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Characterization and bioactivity of copaiba essential oil carried in a self-nanoemulsifying drug delivery system

2024Journal article Restricted access
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dc.contributor.authorAmes-Sibin, Ana Paula
dc.contributor.authorChagas, Any C.
dc.contributor.authorFerreira, Sabrina B.S.
dc.contributor.authorMandim, Filipa
dc.contributor.authorFinimundy, Tiane C.
dc.contributor.authorCalhelha, Ricardo C.
dc.contributor.authorPeralta, Rosane M.
dc.contributor.authorSá-Nakanishi, Anacharis B. de
dc.contributor.authorBracht, Lívia
dc.contributor.authorBruschi, Marcos L.
dc.contributor.authorBracht, Adelar
dc.contributor.authorBarros, Lillian
dc.contributor.authorComar, Jurandir Fernando
dc.date.accessioned2024-01-24T12:32:46Z
dc.date.available2024-01-24T12:32:46Z
dc.date.issued2024
dc.description.abstractCopaiba essential oil (CEO) is the volatile part of copaiba balsam, which has been topically used for various inflammatory conditions. However, there are some concerns about the CEO safety for oral use. The lipophilic character of CEO also limits its application in the pharmaceutical field. This study prepared a selfnanoemulsifying drug delivery system (SNEDDS) containing CEO and evaluated its toxic effects against a primary culture from pig liver (PLP2) and Green monkey kidney cell line (Vero). The inhibition of oxide nitric production was also evaluated on RAW 264.7 macrophage cell line to access the anti-inflammatory effect. The CEO was extracted by hydrodistillation and β-caryophyllene accounted for 51.8% of the oil. The formulation (FSNEDDS) consisting of CEO, Cremophor and ethyl linoleate was characterized in relation to morphology, stability, rheology, simulated digestion and bioaccessibility in vitro. FSNEDDS displayed Newtonian flow behavior with viscosity depending only on temperature and, in an aqueous medium, it formed small spherical particles (<100 nm size diameter). The FSNEDDS showed higher oxidative stability than the non-formulated CEO. In the simulated digestion, FSNEDDS formed nanoemulsifying droplets in gastric phase and tiny micelles in intestinal phase, and a bioaccessibility of 63%. The FSNEDDS showed a superior anti-inflammatory activity (+11%) than non-formulated CEO and this beneficial concentration was achieved with a non-toxic concentration for none of the cell lines tested. In conclusion, FSNEDDS improves the physicochemical stability, bioaccessibility and bioactivity of CEO, and it could be a phytotherapic option for per oral administration to treat inflammatory diseases.pt_PT
dc.description.sponsorshipThe authors wish to thank the financial support of the Coordenaç˜ao de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) and of the Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq). The authors are grateful to the Foundation for Science and Technology (FCT, Portugal) for financial support through national funds FCT/MCTES (PIDDAC) to CIMO (UIDB/00690/2020 and UIDP/00690/ 2020) and SusTEC (LA/P/0007/2020). The authors also thank the National funding by FCT - Foundation for Science and Technology, through the institutional scientific employment program-contract with L. Barros and F. Mandim PhD grant (SFRH/BD/146614/2019).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationAmes-Sibin, Ana Paula; Chagas, Any C.; Ferreira, Sabrina B.S.; Mandim, Filipa; Finimundy, Tiane C.; Calhelha, Ricardo C.; Peralta, Rosane M.; Sá-Nakanishi, Anacharis B. de; Bracht, Lívia; Bruschi, Marcos L.; Bracht, Adelar; Barros, Lillian; Comar, Jurandir F. (2024). Characterization and bioactivity of copaiba essential oil carried in a self-nanoemulsifying drug delivery system. Journal of Drug Delivery Science and Technology. ISSN 1773-2247. 91, p. 1-13pt_PT
dc.identifier.doi10.1016/j.jddst.2023.105206pt_PT
dc.identifier.eissn2588-8943
dc.identifier.issn1773-2247
dc.identifier.urihttp://hdl.handle.net/10198/29347
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherEditions de Santept_PT
dc.relationMountain Research Center
dc.relationMountain Research Center
dc.relationAssociate Laboratory for Sustainability and Tecnology in Mountain Regions
dc.relationIntegrated strategies for the development of a novel functional beverage with sustainable production systems
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectCopaiba essential oilpt_PT
dc.subjectSNEDDSpt_PT
dc.subjectSimulated digestionpt_PT
dc.subjectNewtonian fluidpt_PT
dc.subjectBioaccessibilitypt_PT
dc.subjectAnti-inflammatory activitypt_PT
dc.titleCharacterization and bioactivity of copaiba essential oil carried in a self-nanoemulsifying drug delivery systempt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleMountain Research Center
oaire.awardTitleMountain Research Center
oaire.awardTitleAssociate Laboratory for Sustainability and Tecnology in Mountain Regions
oaire.awardTitleIntegrated strategies for the development of a novel functional beverage with sustainable production systems
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00690%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F00690%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0007%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F146614%2F2019/PT
oaire.citation.endPage13pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleJournal of Drug Delivery Science and Technologypt_PT
oaire.citation.volume91pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
person.familyNameMandim
person.familyNameFinimundy
person.familyNameCalhelha
person.familyNameBarros
person.givenNameFilipa
person.givenNameTiane C.
person.givenNameRicardo C.
person.givenNameLillian
person.identifier469085
person.identifier.ciencia-idF318-9049-EB99
person.identifier.ciencia-id2F18-67B1-776A
person.identifier.ciencia-idF313-E3CE-554E
person.identifier.ciencia-id9616-35CB-D001
person.identifier.orcid0000-0002-6494-2326
person.identifier.orcid0000-0003-3516-0795
person.identifier.orcid0000-0002-6801-4578
person.identifier.orcid0000-0002-9050-5189
person.identifier.ridJ-2172-2014
person.identifier.ridJ-3600-2013
person.identifier.scopus-author-id6507978333
person.identifier.scopus-author-id35236343600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
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