| Name: | Description: | Size: | Format: | |
|---|---|---|---|---|
| 1.61 MB | Adobe PDF |
Authors
Advisor(s)
Abstract(s)
Os produtos à base de plantas são frequentemente usados em dermatologia e, apesar do número de estudos ser reduzido, existe evidência para o uso destes na psoríase, acne, dermatite atópica e outros problemas dermatológicos. Nos dias de hoje, estes produtos à base de plantas são muito requisitados para este objetivo, pois acredita-se que muitas vezes são a única opção para tratar este tipo de problemas.
Este trabalho incidiu sobre a psoríase, uma doença inflamatória de pele, cujas lesões eritemato-escamosas se caracterizam por uma elevada proliferação celular e por padrões anormais de diferenciação dos queratinócitos, além de envolver alterações bioquímicas, imunológicas e vasculares. Foram abordados os aspetos benéficos da utilização de plantas medicinais na psoríase, assim como a sua incorporação em nanocosméticos. A Nanocosmética veicula ativos ou outros ingredientes nanoestruturados nas formulações e apresenta propriedades superiores quanto à sua performance em comparação com produtos convencionais.
A forma farmacêutica utilizada foi a nanoemulsão, por apresentar mais benefícios neste estudo. Os óleos de Calendula officinalis L. e Copaifera reticulata Duncke e o óleo essencial de Matricaria recutita L. foram utilizados nas nanoemulsões por possuírem grande poder anti-inflamatório importante no tratamento da psoríase.
Ao longo do trabalho, foram desenvolvidas várias formulações de nanoemulsões (com diferentes percentagens de fase aquosa e oleosa), com o objetivo de alcançar uma nanoemulsão estável, com as características desejadas a nível organolético e de tamanho de partícula. As nanoemulsões foram desenvolvidas na Indústria Farmacêutica Labialfarma (Laboratório de Produtos Farmacêuticos e Nutracêuticos), mais precisamente no Departamento de Investigação e Desenvolvimento Galénico, do qual faço parte. Toda a investigação, testes de estabilidade e medições de nanopartículas necessários para o desenvolvimento desta dissertação foram também realizados na Labialfarma.
As nanoemulsões que apresentaram melhores resultados de estabilidade, coincidiram com as formulações com melhores características organoléticas e menor tamanho de partícula.
Herbal and phytotherapeutical products are often used in dermatology, and, despite the reduced number of published studies, there is evidence for their use in psoriasis, acne, atopic dermatitis and other dermatological problems. In our days, some of these herbal products are highly required for this purpose, being often the only option to treat this disease. This dissertation focused on psoriasis, an inflammatory skin disease in which the erythemato-squamous lesions are characterized by a high cellular proliferation and by abnormal patterns of keratinocyte’s differentiation, in addition to biochemical, immunological and vascular abnormalities. Benefits of the use of medicinal plants in psoriasis, as well as their incorporation in nanocosmetics were assessed. The nanocosmetics industry provides active principles or other nanostructured ingredients to the formulations, and shows superior properties, in terms of performance, compared to conventional products. Nanoemulsion was the pharmaceutical form used due to the higher benefits to the present study. The oils of Calendula officinalis L. and Copaifera reticulata Duncke, and the essential oil of Matricaria recutita L. were used in the nanoemulsions as they hold great anti-inflammatory power, significant in the treatment of psoriasis. Throughout the work, various formulations of nanoemulsions (with different percentages of water and oil phase) were developed, in order to achieve stable nanoemulsions, with the desired organoleptic characteristics and particle size levels. The nanoemulsions were developed at the pharmaceutical industry Labialfarma, (Laboratory of Pharmaceutical and Nutraceutical Products), more specifically at the Department of Research and Galenic Development, to which I belong. All the investigation, stability tests, and measurement of nanoparticles required for the development of this dissertation, were also performed at Labialfarma. Nanoemulsions that presented higher stability results, matched with the formulations with better organoleptic characteristics and smaller particle size.
Herbal and phytotherapeutical products are often used in dermatology, and, despite the reduced number of published studies, there is evidence for their use in psoriasis, acne, atopic dermatitis and other dermatological problems. In our days, some of these herbal products are highly required for this purpose, being often the only option to treat this disease. This dissertation focused on psoriasis, an inflammatory skin disease in which the erythemato-squamous lesions are characterized by a high cellular proliferation and by abnormal patterns of keratinocyte’s differentiation, in addition to biochemical, immunological and vascular abnormalities. Benefits of the use of medicinal plants in psoriasis, as well as their incorporation in nanocosmetics were assessed. The nanocosmetics industry provides active principles or other nanostructured ingredients to the formulations, and shows superior properties, in terms of performance, compared to conventional products. Nanoemulsion was the pharmaceutical form used due to the higher benefits to the present study. The oils of Calendula officinalis L. and Copaifera reticulata Duncke, and the essential oil of Matricaria recutita L. were used in the nanoemulsions as they hold great anti-inflammatory power, significant in the treatment of psoriasis. Throughout the work, various formulations of nanoemulsions (with different percentages of water and oil phase) were developed, in order to achieve stable nanoemulsions, with the desired organoleptic characteristics and particle size levels. The nanoemulsions were developed at the pharmaceutical industry Labialfarma, (Laboratory of Pharmaceutical and Nutraceutical Products), more specifically at the Department of Research and Galenic Development, to which I belong. All the investigation, stability tests, and measurement of nanoparticles required for the development of this dissertation, were also performed at Labialfarma. Nanoemulsions that presented higher stability results, matched with the formulations with better organoleptic characteristics and smaller particle size.
Description
Mestrado em cooperação com a Universidade de Salamanca