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Temperature and solvent effects in the solubility of some drugs: experimental and modeling

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dc.contributor.authorQueimada, António
dc.contributor.authorMota, Fátima L.
dc.contributor.authorPinho, Simão
dc.contributor.authorMacedo, Eugénia A.
dc.date.accessioned2010-02-25T17:24:33Z
dc.date.available2010-02-25T17:24:33Z
dc.date.issued2009
dc.description.abstractNew drugs are always appearing during the development of new therapies or the improvement of existing ones. The effects of these drugs in the organism are dependent on the techniques used by the pharmaceutical industry to make them more soluble [1]. Solubility data involving new drug candidates are frequently not available in the open literature and, although predictive thermodynamic models can be used, the availability of experimental data is still fundamental for an appropriate model development and evaluation. One of the most recent and successful models is the Nonrandom Two Liquid Segment Activity Coefficient (NRTL-SAC) model [2-5], which gives reasonable results in the prediction of drug solubilities and has been widely applied to correlate and predict phase equilibria of highly nonideal systems, both in pure and mixed systems, both at academic and industrial level.pt
dc.identifier.citationQueimada, António; Mota, Fátima; Pinho, Simão; Macedo, Eugénia (2009). Temperature and solvent effects in the solubility of some drugs: experimental and modeling. In VIII Iberoamerican Conference on Phase Equilibria and Fluid Properties for Process Design. Portimão.pt
dc.identifier.urihttp://hdl.handle.net/10198/2180
dc.language.isoengpt
dc.subjectPharmaceutical compoundspt
dc.subjectSolubilitypt
dc.subjectMeasurementpt
dc.subjectNRTL-SACpt
dc.titleTemperature and solvent effects in the solubility of some drugs: experimental and modelingpt
dc.typeconference object
dspace.entity.typePublication
oaire.citation.conferencePlacePortimão, Portugalpt
oaire.citation.titleVIII EQUIFASE - Iberoamerican Conference on Phase Equilibria and Fluid Properties for Process Designpt
person.familyNamePinho
person.givenNameSimão
person.identifier810882
person.identifier.ciencia-id481D-73AD-8D0F
person.identifier.orcid0000-0002-9211-857X
person.identifier.ridD-4148-2013
person.identifier.scopus-author-id7003570175
rcaap.rightsopenAccesspt
rcaap.typeconferenceObjectpt
relation.isAuthorOfPublication8ef7789a-34f3-4915-a666-4efe26272a30
relation.isAuthorOfPublication.latestForDiscovery8ef7789a-34f3-4915-a666-4efe26272a30

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