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Phytochemical composition and bioactive effects of Salvia africana, salvia officinalis 'Icterina' and Salvia mexicana aqueous Extracts

2019Journal article Open access
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dc.contributor.authorAfonso, Andrea Luísa Fernandes
dc.contributor.authorPereira, Olívia R.
dc.contributor.authorFernandes, Ângela
dc.contributor.authorCalhelha, Ricardo C.
dc.contributor.authorSilva, Artur
dc.contributor.authorFerreira, Isabel C.F.R.
dc.contributor.authorCardoso, Susana M.
dc.date.accessioned2018-02-19T10:00:00Z
dc.date.accessioned2020-01-03T18:02:17Z
dc.date.available2018-01-19T10:00:00Z
dc.date.available2020-01-03T18:02:17Z
dc.date.issued2019
dc.description.abstractIn the present study, aqueous extracts of Salvia africana, Salvia o cinalis ‘Icterina’ and Savia mexicana origin were screened for their phenolic composition and for antibacterial, antioxidant, anti-inflammatory and cytotoxic properties. The three aqueous extracts contained distinct phenolic compounds, with S. africana presenting the highest total levels (231.6 7.5 g/mg). Rosmarinic acid was the dominant phenolic compound in all extracts, yet that of S. africana origin was characterized by the present of yunnaneic acid isomers, which overall accounted for about 40% of total phenolics. In turn, S. o cinalis ‘Icterina’ extract presented glycosidic forms of apigenin, luteolin and scuttelarein, and the one obtained from S. mexicana contained several simple ca eic acid derivatives. S. africana aqueous extract exhibited high antioxidant potential in four methods, namely the DPPH (2,2-diphenyl-1-picrylhydrazyl) scavenging ability, iron-reducing power, inhibition of -carotene bleaching and of thiobarbituric acid reactive substances (TBARS), for which EC50 values were equal or only 1.3–3.1 higher than those of the standard compounds. Moreover, this extract was able to lower the levels of nitric oxide (NO) production in lipopolysaccharide (LPS)-activated RAW 264.7 macrophages (EC50 = 47.8 2.1 g/mL). In addition, the three sage aqueous extracts showed promising cytotoxic e ect towards hepatocellular HepG2, cervical HeLa, and breast carcinoma cells MCF-7. Overall this study highlights the potential of three little-exploited Salvia species, with commercial value for applications in food or pharmaceutical industries.
dc.description.sponsorshipFoundation for Science and Technology (FCT), the European Union, the National Strategic Reference Framework (QREN), the European Regional Development Fund (FEDER), and Operational Programme Competitiveness Factors (COMPETE), for funding the Organic Chemistry Research Unit (QOPNA) (FCT UID/QUI/00062/2019) and Mountain Research Center (CIMO) (UID/AGR/00690/2019), through national funds and where applicable co-financed by the FEDER, within the PT2020 Partnership Agreement. A. Fernandes and R. Calhelha thank the national funding by FCT, P.I., through the institutional scientific employment program-contract. Project AgroForWealth (CENTRO-01–0145-FEDER-000001), funded by Centro2020, through FEDER and PT2020, financed the research contract of Susana M. Cardoso. APC was sponsored by MDPI.
dc.description.versioninfo:eu-repo/semantics/publishedVersionen_EN
dc.identifier.citationAfonso, Andrea F.; Pereira, Olívia R.; Fernandes, Ângela; Calhelha, Ricardo C.; Silva, Artur M.S.; Ferreira, R. C.F.; Cardoso, Susana M. (2019). Phytochemical composition and bioactive effects of Salvia africana, salvia officinalis 'Icterina' and Salvia mexicana aqueous Extracts. Molecules. ISSN 1420-3049. 24, p. 1-13en_EN
dc.identifier.doi10.3390/molecules24234327en_EN
dc.identifier.urihttp://hdl.handle.net/10198/18755
dc.language.isoeng
dc.peerreviewedyesen_EN
dc.relationPT2020
dc.subjectAnti-inflammatoryen_EN
dc.subjectAntibacterialen_EN
dc.subjectAntioxidanten_EN
dc.subjectCytotoxicityen_EN
dc.subjectHigh performance liquid chromatographyen_EN
dc.subjectPhenolic compoundsen_EN
dc.subjectSalviaen_EN
dc.titlePhytochemical composition and bioactive effects of Salvia africana, salvia officinalis 'Icterina' and Salvia mexicana aqueous Extractsen_EN
dc.typejournal article
dspace.entity.typePublication
person.familyNameAfonso
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person.familyNameCalhelha
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person.givenNameAndrea Luísa Fernandes
person.givenNameOlívia R.
person.givenNameÂngela
person.givenNameRicardo C.
person.givenNameIsabel C.F.R.
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person.identifier.orcid0000-0002-0157-9873
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person.identifier.ridH-1049-2014
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rcaap.rightsopenAccessen_EN
rcaap.typearticleen_EN
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