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Advances in Microfluidic Systems and Numerical Modeling in Biomedical Applications: A Review

2024Journal article Open access
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dc.contributor.authorFerreira, Mariana
dc.contributor.authorCarvalho, Violeta Meneses
dc.contributor.authorRibeiro, J.E.
dc.contributor.authorLima, Rui A.
dc.contributor.authorTeixeira, Senhorinha F.C.F.
dc.contributor.authorPinho, Diana
dc.date.accessioned2024-10-08T11:27:39Z
dc.date.available2024-10-08T11:27:39Z
dc.date.issued2024
dc.description.abstractThe evolution in the biomedical engineering field boosts innovative technologies, with microfluidic systems standing out as transformative tools in disease diagnosis, treatment, and monitoring. Numerical simulation has emerged as a tool of increasing importance for better understanding and predicting fluid-flow behavior in microscale devices. This review explores fabrication techniques and common materials of microfluidic devices, focusing on soft lithography and additive manufacturing. Microfluidic systems applications, including nucleic acid amplification and protein synthesis, as well as point-of-care diagnostics, DNA analysis, cell cultures, and organ-on-a-chip models (e.g., lung-, brain-, liver-, and tumor-on-a-chip), are discussed. Recent studies have applied computational tools such as ANSYS Fluent 2024 software to numerically simulate the flow behavior. Outside of the study cases, this work reports fundamental aspects of microfluidic simulations, including fluid flow, mass transport, mixing, and diffusion, and highlights the emergent field of organ-on-a-chip simulations. Additionally, it takes into account the application of geometries to improve the mixing of samples, as well as surface wettability modification. In conclusion, the present review summarizes the most relevant contributions of microfluidic systems and their numerical modeling to biomedical engineering.pt_PT
dc.description.sponsorshipThis research was funded by the following projects: 2022.02085.PTDC (https://doi. org/10.54499/2022.02085.PTDC), 2022.06207.PTDC (https://doi.org/10.54499/2022.06207.PTDC), PTDC/EEI-EEE/2846/2021 (https://doi.org/10.54499/PTDC/EEI-EEE/2846/2021), and through national funds (OE), within the scope of the Scientific Research and Technological Development Projects (IC&DT) program in all scientific domains (PTDC), through the FCT, I.P. The authors also acknowledge the partial financial support within the R&D Units Project Scope UIDB/04436/2020, UIDP/04436/2020, UIDB/04077/2020, UIDP/04077/2020, UIDB/00532/2020, UIDB/00690/2020, UIDB/04650/2020, and LA/P/0045/2020 (ALiCE). Diana Pinho also gives thanks to the FCT for the individual funding, 2021.00027.CEECIND/CP1664/CT0007 (https://doi.org/10.54499/2021.00027. CEECIND/CP1664/CT0007). Violeta Carvalho gives thanks for her Ph.D. grant from the FCT with reference UI/BD/151028/2021.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationFerreira, Mariana; Carvalho, Violeta; Ribeiro, João; Lima, Rui A.; Teixeira, Senhorinha; Pinho, Diana (2024). Advances in Microfluidic Systems and Numerical Modeling in Biomedical Applications: A Review. Micromachines. ISSN 2072-666X. 15:7, p. 1-30pt_PT
dc.identifier.doi10.3390/mi15070873pt_PT
dc.identifier.issn2072-666X
dc.identifier.urihttp://hdl.handle.net/10198/30368
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationPortable Microfluidic system for fast molecular diagnostics of Stroke
dc.relationMultiplexed micro(bio)sensors array integrated into an organ-on-a-chip device for assessing cancer NANOtherapy
dc.relationMicroelectromechanical Systems Research Unit
dc.relationMicroelectromechanical Systems Research Unit
dc.relationMechanical Engineering and Resource Sustainability Center
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dc.relationTransport Phenomena Research Center
dc.relationMountain Research Center
dc.relationPhysics Center of Minho and Porto Universities
dc.relationALICE - Associate Laboratory in Chemical Engineering
dc.relationNEXTGENmOCp: Next generation of a microfluidic Organ-on-a-Chip platform (mOCp) to assess and diagnosis therapeutic effects of innovative nanomedicines
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectNumerical simulationpt_PT
dc.subjectMicrofluidicspt_PT
dc.subjectOrgan-on-a-chippt_PT
dc.subjectMicrofluidics systemspt_PT
dc.subjectMixingpt_PT
dc.titleAdvances in Microfluidic Systems and Numerical Modeling in Biomedical Applications: A Reviewpt_PT
dc.typejournal article
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oaire.awardTitleMultiplexed micro(bio)sensors array integrated into an organ-on-a-chip device for assessing cancer NANOtherapy
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oaire.citation.issue7pt_PT
oaire.citation.startPage873pt_PT
oaire.citation.titleMicromachinespt_PT
oaire.citation.volume15pt_PT
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