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Advisor(s)
Abstract(s)
The gut microbiota establishes a mutually beneficial relationship with the host starting
from birth, impacting diverse metabolic and immunological processes. Dysbiosis, characterized by
an imbalance of microorganisms, is linked to numerous medical conditions, including gastrointestinal
disorders, cardiovascular diseases, and autoimmune disorders. This imbalance promotes the
proliferation of toxin-producing bacteria, disrupts the host’s equilibrium, and initiates inflammation.
Genetic factors, dietary choices, and drug use can modify the gut microbiota. However, there is
optimism. Several therapeutic approaches, such as probiotics, prebiotics, synbiotics, postbiotics,
microbe-derived products, and microbial substrates, aim to alter the microbiome. This review thoroughly
explores the therapeutic potential of these microbiota modulators, analysing recent studies
to evaluate their efficacy and limitations. It underscores the promise of microbiota-based therapies
for treating dysbiosis-related conditions. This article aims to ensure practitioners feel well-informed
and up to date on the most influential methods in this evolving field by providing a comprehensive
review of current research.
Description
Keywords
Dysbiosis Therapeutic interventions Probiotics and prebiotics New microbiome-modifying Gut modulation
Pedagogical Context
Citation
Pires, Lara; González-Paramás, Ana M.; Heleno, Sandrina A.; Calhelha, Ricardo C. (2024). Exploring Therapeutic Advances: A Comprehensive Review of Intestinal Microbiota Modulators. Antibiotics. ISSN 2079-6382. 13:8, p. 1-27
Publisher
MDPI