%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00313%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00690%2F2020/PT
oaire.citation.issue3pt_PT
oaire.citation.startPage1022pt_PT
oaire.citation.titleApplied Sciencespt_PT
oaire.citation.volume12pt_PT
oaire.fundingStream3599-PPCDT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
person.familyNamePaula
person.familyNameEstevinho
person.givenNameVanessa B.
person.givenNameLetícia M.
person.identifier.ciencia-id5F16-A866-562D
person.identifier.ciencia-idBA14-09D6-A406
person.identifier.orcid0000-0001-7281-8598
person.identifier.orcid0000-0002-9249-1948
person.identifier.scopus-author-id6506577664
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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