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Dalbergia ecastaphyllum leaf extracts: in vitro inhibitory against enzymes related to metabolic syndrome, inflammation and neurodegenerative diseases

2019Journal article Open access
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dc.contributor.authorMorais, Daniel Vieira
dc.contributor.authorMoreira, Manuela M.
dc.contributor.authorSilva, Fabiane de Lima
dc.contributor.authorCosta, Maria Angélica Carvalho
dc.contributor.authorDelerue-Matos, Cristina
dc.contributor.authorCarvalho, Carlos Alfredo Lopes de
dc.contributor.authorEstevinho, Leticia M.
dc.date.accessioned2020-06-09T14:36:34Z
dc.date.available2020-06-09T14:36:34Z
dc.date.issued2019
dc.description.abstractFor the first time, the anti-hemolytic activity and the enzyme inhibitory activities of Dalbergia ecastaphyllum leaves extracts were tested against α-amylase, α-glucosidase, lipase, acetylcholinesterase, butyrylcholinesterase, tyrosinase and hyaluronidase. The phenolic profile of the obtained extracts was also investigated by high-performance liquid chromatography with photodiode array detection (HPLC-PAD). The extracts showed inhibitory activity against all enzymes evaluated, with the highest inhibitory activity reported for the enzyme hyaluronidase (28.28 ± 2.43 to 72.19 ± 1.40 μg mL-1). The obtained extracts also demonstrate anti-hemolytic activity (52.22 ± 1.62 to 71.17 ± 1.82%). Among the phenolic compounds identified, protocatechuic, vanillic and β-resorcylic acids were the most abundant (1.13 ± 0.06 to 2.53 ± 0.06, 0.90 ± 0.06 to 2.19 ± 0.06 and 1.03 ± 1.62 to 22.11 ± 1.62 mg L-1, respectively). In the statistical analysis, a significant correlation was found between the flavonoids content and all enzymes inhibitory activities. The present study showed that D. ecastaphyllum leaves extracts may have the potential to be used in the therapeutic treatment of several diseases such as Alzheimer, Parkinson, type 2 diabetes mellitus, hyperglycemia, and pigmentation, as well as those associated with oxidative stress.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMorais, Daniel V.; Moreira, Manuela M.; Silva, Fabiane Lima; Costa, Maria Angélica Carvalho; Delerue-Matos, Cristina; Carvalho, Carlos Alfredo Lopes de:; Estevinho, Leticia M. (2019). Dalbergia ecastaphyllum leaf extracts: in vitro inhibitory against enzymes related to metabolic syndrome, inflammation and neurodegenerative diseases. Acta Scientiarum - Biological Sciences. ISSN 1679-9283. 41:1, p. 1-10pt_PT
dc.identifier.doi10.4025/actascibiolsci.v41i1.46622pt_PT
dc.identifier.issn1679-9283
dc.identifier.urihttp://hdl.handle.net/10198/22049
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/pt_PT
dc.subjectAcetylcholinesterasept_PT
dc.subjectα-glucosidasept_PT
dc.subjectHyaluronidasept_PT
dc.subjectPreclinical researchpt_PT
dc.titleDalbergia ecastaphyllum leaf extracts: in vitro inhibitory against enzymes related to metabolic syndrome, inflammation and neurodegenerative diseasespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage10pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleActa Scientiarum. Biological Sciencespt_PT
oaire.citation.volume41pt_PT
person.familyNameEstevinho
person.givenNameLetícia M.
person.identifier.ciencia-idBA14-09D6-A406
person.identifier.orcid0000-0002-9249-1948
person.identifier.scopus-author-id6506577664
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication4a1d5ba2-1854-4ca5-89a4-73f35e964df9
relation.isAuthorOfPublication.latestForDiscovery4a1d5ba2-1854-4ca5-89a4-73f35e964df9

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