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Advisor(s)
Abstract(s)
New drugs are always appearing during the development of new therapies or
the improvement of existing ones. The effects of these drugs in the organism
are dependent on the techniques used by the pharmaceutical industry to make
them more soluble [1]. Solubility data involving new drug candidates are
frequently not available in the open literature and, although predictive
thermodynamic models can be used, the availability of experimental data is still
fundamental for an appropriate model development and evaluation. One of the
most recent and successful models is the Nonrandom Two Liquid Segment
Activity Coefficient (NRTL-SAC) model [2-5], which gives reasonable results in
the prediction of drug solubilities and has been widely applied to correlate and
predict phase equilibria of highly nonideal systems, both in pure and mixed
systems, both at academic and industrial level.
Description
Keywords
Pharmaceutical compounds Solubility Measurement NRTL-SAC
Citation
Queimada, António; Mota, Fátima; Pinho, Simão; Macedo, Eugénia (2009). Temperature and solvent effects in the solubility of some drugs: experimental and modeling. In VIII Iberoamerican Conference on Phase Equilibria and Fluid Properties for Process Design. Portimão.