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Purification of stilbenes from grape stems in a continuous process based on photo-molecularly imprinted adsorbents and hydroalcoholic solvents

2024Journal article Open access
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dc.contributor.authorBzainia, Amir
dc.contributor.authorIgrejas, Getúlio
dc.contributor.authorPereira, Maria João
dc.contributor.authorCosta, Mário Rui
dc.contributor.authorDias, Rolando
dc.date.accessioned2024-06-17T14:01:18Z
dc.date.available2024-06-17T14:01:18Z
dc.date.issued2024
dc.description.abstractThis study presents a sustainable method to purify stilbenes from residual grape stem biomass. This approach was experimentally validated through the use of a pilot size fixed-bed adsorption prototype for the automation of the purification process. Molecularly imprinted polymers, synthesized through photopolymerization at room temperature and incorporating the 4-vinylpyridine monomer, serve as adsorbents. The purification procedure leads to a significant enrichment, with a more than 22-fold increase in (E)-ε-viniferin and a 9-fold increase in (E)-resveratrol. High recoveries of 80.3% and 62.1% for (E)-ε-viniferin and (E)-resveratrol, respectively, were achieved. Notably, the use of eco-friendly water and ethanol mixtures distinguishes this method from others focused on stilbenes purification. This study further explores the variability of the stilbenes in the residual grape stems by analysing different varieties, emphasizing the complexity of the starting material of the purification process. The range of purities achieved for the fractions enriched with stilbenes (e.g., 12.8% for (E)-ε-viniferin and 3.4% for (E)-resveratrol) are suitable for direct use in controlling of Plasmopara viticola, the agent causing grapevine downy mildew. Furthermore, through compositional combination of these fractions, it is possible to conceive new stilbene-containing phytochemicals with improved anti-fungal activity. Therefore, the developed adsorbents and purification process, enabling the steady enrichment of stilbenes regardless of the unavoidable variability in the initial vine biomass, is a contribution towards the quest for more environmentally friendly and sustainable phytochemicals.pt_PT
dc.description.sponsorshipThe authors are thankful for the financial aid provided by “BacchusTech- Integrated Approach for the Valorization of Winemaking Residues” (POCI-01-0247-FEDER-069583), supported by the Competitiveness and Internationalization Operational Program (COMPETE 2020), under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (ERDF). A. Bzainia is grateful to the national funding by the Foundation for Science and Technology (FCT, Portugal) through the PhD grant of UI/BD/153688/2022. R.D. is grateful to the Foundation for Science and Technology (FCT, Portugal) for financial support through national funds FCT/MCTES (PIDDAC) to CIMO (UIDB/00690/2020 and UIDP/ 00690/2020) and SusTEC (LA/P/ 0007/2020). M.R.C. acknowledges the support by LA/P/0045/2020 (ALiCE), UIDB/50020/ 2020, and UIDP/50020/2020 (LSRE-LCM), funded by national funds through FCT/MCTES (PIDDAC). Getúlio Igrejas and Maria Jo˜ao Varanda Pereira work was supported by national funds through FCT/MCTES (PIDDAC): CeDRI, UIDB/05757/2020 (DOI: 10.54499/UIDB/05757/2020) and UIDP/05757/2020 (DOI: 10.54499/ UIDP/05757/2020); and SusTEC, LA/P/0007/2020 (DOI: 10.54499/ LA/P/0007/2020)pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationBzainia, Amir; Igrejas, Getúlio; Pereira, Maria João; Costa, Mário Rui P.F.N., Dias, Rolando (2024). Purification of stilbenes from grape stems in a continuous process based on photo-molecularly imprinted adsorbents and hydroalcoholic solvents. Separation and Purification Technology. ISSN 1383-5866. 349, p. 1-19pt_PT
dc.identifier.doi10.1016/j.seppur.2024.127798pt_PT
dc.identifier.issn1383-5866
dc.identifier.urihttp://hdl.handle.net/10198/29911
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationLA/P/0007/2020pt_PT
dc.relationMountain Research Center
dc.relationMountain Research Center
dc.relationAssociate Laboratory for Sustainability and Tecnology in Mountain Regions
dc.relationLaboratory of Separation and Reaction Engineering - Laboratory of Catalysis and Materials
dc.relationLaboratory of Separation and Reaction Engineering - Laboratory of Catalysis and Materials
dc.relationResearch Centre in Digitalization and Intelligent Robotics
dc.relationResearch Centre in Digitalization and Intelligent Robotics
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectStilbenespt_PT
dc.subjectContinuous processpt_PT
dc.subjectPhoto molecularly imprinted polymerspt_PT
dc.subjectHydroalcoholic-based purificationpt_PT
dc.subjectPhytochemicalspt_PT
dc.titlePurification of stilbenes from grape stems in a continuous process based on photo-molecularly imprinted adsorbents and hydroalcoholic solventspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleMountain Research Center
oaire.awardTitleMountain Research Center
oaire.awardTitleAssociate Laboratory for Sustainability and Tecnology in Mountain Regions
oaire.awardTitleLaboratory of Separation and Reaction Engineering - Laboratory of Catalysis and Materials
oaire.awardTitleLaboratory of Separation and Reaction Engineering - Laboratory of Catalysis and Materials
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oaire.citation.endPage19pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleSeparation and Purification Technologypt_PT
oaire.citation.volume349pt_PT
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person.familyNameBzainia
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person.identifier.ridM-8571-2013
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rcaap.typearticlept_PT
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