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Separation of Bioactive Compounds in Olive Leaf with a Pyridyl-Functionalized Adsorbent and Hydroalcoholic Solvents
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Orientador(es)
Resumo(s)
The separation of different types of bioactive compounds in olive leaf is demonstrated with a tailored adsorbent functionalized with pyridyl moieties and sorption−desorption processes developed to use only hydroalcoholic solvents. The competitive binding isotherms of mixtures of vanillic acid, oleuropein, quercetin, maslinic, and oleanolic acids in water/ethanol solvents, with the composition ranging from 50/50 up to 100% ethanol, prove the feasibility of the separation of such different classes of molecules. The bioactive compounds in two industrial olive leaf extracts with different crude compositions were separated with the pyridyl-based polymer particles in packed columns, employing multicycle sorption/desorption processes. A polyphenol-rich extract was subjected to separation, resulting in the isolation of fractions containing varying concentrations of specific compounds. For example, a fraction enriched with oleuropein exhibited a concentration of approximately 80% (an enrichment factor of ∼4 in comparison with the crude extract), while glycosylated flavonoids were present at a concentration of around 60% in another fraction (an enrichment factor of ∼12). Additionally, aglycone flavonoids were present in fractions at a concentration of approximately 83% (an enrichment factor of ∼49). On the other hand, the separation of polyphenols and triterpene acids in an olive leaf extract with a high triterpene content was also demonstrated, with a ratio of flavonoids to triterpenoids of approximately 23 in isolated fractions, as compared to approximately 1 observed in the crude extract. The developed approach yielded luteolin with an enrichment factor of approximately 7. These novel achievements are intended to contribute to sustainability and a circular bioeconomy through the efficient industrial valorization of agricultural by products.
Descrição
Palavras-chave
Ethanol Polyphenolic compounds Bioactive compounds Desorption process Enrichment factors Flavonoid Functionalized Leaf extracts Oleuropein Olive leaf Pyridyl Sorption/desorption Flavonoids
Contexto Educativo
Citação
Bilalov, Elchin; Martins, Cláudia Filipa; Costa, Mário Rui; Dias, Rolando (2025). Separation of Bioactive Compounds in Olive Leaf with a Pyridyl-Functionalized Adsorbent and Hydroalcoholic Solvents. Industrial & Engineering Chemistry Research. ISSN 0888-5885. 64:10, p. 1-14
Editora
American Chemical Society