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Enhanced Antimalarial Activity of Extracts of Artemisia annua L. Achieved with Aqueous Solutions of Salicylate Salts and Ionic Liquids

2024Journal article Open access
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datacite.subject.fosEngenharia e Tecnologia::Engenharia Química
datacite.subject.sdg03:Saúde de Qualidade
datacite.subject.sdg09:Indústria, Inovação e Infraestruturas
datacite.subject.sdg12:Produção e Consumo Sustentáveis
datacite.subject.sdg13:Ação Climática
datacite.subject.sdg15:Proteger a Vida Terrestre
dc.contributor.authorFerreira, Ana M.
dc.contributor.authorSales, Isabela
dc.contributor.authorSantos, Sónia A.O.
dc.contributor.authorSantos, Tiago
dc.contributor.authorNogueira, Fátima
dc.contributor.authorMattedi, Silvana
dc.contributor.authorPinho, Simão
dc.contributor.authorCoutinho, João A.P.
dc.contributor.authorFreire, Mara G.
dc.date.accessioned2025-05-14T11:03:38Z
dc.date.available2025-05-14T11:03:38Z
dc.date.issued2024
dc.description.abstractArtemisinin, a drug used to treat malaria, can be chemically synthesized or extracted from Artemisia annua L. However, the extraction method for artemisinin from biomass needs to be more sustainable while maintaining or enhancing its bioactivity. This work investigates the use of aqueous solutions of salts and ionic liquids with hydrotropic properties as alternative solvents for artemisinin extraction from Artemisia annua L. Among the investigated solvents, aqueous solutions of cholinium salicylate and sodium salicylate were found to be the most promising. To optimize the extraction process, a response surface method was further applied, in which the extraction time, hydrotrope concentration, and temperature were optimized. The optimized conditions resulted in extraction yields of up to 6.50 and 6.44 mg·g-1, obtained with aqueous solutions of sodium salicylate and cholinium salicylate, respectively. The extracts obtained were tested for their antimalarial activity, showing a higher efficacy against the Plasmodium falciparum strain compared with pure (synthetic) artemisinin or extracts obtained with conventional organic solvents. Characterization of the extracts revealed the presence of artemisinin together with other compounds, such as artemitin, chrysosplenol D, arteannuin B, and arteannuin J. These compounds act synergistically with artemisinin and enhance the antimalarial activity of the obtained extracts. Given the growing concern about artemisinin resistance, the results here obtained pave the way for the development of sustainable and biobased antimalarial drugs. © 2024 The Authors. Co-published by Zhejiang University and American Chemical Society.eng
dc.description.sponsorshipThis work was developed partly within the scope of the project CICECO, UIDB/50011/2020, UIDP/50011/2020, and LA/P/0006/2020, financed by national funds through the FCT/MCTES (PIDDAC). The authors are grateful to the FCT for the financial support through national funds FCT/MCTES (PIDDAC) to CIMO (UIDB/00690/2020 and UIDP/00690/2020), SusTEC (LA/P/0007/2021), GHTM UID/04413/2020 and LA-REAL-LA/P/0117/2020, PTDC/BTMSAL/29786/2017, and GreenHealth (Norte-01-0145-FEDER-000042). A.M.F. and S.A.O.S. also acknowledge FCT for the research contracts CEECIND/00361/2022 and CEECIND/03348/2021 under the Scientific Stimulus − Individual Call, respectively. I.S. and S.M. thanks the financial support from CAPES and CNPq/Brazil (CAPES: Proc. 88881.189075/2018-01 and 88887.494428/2020-00. CNPq: Grant 311342/2022-1 and Proc. 438036/2018-2).
dc.identifier.citationFerreira, Ana M.; Sales, Isabela; Santos, Sónia A. O.; Santos, Tiago; Nogueira, Fátima; Mattedi, Silvana; Pinho, Simão; Coutinho, João A. P.; Freire, Mara G. (2024). Enhanced Antimalarial Activity of Extracts of Artemisia annua L. Achieved with Aqueous Solutions of Salicylate Salts and Ionic Liquids. Chem and Bio Engineering. eISSN 2836-967X. 1:1, p. 44–52
dc.identifier.doi10.1021/cbe.3c00005
dc.identifier.eissn2836-967X
dc.identifier.urihttp://hdl.handle.net/10198/34473
dc.language.isoeng
dc.peerreviewedyes
dc.publisherAmerican Chemical Society
dc.relationCICECO-Aveiro Institute of Materials
dc.relationCICECO-Aveiro Institute of Materials
dc.relationMountain Research Center
dc.relationMountain Research Center
dc.relationCICECO – Aveiro Institute of Materials
dc.relationUID/04413/2020
dc.relation.ispartofChem & Bio Engineering
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectArtemisia annua L
dc.subjectHydrotropes
dc.subjectIonic liquids/salts
dc.subjectMalaria
dc.subjectNatural extract
dc.subjectPlasmodium falciparum
dc.subjectAntimalarial activity
dc.subjectSodium salicylate
dc.subjectArtemisinin
dc.titleEnhanced Antimalarial Activity of Extracts of Artemisia annua L. Achieved with Aqueous Solutions of Salicylate Salts and Ionic Liquidseng
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleCICECO-Aveiro Institute of Materials
oaire.awardTitleCICECO-Aveiro Institute of Materials
oaire.awardTitleMountain Research Center
oaire.awardTitleMountain Research Center
oaire.awardTitleCICECO – Aveiro Institute of Materials
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F50011%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F50011%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00690%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F00690%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0006%2F2020/PT
oaire.citation.endPage52
oaire.citation.issue1
oaire.citation.startPage44
oaire.citation.titleChem & Bio Engineering
oaire.citation.volume1
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
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project.funder.identifierhttp://doi.org/10.13039/501100001871
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project.funder.nameFundação para a Ciência e a Tecnologia
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project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
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