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Effect of chaethomellic acid on renal function in a rat model of chronic renal failure

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dc.contributor.authorNogueira, António José M.
dc.contributor.authorFonte, Elizabete
dc.contributor.authorOliveira, Paula A.
dc.contributor.authorColaço, Bruno Jorge
dc.contributor.authorLópez-Novoa, Jose
dc.contributor.authorMega, Carmén
dc.contributor.authorColaço, Aura
dc.contributor.authorPires, Maria João
dc.date.accessioned2014-09-26T07:27:39Z
dc.date.available2014-09-26T07:27:39Z
dc.date.issued2013
dc.description.abstractTo study the effect of chronic treatment with chaethomellic acid (CA), a highly specific inhibitor of ras farnesyl-protein transferase, on the renal function of rats with renal failure induced by renal mass reduction. Male Wistar rats were subjected to 5/6 nephrectomy (RMR) or sham-operated (SO). One week after surgery, rats have been placed in four experimental groups: RMR: rats without treat- ment (n=13); RMR+CA: rats treated with CA (n=13); SO: rats without treatment (n=13); SO+AC: rats treated with CA (n=13). CA was intraperitoneally administered in a dose of 0.23 g/Kg three times a week for 6 months. Creatinine, blood urea nitrogen (BUN) and protein were measured in serum and/or urine by routine laboratory techniques. BUN, creatinine, and proteinuria were significantly lower and creatinine clearance was significantly higher in SO and SO+AC groups when compared with RMR and RMR+AC groups. There were no differ- ences in creatinine, proteinuria and creatinine clearance between RMR and RMR+AC groups. Anyway, RMR+AC group showed significant lower BUN and lower creatinine and proteinuria, and higher creatinine clearance than RMR group. In a model of renal failure induced by RMR, 6 months of treatment with CA may have some beneficial effect on renal function.por
dc.identifier.citationNogueira, António José M.; Fonte, Elizabete; Oliveira, Paula; Colaço, Bruno; López-Novoa, Jose; Mega, Carmén; Colaço, Aura; Pires, Maria( 2013) - Effect of chaethomellic acid on renal function in a rat model of chronic renal failure. . In 25 th European Congress of Pathology. Lisboapor
dc.identifier.urihttp://hdl.handle.net/10198/10610
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherEuropean Society of Pathologypor
dc.subjectRatpor
dc.subjectkidneypor
dc.titleEffect of chaethomellic acid on renal function in a rat model of chronic renal failurepor
dc.typeconference poster
dspace.entity.typePublication
oaire.citation.conferencePlaceLisboapor
oaire.citation.title25 th European Congress of Pathologypor
person.familyNameNogueira
person.givenNameAntónio José M.
person.identifier.ciencia-id8A11-794E-36BD
person.identifier.orcid0000-0001-8912-7355
person.identifier.scopus-author-id55865568268
rcaap.rightsopenAccesspor
rcaap.typeconferenceObjectpor
relation.isAuthorOfPublication648209a2-eec9-4bec-975a-32673e41b95c
relation.isAuthorOfPublication.latestForDiscovery648209a2-eec9-4bec-975a-32673e41b95c

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