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Comprehensive characterization and development of multi-core shell superparamagnetic nanoparticles for controlled delivery of drugs and their kinetic release modelling

2023Journal article Open access
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dc.contributor.authorMoretto, Simone
dc.contributor.authorSilva, Adriano S.
dc.contributor.authorDíaz de Tuesta, Jose Luis
dc.contributor.authorRoman, Fernanda
dc.contributor.authorCortesi, Rita
dc.contributor.authorBertão, Ana Raquel
dc.contributor.authorBañobre-López, Manuel
dc.contributor.authorPedrosa, Marta
dc.contributor.authorSilva, Adrián
dc.contributor.authorGomes, Helder
dc.date.accessioned2023-12-18T10:25:25Z
dc.date.available2023-12-18T10:25:25Z
dc.date.issued2023
dc.description.abstractThe nanoparticles designed for application in cancer treatment should have biocompatibility, colloidal stability and triggered release at tumor sites. Magnetic nanoparticles arise as an interesting option to be used as drug nanocarriers, considering the possibility of driving nanoparticles to the correct delivery site and exploring different triggers to achieve such accomplishment. In this study, nickel ferrite nanoparticles are explored as a magnetic core for drug delivery systems, using doxorubicin and omeprazole as model drugs. The developed nickel ferrite presents a strong superparamagnetic behavior and high purity, as demonstrated by magnetometry and TGA results. The carbon-coating procedure and functionalization allowed the nanoparticle to achieve the desired characteristics for biomedical applications (i.e. stability in water, biocompatibility, and size). According to TEM results, the final carbon-coated magnetic nanoparticles have an average size of 25.09 ± 0.58 nm and multi-core shell architecture, which is suitable for biomedical applications as drug nanocarriers. In addition, DLS demonstrated that functionalized nanoparticles are monodisperse, with a hydrodynamic diameter of 167 ± 59 nm, which fits the recommended range (100–200 nm) to benefit from enhanced permeability and retention effect. Drug loading tests with doxorubicin and omeprazole revealed the versatility of the designed nanoparticles, able to load 97% of doxorubicin and 51% of omeprazole. The pH-triggered release was also confirmed for both pharmacological compounds, showing a higher cumulative drug under acidic conditions (simulating a tumor microenvironment). Finally, the kinetic analysis applied to the study of the release mechanism of both medicines showed that non-linear models fit with higher accuracy the experimental data.pt_PT
dc.description.sponsorshipThis work is a result of Project “RTChip4Theranostics – Real time Liver-on-a-chip platform with integrated micro(bio)sensors for preclinical validation of graphene-based magnetic nanocarriers towards cancer theranostics”, with the reference NORTE-01-0145-FEDER-029394, supported by Norte Portugal Regional Operational Programme (NORTE 2020), under the Portugal 2020 Partnership Agreement, through the European Regional Development Fund (ERDF); and CIMO (UIDB/00690/2020) through FEDER under Program PT2020. Financial support was also obtained from LA/P/0045/2020 (AliCE), UIDB/ 50020/2020 and UIDP/50020/2020 (LSRE-LCM), funded by national funds through FCT/MCTES (PIDDAC). Adriano S. Silva thanks his doctoral Grant with reference SFRH/BD/151346/2021 financed by the Portuguese Foundation for Science and Technology (FCT), with funds from NORTE2020, under the MIT Portugal Program. Fernanda F. Roman acknowledges FCT and FSE for the individual research grant (SFRH/BD/ 143224/2019). Jose L. Diaz De Tuesta acknowledges the financial support through the program of Atracción al Talento of Comunidad de Madrid (Spain) for the individual research grant 2022-T1/AMB-23946. Marta Pedrosa acknowledges FCT funding under the 5th Edition Call for Scientific Employment Stimulus – Individual Contract (2022.00192. CEECIND).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMoretto, Simone; Silva, Adriano S.; Díaz de Tuesta, Jose Luis; Roman, Fernanda; Cortesi, Rita; Bertão, Ana Raquel; Bañobre-López, Manuel; Pedrosa, Marta; Silva, Adrián; Gomes, Helder (2023). Comprehensive characterization and development of multi-core shell superparamagnetic nanoparticles for controlled delivery of drugs and their kinetic release modelling. Materials Today Chemistry. eISSN 2468-5194. 33, p. 1-14pt_PT
dc.identifier.doi10.1016/j.mtchem.2023.101748pt_PT
dc.identifier.eissn2468-5194
dc.identifier.urihttp://hdl.handle.net/10198/28966
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationMountain Research Center
dc.relationALICE - Associate Laboratory in Chemical Engineering
dc.relationLaboratory of Separation and Reaction Engineering - Laboratory of Catalysis and Materials
dc.relationLaboratory of Separation and Reaction Engineering - Laboratory of Catalysis and Materials
dc.relationAmphiphilic carbon-based materials for one-pot desulfurization and denitrogenation of liquid fuels
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectDrug delivery systempt_PT
dc.subjectDoxorubicinpt_PT
dc.subjectOmeprazolept_PT
dc.subjectMagnetic nanoparticlespt_PT
dc.subjectNickel ferritept_PT
dc.subjectCancerpt_PT
dc.titleComprehensive characterization and development of multi-core shell superparamagnetic nanoparticles for controlled delivery of drugs and their kinetic release modellingpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleMountain Research Center
oaire.awardTitleALICE - Associate Laboratory in Chemical Engineering
oaire.awardTitleLaboratory of Separation and Reaction Engineering - Laboratory of Catalysis and Materials
oaire.awardTitleLaboratory of Separation and Reaction Engineering - Laboratory of Catalysis and Materials
oaire.awardTitleAmphiphilic carbon-based materials for one-pot desulfurization and denitrogenation of liquid fuels
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00690%2F2020/PT
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oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POR_NORTE/SFRH%2FBD%2F151346%2F2021/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POR_NORTE/SFRH%2FBD%2F143224%2F2019/PT
oaire.citation.endPage14pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleMaterials Today Chemistrypt_PT
oaire.citation.volume33pt_PT
oaire.fundingStream6817 - DCRRNI ID
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oaire.fundingStream6817 - DCRRNI ID
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person.familyNameSilva
person.familyNameDíaz de Tuesta
person.familyNameRoman
person.familyNameGomes
person.givenNameAdriano S.
person.givenNameJose Luis
person.givenNameFernanda
person.givenNameHelder
person.identifier.ciencia-id3E14-5049-B09D
person.identifier.ciencia-id7A1F-022B-7DBF
person.identifier.ciencia-idEE1B-DAA7-D0BD
person.identifier.ciencia-id6218-1E19-13EE
person.identifier.orcid0000-0002-6795-2335
person.identifier.orcid0000-0003-2408-087X
person.identifier.orcid0000-0001-5360-5298
person.identifier.orcid0000-0001-6898-2408
person.identifier.ridD-9785-2017
person.identifier.scopus-author-id55755821600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
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project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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