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Impact of cervicovaginal microbiome on the risk of cervical abnormalities development

2023Journal article Open access
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dc.contributor.authorRosário, Andreia
dc.contributor.authorSousa, Ana Isabel
dc.contributor.authorVarandas, Tatiana
dc.contributor.authorMarinho-Dias, Joana
dc.contributor.authorMedeiros, Rui
dc.contributor.authorMartins, Maria Gabriela
dc.contributor.authorMonteiro, Paula
dc.contributor.authorSousa, Hugo
dc.date.accessioned2011-12-28T15:04:58Z
dc.date.available2011-12-28T15:04:58Z
dc.date.issued2023
dc.description.abstractThe vaginal microbiome has emerged as potentially influencing the natural history of Human Papillomavirus (HPV) infections and their clinical impact. We aimed to characterize the vaginal microbiome in samples from 807 high-risk HPVs (Hr-HPV) positive women with a mean age of 41.45 +/- 10.79 years who participated in the Regional Cervical Cancer Screening Program from the Northern Region of Portugal. Microbiome analysis was performed with commercial kits for the detection of 21 microorganisms. The most frequent microorganisms were Ureaplasma parvum (52.5%), Gardnerella vaginalis (GV) (34.5%), Atopobium vaginae (AV) (32.6%), Lacto (30.7%), and Mycoplasma hominis (MH) (23.5%). The distribution according to age reveals that MH, Mega1, GV, BVab2, AV, and Mob were more prevalent in women older than 41 years of age (p < 0.050), while Lacto is significantly decreased in this group (23.5% vs. 39.4%, p < 0.001; RR = 0.47). The risk analysis showed that Hr-HPV-16/-18 and Hr-HPV-9val genotypes are associated with an increased risk of developing cervical abnormalities, while Lacto (p < 0.001; odd ratio [OR] = 0.33), GV (p = 0.0111; OR = 0.41), AV (p = 0.033; OR = 0.53) and Mob (p = 0.022; OR = 0.29) are associated with protection. Similar results were found for the risk of development atypical squamous cells cannot exclude HSIL/high-grade squamous intraepithelial lesion. Overall, the multivariate analysis confirmed that lactobacillus and bacteria associated with bacterial vaginosis (GV, AV, and Mob) are associated with protection against the development of cervical abnormalities. This study provides important data to be included in the future management of risk stratification for Hr-HPV-positive women.por
dc.identifier.citationRosário, Andreia; Sousa, Ana Isabel; Varandas, Tatiana; Marinho-Dias, Joana; Medeiros, Rui; Martins, Gabriela; Monteiro, Paula; Sousa, Hugo (2023). Impact of cervicovaginal microbiome on the risk of cervical abnormalities development. Journal of Medical Virology. eISSN 1096-9071. 95:5, p. 1-12por
dc.identifier.doi10.1002/jmv.28762
dc.identifier.eissn1096-9071
dc.identifier.issn0146-6615
dc.identifier.urihttp://hdl.handle.net/10198/6538
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherWileypor
dc.subjectCervical cancerpor
dc.subjectHuman papillomavirus (HPV)por
dc.subjectVaginal microbiomepor
dc.titleImpact of cervicovaginal microbiome on the risk of cervical abnormalities developmentpor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.titleJournal of Medical Virologypor
rcaap.rightsopenAccesspor
rcaap.typearticlepor

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