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Separation of Bioactive Compounds in Olive Leaf with a Pyridyl-Functionalized Adsorbent and Hydroalcoholic Solvents

2025Journal article Open access
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datacite.subject.fosCiências Agrárias::Agricultura, Silvicultura e Pescas
datacite.subject.sdg15:Proteger a Vida Terrestre
dc.contributor.authorBilalov, Elchin
dc.contributor.authorMartins, Cláudia Filipa
dc.contributor.authorCosta, Mário Rui
dc.contributor.authorDias, Rolando
dc.date.accessioned2025-04-24T15:47:51Z
dc.date.available2025-04-24T15:47:51Z
dc.date.issued2025
dc.description.abstractThe separation of different types of bioactive compounds in olive leaf is demonstrated with a tailored adsorbent functionalized with pyridyl moieties and sorption−desorption processes developed to use only hydroalcoholic solvents. The competitive binding isotherms of mixtures of vanillic acid, oleuropein, quercetin, maslinic, and oleanolic acids in water/ethanol solvents, with the composition ranging from 50/50 up to 100% ethanol, prove the feasibility of the separation of such different classes of molecules. The bioactive compounds in two industrial olive leaf extracts with different crude compositions were separated with the pyridyl-based polymer particles in packed columns, employing multicycle sorption/desorption processes. A polyphenol-rich extract was subjected to separation, resulting in the isolation of fractions containing varying concentrations of specific compounds. For example, a fraction enriched with oleuropein exhibited a concentration of approximately 80% (an enrichment factor of ∼4 in comparison with the crude extract), while glycosylated flavonoids were present at a concentration of around 60% in another fraction (an enrichment factor of ∼12). Additionally, aglycone flavonoids were present in fractions at a concentration of approximately 83% (an enrichment factor of ∼49). On the other hand, the separation of polyphenols and triterpene acids in an olive leaf extract with a high triterpene content was also demonstrated, with a ratio of flavonoids to triterpenoids of approximately 23 in isolated fractions, as compared to approximately 1 observed in the crude extract. The developed approach yielded luteolin with an enrichment factor of approximately 7. These novel achievements are intended to contribute to sustainability and a circular bioeconomy through the efficient industrial valorization of agricultural by products.eng
dc.description.sponsorshipThe authors acknowledge the support through the OLE- AF4VALUE project. This project received funding from the Bio-Based Industries Joint Undertaking under the European Union’s Horizon 2020 research and innovation programme under Grant Agreement No. 101023256. The authors also thank NATAC for providing the olive leaf extracts and aid with the identification by LC-MS of compounds they contained. Rolando Dias is grateful to the Foundation for Science and Technology (FCT, Portugal) for financial support through national funds FCT/MCTES (PIDDAC) to CIMO (UIDB/ 00690/2020 and UIDP/00690/2020) and SusTEC (LA/P/ 0007/2020). Mário Rui Costa acknowledges support from LA/ P/0045/2020 (ALiCE), UIDB/50020/2020, and UIDP/ 50020/2020 (LSRE-LCM), funded by national funds through FCT/MCTES (PIDDAC).
dc.identifier.citationBilalov, Elchin; Martins, Cláudia Filipa; Costa, Mário Rui; Dias, Rolando (2025). Separation of Bioactive Compounds in Olive Leaf with a Pyridyl-Functionalized Adsorbent and Hydroalcoholic Solvents. Industrial & Engineering Chemistry Research. ISSN 0888-5885. 64:10, p. 1-14
dc.identifier.doi10.1021/acs.iecr.4c04622
dc.identifier.eissn1520-5045
dc.identifier.issn0888-5885
dc.identifier.urihttp://hdl.handle.net/10198/34439
dc.language.isoeng
dc.peerreviewedyes
dc.publisherAmerican Chemical Society
dc.relationMountain Research Center
dc.relationMountain Research Center
dc.relationAssociate Laboratory for Sustainability and Tecnology in Mountain Regions
dc.relationALICE - Associate Laboratory in Chemical Engineering
dc.relationLaboratory of Separation and Reaction Engineering - Laboratory of Catalysis and Materials
dc.relationLaboratory of Separation and Reaction Engineering - Laboratory of Catalysis and Materials
dc.relation.ispartofIndustrial & Engineering Chemistry Research
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectEthanol
dc.subjectPolyphenolic compounds
dc.subjectBioactive compounds
dc.subjectDesorption process
dc.subjectEnrichment factors
dc.subjectFlavonoid
dc.subjectFunctionalized
dc.subjectLeaf extracts
dc.subjectOleuropein
dc.subjectOlive leaf
dc.subjectPyridyl
dc.subjectSorption/desorption
dc.subjectFlavonoids
dc.titleSeparation of Bioactive Compounds in Olive Leaf with a Pyridyl-Functionalized Adsorbent and Hydroalcoholic Solventseng
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleMountain Research Center
oaire.awardTitleMountain Research Center
oaire.awardTitleAssociate Laboratory for Sustainability and Tecnology in Mountain Regions
oaire.awardTitleALICE - Associate Laboratory in Chemical Engineering
oaire.awardTitleLaboratory of Separation and Reaction Engineering - Laboratory of Catalysis and Materials
oaire.awardTitleLaboratory of Separation and Reaction Engineering - Laboratory of Catalysis and Materials
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00690%2F2020/PT
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oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F50020%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F50020%2F2020/PT
oaire.citation.endPage14
oaire.citation.issue10
oaire.citation.startPage1
oaire.citation.titleIndustrial & Engineering Chemistry Research
oaire.citation.volume64
oaire.fundingStream6817 - DCRRNI ID
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oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
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