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Potential wound healing effect of gel based on chicha gum, chitosan, and mauritia flexuosa oil

2022Journal article Open access
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dc.contributor.authorFerreira, Maria Onaira Gonçalves
dc.contributor.authorRibeiro, Alessandra Braga
dc.contributor.authorRizzo, Marcia Santos
dc.contributor.authorOliveira, Antonia Carla de Jesus
dc.contributor.authorOsajima, Josy Anteveli
dc.contributor.authorEstevinho, Leticia M.
dc.contributor.authorSilva-Filho, Edson C.
dc.date.accessioned2022-05-19T14:38:44Z
dc.date.available2022-05-19T14:38:44Z
dc.date.issued2022
dc.description.abstractWounds are considered a clinically critical issue, and effective treatment will decrease complications, prevent chronic wound formation, and allow rapid healing. The development of products based on naturally occurring materials is an efficient approach to wound healing. Natural polysaccharides can mimic the extracellular matrix and promote cell growth, thus making them attractive for wound healing. In this context, the aim of this work was to produce a gel based on chicha gum, chitosan, and Mauritia flexuosa oil (CGCHO) for wound treatment. TG and DTG analyzed the thermal behavior of the materials, and SEM investigated the surface roughness. The percentages of total phenolic compounds, flavonoids, and antioxidants were determined, presenting a value of 81.811 7.257 mol gallic acid/g Mauritia flexuosa oil, 57.915 0.305 mol quercetin/g Mauritia flexuosa oil, and 0.379 mg/mL, respectively. The anti-inflammatory was determined, presenting a value of 10.35 1.46% chicha gum, 16.86 1.00% Mauritia flexuosa oil, 10.17 1.05% CGCHO, and 15.53 0.65% chitosan, respectively. The materials were tested against Gram-negative (Klebsiella pneumoniae) and Gram-positive (Staphylococcus aureus) bacteria and a fungus (Candida albicans). The CGCHO formulation showed better antimicrobial activity against Grampositive bacteria. In addition, an in vivo wound healing study was also performed. After 21 days of treatment, the epidermal re-epithelialization process was observed. CGCHO showed good thermal stability and roughness that can help in cell growth and promote the tissue healing process. In addition to the good results observed for the antimicrobial, antioxidant, anti-inflammatory activities and providing wound healing, they provided the necessary support for the healing process, thus representing a new approach to the wound healing process.pt_PT
dc.description.sponsorshipThe authors acknowledge the Coordination for the Improvement of Higher Education Personnel, the Brazilian Ministry of Education, financial support for the scholarship. To National Council for Scientific and Technological Development (CNPq), and Piaui State Research Support Foundation (FAPEPI). The authors are thankful to CNPq for financial support (Postdoctoral fellow 164646/2020-5), and NORTE-01-0247-FEDER-113540-“Pharmapitox-Desenvolvimento de um coletor inovador e protocolo para purificação da apitoxina para uso nas indústrias farmacêutica e cosmética”.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationFerreira, Maria Onaira Gonçalves; Ribeiro, Alessandra Braga; Rizzo, Marcia S.; Oliveira, Antonia Carla de Jesus; Osajima, Josy Anteveli; Estevinho, Leticia M.; Silva-Filho, Edson C. (2022). Potential wound healing effect of gel based on chicha gum, chitosan, and mauritia flexuosa oil. Biomedicines. EISSN 2227-9059. 10:4, p. 1-14pt_PT
dc.identifier.doi10.3390/biomedicines10040899pt_PT
dc.identifier.eissn2227-9059
dc.identifier.urihttp://hdl.handle.net/10198/25489
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectPolysaccharidespt_PT
dc.subjectChicha gumpt_PT
dc.subjectChitosanpt_PT
dc.subjectMauritia flexuosa oilpt_PT
dc.subjectAntimicrobial activitypt_PT
dc.subjectWound healingpt_PT
dc.titlePotential wound healing effect of gel based on chicha gum, chitosan, and mauritia flexuosa oilpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue4pt_PT
oaire.citation.startPage899pt_PT
oaire.citation.titleBiomedicinespt_PT
oaire.citation.volume10pt_PT
person.familyNameEstevinho
person.givenNameLetícia M.
person.identifier.ciencia-idBA14-09D6-A406
person.identifier.orcid0000-0002-9249-1948
person.identifier.scopus-author-id6506577664
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication4a1d5ba2-1854-4ca5-89a4-73f35e964df9
relation.isAuthorOfPublication.latestForDiscovery4a1d5ba2-1854-4ca5-89a4-73f35e964df9

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