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The thienopyridine skeleton has been reported as having interesting biological activities namely antitumor[1,2] antiangiogenic.[3A] New fluorinated and methoxylated di(hetero)arylethers and di(hetero)arylamines were prepared functionalizing
7-position of the thieno[3,2-bJpyridine, using copper (C-O) or palladium (C-N) catalyzed couplings, respectively, of the 7-t>rolmo:
thieno[3,2-bJpyridine (1) with ortho, meta and para fluoro or methoxy phenols and anilines.
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Queiroz, Maria João R.P.; Peixoto, Daniela; Calhelha, Ricardo C.; Soares, Pedro; Santos, Tiago; Lima, Raquel T.; Campos, Joana F.; Abreu, Rui M.V.; Ferreira, Isabel C.F.R.; Vasconcelos, M. Helena (2014). New di(hetero)aryl)ethers and Di(hetero)arylamines in the thieno[3,2-b]pyridine series: synthesis, growth inhibitory activity on tumor cell lines and non tumor cells, effects on cell cycle and on apoptosis. In International Symposium of Medicinal Chemistry. Lisboa