Repository logo
 
Publication

Long-term treatment with chaethomellic acid A reduces glomerulosclerosis and arteriolosclerosis in a rat model of chronic kidney disease

2017Journal article Open access
Simple item page
dc.contributor.authorNogueira, António José M.
dc.contributor.authorVala, Helena
dc.contributor.authorVasconcelos-Nóbrega, Cármen
dc.contributor.authorRocha, Ana Isabel Faustino
dc.contributor.authorPires, Carlos André
dc.contributor.authorColaço, Aura
dc.contributor.authorOliveira, Paula A.
dc.contributor.authorPires, Maria João
dc.date.accessioned2018-01-25T10:00:00Z
dc.date.accessioned2018-02-02T10:36:49Z
dc.date.available2018-01-25T10:00:00Z
dc.date.available2018-02-02T10:36:49Z
dc.date.issued2017
dc.description.abstractThe high prevalence of end-stage renal disease emphasizes the failure to provide therapies to effectively prevent and/or reverse renal fibrosis. Therefore, the aim of this study was to evaluate the effect of long-term treatment with chaethomellic acid A (CAA), which selectively blocks Ha-Ras farnesylation, on renal mass reduction-induced renal fibrosis. Male Wistar rats were sham-operated (SO) or subjected to 5/6 renal mass reduction (RMR). One week after surgery, rats were placed in four experimental groups: SO:SO rats without treatment (n = 13); SO + CAA: SO rats treated with CAA (n = 13); RMR:RMR rats without treatment (n = 14); and RMR + CAA:RMR rats treated with CAA (n = 13). CAA was intraperitoneally administered in a dose of 0.23 μg/kg three times a week for six months. Renal fibrosis was evaluated by two-dimensional ultrasonography and histopathological analysis. The kidneys of the RMR animals treated with CAA showed a significantly decrease in the medullary echogenicity (p < 0.05) compared with the RMR rats that received no treatment. Glomerulosclerosis and arteriolosclerosis scores were significantly lower (p < 0.001) in the RMR + CAA group when compared with the RMR group. There were no significant differences in interstitial fibrosis, interstitial inflammation and tubular dilatation scores between the RMR + CAA and RMR groups. These data suggest that CAA can be a potential future drug to attenuate the progression of chronic kidney disease.en_EN
dc.description.sponsorshipThis work is supported by : European Investment Funds by FEDER/COMPETE/POCI– Operacional Competitiveness and Internacionalization Programme, under Project POCI-01-0145-FEDER-006958 and National Funds by FCT - Portuguese Foundation for Science and Technology, under the project UID/AGR/04033/2013; and by European Investment Funds by FEDER/COMPETE/POCI– Operacional Competitiveness and Internacionalization Programme, under Project POCI-01-0145-FEDER-016728 and National Funds by FCT - Portuguese Foundation for Science and Technology, under the project PTDC/DTP-DES/6077/2014.
dc.description.versioninfo:eu-repo/semantics/publishedVersionen_EN
dc.identifier.citationNogueira, António; Vala, Helena; Vasconcelos-Nóbrega, Carmen; Faustino-Rocha, Ana Isabel; Pires, Carlos André; Colaço, Aura; Oliveira, Paula Alexandra; Pires, Maria João (2017). Long-term treatment with chaethomellic acid A reduces glomerulosclerosis and arteriolosclerosis in a rat model of chronic kidney disease. Biomedicine and Pharmacotherapy. ISSN 0753-3322. 96, p. 489-496en_EN
dc.identifier.doi10.1016/j.biopha.2017.09.137en_EN
dc.identifier.issn0753-3322
dc.identifier.urihttp://hdl.handle.net/10198/15501
dc.language.isoeng
dc.peerreviewedyesen_EN
dc.subject5/6 renal mass reduction modelen_EN
dc.subjectChaetomellic acid aen_EN
dc.subjectHa-Ras proteinen_EN
dc.subjectRenal fibrosisen_EN
dc.subjectWistar ratsen_EN
dc.titleLong-term treatment with chaethomellic acid A reduces glomerulosclerosis and arteriolosclerosis in a rat model of chronic kidney diseaseen_EN
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FAGR%2F04033%2F2013/PT
oaire.fundingStream5876
person.familyNameNogueira
person.givenNameAntónio
person.identifier.ciencia-id8A11-794E-36BD
person.identifier.orcid0000-0001-8912-7355
person.identifier.scopus-author-id55865568268
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccessen_EN
rcaap.typearticleen_EN
relation.isAuthorOfPublication648209a2-eec9-4bec-975a-32673e41b95c
relation.isAuthorOfPublication.latestForDiscovery648209a2-eec9-4bec-975a-32673e41b95c
relation.isProjectOfPublication3acb07e1-8183-43b8-8dfc-c0187a8741be
relation.isProjectOfPublication.latestForDiscovery3acb07e1-8183-43b8-8dfc-c0187a8741be

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
1.pdf
Size:
1.55 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.75 KB
Format:
Plain Text
Description:
Download

Collections

ESSa - Artigos em Revistas Indexados à WoS/Scopus