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Evaluation of parasite and host phenolic composition and bioactivities − The practical case of Cytinus hypocistis (L.) L. and Halimium lasianthum (Lam.) Greuter

2022Journal article Open access
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dc.contributor.authorSilva, Ana Rita
dc.contributor.authorAyuso, Manuel
dc.contributor.authorPereira, Carla
dc.contributor.authorDias, Maria Inês
dc.contributor.authorKostić, Marina
dc.contributor.authorCalhelha, Ricardo C.
dc.contributor.authorSoković, Marina
dc.contributor.authorGarcía, Pablo A.
dc.contributor.authorFerreira, Isabel C.F.R.
dc.contributor.authorBarros, Lillian
dc.date.accessioned2018-02-19T10:00:00Z
dc.date.accessioned2021-12-20T12:28:04Z
dc.date.available2018-01-19T10:00:00Z
dc.date.available2021-12-20T12:28:04Z
dc.date.issued2022
dc.description.abstractCytinus hypocistis (L.) L. is a comestible holoparasite with great potential for cosmeceutical application. Although its high tannin content has been associated with its bioactive and inhibitory enzyme properties, this is the first report establishing a relationship between parasite and host (Halimium lasianthum (Lam.) Greuter) phenolic profile and bioactive properties. Thus, five extracts (aerial and root extracts of non-parasited and parasited H. lasianthum and C. hypocistis) were evaluated. The tentative identification of both species comprises 39 phenolic compounds. Hydrolysable tannins and flavonoids were the main identified groups in C. hypocistis and H. lasianthum extracts, respectively. Regarding bioactivities, C. hypocistis exhibited excellent antioxidant results both in Oxidative Haemolysis (OxHLIA) and inhibition of Thiobarbituric Acid Reactive Substances Formation (TBARS). The tested extracts presented antimicrobial inhibition, anti-inflammatory activity, and effective cytotoxicity against tumour cells. C. hypocistis exhibited the lowest cytotoxicity on a non-tumour cell line. Principal Component Analysis (PCA) was a suitable approach to analyse differences among samples, explaining up to 67% of data variability and suggesting no similarities between parasite and host phenolic composition and bioactivities. Therefore, this comparative study emphasises the significance of both species as a source of biologically active compounds.en_EN
dc.description.sponsorshipThe authors are grateful to the Foundation for Science and Technology (FCT, Portugal) for financial support through national funds FCT/MCTES to CIMO (UIDB/00690/2020). A. R. Silva is grateful to FCT and FSE for her Doctoral Grant (SFRH/BD/145834/2019). L. Barros, C. Pereira, I. Dias, and R. C. Calhelha are grateful to F.C.T. and P.I. for their contracts through the institutional scientific employment programme. The authors are also thankful to the FEDER-Interreg Espa˜na-Portugal programme for financial support through the project TRANSCoLAB: 0612_TRANS_CO_LAB_2_P and to ERDF through the Regional Operational Program North 2020, within the scope of the Project GreenHealth - Norte-01–0145-FEDER-000042. This research was also funded by the Serbian Ministry of Education, Science and Technological Development (Contract No. 451–03-9/2021–14/200007).
dc.description.versioninfo:eu-repo/semantics/publishedVersionen_EN
dc.identifier.citationSilva, Ana Rita; Ayuso, Manuel; Pereira, Carla; Dias, Maria Inês; Kostić , Marina; Calhelha, Ricardo C.; Soković , Marina; García, Pablo A.; Ferreira, Isabel C.F.R.; Barros, Lillian (2022). Evaluation of parasite and host phenolic composition and bioactivities − The practical case of Cytinus hypocistis (L.) L. and Halimium lasianthum (Lam.) Greuter. Industrial Crops and Products. ISSN 0926-6690. 176, p. 1-10en_EN
dc.identifier.doi10.1016/j.indcrop.2021.114343en_EN
dc.identifier.issn0926-6690
dc.identifier.urihttp://hdl.handle.net/10198/24524
dc.language.isoeng
dc.peerreviewedyesen_EN
dc.relationnfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00690%2F2020/PT
dc.relationCytinus hypocistis L. L.: a case study for the development of an innovative, safe, and effective anti-photoaging cosmeceutical formulation
dc.subjectAntimicrobialen_EN
dc.subjectAntioxidanten_EN
dc.subjectCytotoxicityen_EN
dc.subjectFlavonoidsen_EN
dc.subjectTanninsen_EN
dc.subjectTyrosinase inhibitionen_EN
dc.titleEvaluation of parasite and host phenolic composition and bioactivities − The practical case of Cytinus hypocistis (L.) L. and Halimium lasianthum (Lam.) Greuteren_EN
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleCytinus hypocistis L. L.: a case study for the development of an innovative, safe, and effective anti-photoaging cosmeceutical formulation
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POR_NORTE/SFRH%2FBD%2F145834%2F2019/PT
oaire.fundingStreamPOR_NORTE
person.familyNameSilva
person.familyNameAyuso
person.familyNamePereira
person.familyNameDias
person.familyNameCalhelha
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person.familyNameBarros
person.givenNameAna Rita
person.givenNameManuel
person.givenNameCarla
person.givenNameMaria Inês
person.givenNameRicardo C.
person.givenNameIsabel C.F.R.
person.givenNameLillian
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project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccessen_EN
rcaap.typearticleen_EN
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